The choroid plexus synergizes with immune cells during neuroinflammation

Xu, Huixin; Lotfy, Peter; Gelb, Sivan; Pragana, Aja; Hehnly, Christine; Byer, Lillian I.J.; Shipley, Frederick B.; Zawadzki, Miriam E.; Cui, Jin; Deng, Liwen; Taylor, Milo; Webb, Mya; Lidov, Hart G.W.; Andermann, Mark L.; Chiu, Isaac M.; Ordovas-Montanes, Jose; Lehtinen, Maria K.

doi:10.1016/j.cell.2024.07.002

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Cited by 10 publications

References 94 publications

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A microglia-containing cerebral organoid model to study early life immune challenges

Buonfiglioli,

Kübler,

Missall

et al. 2025

Brain, Behavior, and Immunity

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A microglia-containing cerebral organoid model to study early life immune challenges

Buonfiglioli,

Kübler,

Missall

et al. 2025

Brain, Behavior, and Immunity

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Beyond borders: the choroid plexus-immune communication during neuroinflammation

Dumas,

Dalmau Gasull,

Prinz

2024

Sig Transduct Target Ther

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A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

Qiao,

Qu,

Qiu

et al. 2024

Preprint

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The coronavirus disease of 2019 (COVID-19), caused by the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), remains a major health issue after nearly 7 millions of death toll in the last four years. As the world is recovering with improving vaccines and antiviral treatments, the alarming rate of long-COVID, or Post-acute Sequelae of COVID-19 (PASC), calls for further investigations. Among a list of symptoms associated with multi-organ dysfunctions, the neurological complications are particularly intriguing, yet the underlying mechanisms remain elusive. With the recently developed mouse adapted SARS-CoV-2 stain, we are now able to model the mild COVID infection in C57BL/6 mice and study the chronic immune responses and subsequent damages in different organs long after the viruses are clearly naturally in the body. More specifically, we found adult C57BL/6J mice developed neurological impairments, including behavior changes related to sensorimotor coordination, depression- and anxiety-like behaviors, and inflammation in multiple organs including lung, liver and brain, which persisted over at least 4 weeks in mice even with mild infection. Therefore, this model can be used to further explopred the mechanisms of PASC, as well as potential intervention or therapeutic approaches.

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The choroid plexus synergizes with immune cells during neuroinflammation

Cited by 10 publications

References 94 publications

A microglia-containing cerebral organoid model to study early life immune challenges

A microglia-containing cerebral organoid model to study early life immune challenges

Beyond borders: the choroid plexus-immune communication during neuroinflammation

A Mouse-adapted SARS-CoV-2 Model for Investigating Post-acute Sequelae of COVID infection

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