1989
DOI: 10.1161/01.cir.80.4.1070
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The cholesterol controversy is over. Why did it take so long?

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Cited by 102 publications
(33 citation statements)
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“…Only after the NIH-sponsored landmark Coronary Primary Prevention Trial, showing that CHD risk was indeed reduced by lowering blood cholesterol levels (18), and the subsequent 1984 NIH Consensus Conference on Lowering Blood Cholesterol (19) did correction of hypercholesterolemia become a serious therapeutic goal here and abroad. There were multiple reasons for the delay (20), but my thesis here is that the case was already clear enough by 1970 to justify a call for preventive programs.…”
mentioning
confidence: 93%
“…Only after the NIH-sponsored landmark Coronary Primary Prevention Trial, showing that CHD risk was indeed reduced by lowering blood cholesterol levels (18), and the subsequent 1984 NIH Consensus Conference on Lowering Blood Cholesterol (19) did correction of hypercholesterolemia become a serious therapeutic goal here and abroad. There were multiple reasons for the delay (20), but my thesis here is that the case was already clear enough by 1970 to justify a call for preventive programs.…”
mentioning
confidence: 93%
“…The precise regulation of cholesterol metabolism is essential, and it is well known that elevated levels of cholesterol in the blood are a major cause of cardiovascular disease (1). Studies using global genetic knockouts and synthetic agonists have defined important roles for the liver X receptors LXRα (NR1H3) and LXRβ (NR1H2) in the control of cholesterol metabolism (2).…”
Section: Introductionmentioning
confidence: 99%
“…Elevated plasma LDL-cholesterol is a recognised risk factor for cardiovascular disease 19 and atherosclerosis is reported to increase coronary vasoconstric- tion in man. 20 Several previous studies in animals have reported that experimental hypercholesterolaemia and atherosclerosis increase vascular reactivity.…”
Section: Discussionmentioning
confidence: 99%