2012
DOI: 10.1681/asn.2011080842
|View full text |Cite
|
Sign up to set email alerts
|

The Circadian Clock Modulates Renal Sodium Handling

Abstract: The circadian clock contributes to the control of BP, but the underlying mechanisms remain unclear. We analyzed circadian rhythms in kidneys of wild-type mice and mice lacking the circadian transcriptional activator clock gene. Mice deficient in clock exhibited dramatic changes in the circadian rhythm of renal sodium excretion. In parallel, these mice lost the normal circadian rhythm of plasma aldosterone levels. Analysis of renal circadian transcriptomes demonstrated changes in multiple mechanisms involved in… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

4
123
0
1

Year Published

2013
2013
2023
2023

Publication Types

Select...
6
3

Relationship

1
8

Authors

Journals

citations
Cited by 127 publications
(128 citation statements)
references
References 30 publications
4
123
0
1
Order By: Relevance
“…We (16,18,31,36) have previously shown that Per1 regulates both the basal and aldosterone-mediated regulation of the ␣-subunit of the renal epithelial Na ϩ channel (␣-ENaC). We (26) have also demonstrated that Per1 coordinately regulates the expression of multiple genes that contribute to the regulation of renal Na ϩ reabsorption. These include Per1-mediated positive regulation of Fxyd5, a positive regulator of Na ϩ -K ϩ -ATPase (22), and negative regulation of endothelin (ET)-1, a potent inhibitor of ENaC (9,23).…”
mentioning
confidence: 78%
See 1 more Smart Citation
“…We (16,18,31,36) have previously shown that Per1 regulates both the basal and aldosterone-mediated regulation of the ␣-subunit of the renal epithelial Na ϩ channel (␣-ENaC). We (26) have also demonstrated that Per1 coordinately regulates the expression of multiple genes that contribute to the regulation of renal Na ϩ reabsorption. These include Per1-mediated positive regulation of Fxyd5, a positive regulator of Na ϩ -K ϩ -ATPase (22), and negative regulation of endothelin (ET)-1, a potent inhibitor of ENaC (9,23).…”
mentioning
confidence: 78%
“…Clock knockout (KO) mice are relatively hypotensive and exhibit dysregulated urinary Na ϩ excretion and mild diabetes insipidus (26,40). Per2 KO mice exhibit decreased 24-h diastolic BP, increased heart rate, and reduced daytime dipping (18).…”
mentioning
confidence: 99%
“…Urine collection was performed after a 3-day adaptation period. Urine osmolality, pH, and ionic composition were analyzed as previously described (22).…”
Section: Animalsmentioning
confidence: 99%
“…Urinary K ϩ excretion is known to follow circadian variations, with increased excretion during the period of activity independently of nutritional behavior (61,62). These circadian variations persist in dark-dark condition and are partially abolished in clock-null mice, indicating that they depend on the internal clock system (63). This ability to anticipate the periods of high and low food intake, respectively, during periods of activity and rest and to adapt the level of excretion accordingly enables the organism to maintain a stable level of plasma K ϩ (71).…”
Section: Relevance Of Hka2 In Renal Physiologymentioning
confidence: 99%