The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review

Xie, Yimin; Yuan, Xuefeng; Zhou, Weimin; Kosiba, Anthony Adebayiga; Shi, Haifeng; Gu, Jie; Qin, Zhenqian

doi:10.1016/j.lfs.2019.117252

Cited by 54 publications

(47 citation statements)

References 65 publications

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“…circHIPK3 (hsa_circ 0000284) is a circular RNA derived from the second exon of the HIPK3 gene. circHIPK3 is highly expressed in liver, brain, and lung (13)(14)(15) and has shown an important role in the regulation of cell survival, oxidative damage, and inflammation (16)(17)(18). We note that circHIPK3 is also expressed in pancreatic tissue (19).…”

Section: Introductionmentioning

confidence: 77%

CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis

Wang

Liu

et al. 2020

Front. Med.

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Acute pancreatitis (AP), especially severe acute pancreatitis (SAP), is an extremely dangerous illness with a high mortality rate. Pyroptotic cells release their cellular contents and inflammatory factors, aggravating the inflammatory response. Pyroptosis may be the main mode of acinar cell death during AP. The circular RNA circHIPK3 is expressed in pancreatic tissue and is associated with inflammatory response. In this study, we focused on the role and underlying mechanism of circHIPK3 in AP. We found that the expression of circHIPK3 was significantly elevated in serum of patients with AP and in caerulein-stimulated AR42J cells and was associated with caspase-1 and caspase-11 activation. circHIPK3 silencing ameliorated caerulein-induced cell damage and reduced the release of inflammatory factors IL-1β, IL-6, IL-8, and TNF-α and inhibited the activation of caspase-1 and caspase-11. In addition, circHIPK3 bound to miR-193a-5p and negatively regulated its expression. Inhibition of miR-193a-5p increased the release of IL-1β, IL-6, IL-8, and TNF-α and activated caspase-1 and caspase-11, thereby counteracting the effect of circHIPK3 silencing on caerulein-induced cell damage. Furthermore, we identified GSDMD as a target gene of miR-193a-5p, which is the key gene for pyroptosis. Interfering with the expression of GSDMD can increase cell viability, reduce the secretion of inflammatory cytokines, and suppress the activation of cleaved caspase-1 and caspase-11. Silencing GSDMD reversed the effects of miR-193a-5p inhibitors on caerulein-induced damage. In conclusion, circHIPK3 promotes pyroptosis in acinar cells through regulation of the miR-193a-5p/GSDMD axis, which eventually aggravates AP disease.

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Section: Introductionmentioning

confidence: 77%

CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis

Wang

Liu

et al. 2020

Front. Med.

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“…It was found that circHIPK3 contained more than one binding site of multiple miRNAs, which could inhibit the activity of miRNA [24]. Previous reports have shown cir-cHIPK3 is abundant in multiple cancers and can enhance the growth of cancer cells [25][26][27]. For example, in oral squamous cell carcinoma, downregulation of the circHIPK3 gene can reduce the adsorption of miR-124, which can normally regulate the downstream target gene and suppress cancer cell growth [28].…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Circular RNA circHIPK3 Promotes Cell Metastasis through miR‐637/STAT3 Axis in Osteosarcoma

Huang

Yuan

et al. 2020

BioMed Research International

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Recent studies have suggested that circular RNAs play an important role in the progression of various cancers. However, few studies have revealed the great value of circRNAs in the diagnosis and prognosis prediction of osteosarcoma (OS). In this study, we performed experiments with the human OS cell lines and the results showed that the expression of circHIPK3 in OS cell lines was significantly upregulated compared to that in the normal cell line. In addition, the results showed that circHIPK3 could promote the migration, invasion, and growth of OS cells. Furthermore, miR-637 was identified as a target of circHIPK3, while STAT3 was targeted by miR-637. circHIPK3 could promote STAT3 expression via interacting with miR-637 in OS cells. In conclusion, our research uncovered an important role of the circHIPK3/miR-637/STAT3 pathway in the migration and invasion of OS cells and suggested that circHIPK3 may be a prognostic marker and a promising therapeutic target for OS.

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“…Liu et al (2018) found a general decrease in the expression of circHIPK3 in all three subtypes of ARC (cortical, nuclear, and posterior subcapsular ARC). CircHIPK3 is an abundant and highly conserved circRNA that is involved in a series of physiological or pathological activities (Xie et al, 2020). Silencing circHIPK3 led to the suppression of various cell activities in primary cultured HLECs, such as cell viability, proliferation, EMT, and anti-apoptosis under oxidative stress (Liu et al, 2018).…”

Section: Age-related Cataractmentioning

confidence: 99%

CircRNA Is a Rising Star in Researches of Ocular Diseases

Zhang

2020

Front. Cell Dev. Biol.

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A newly rediscovered subclass of noncoding RNAs, circular RNAs (circRNAs), is produced by a back-splicing mechanism with a covalently closed loop structure. They not only serve as the sponge for microRNAs (miRNAs) and proteins but also regulate gene expression and epigenetic modification, translate into peptides, and generate pseudogenes. Dysregulation of circRNA expression has opened a new chapter in the etiology of various human disorders, including cancer and cardiovascular, neurodegenerative, and ocular diseases. Recent studies recognized the vital roles that circRNAs played in the pathogenesis of various eye diseases, highlighting circRNAs as promising biomarkers for diagnosis and assessment of progression and prognosis. Interventions targeting circRNAs provide insights for developing novel treatments for these ocular diseases. This review summarizes our current perception of the properties, biogenesis, and functions of circRNAs and the development of circRNA researches related to ophthalmologic diseases, including diabetic retinopathy, age-related macular degeneration, retinopathy of prematurity, glaucoma, corneal neovascularization, cataract, pterygium, proliferative vitreoretinopathy, retinoblastoma, and ocular melanoma.

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The circular RNA HIPK3 (circHIPK3) and its regulation in cancer progression: Review

Cited by 54 publications

References 65 publications

CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis

CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis

[Retracted] Circular RNA circHIPK3 Promotes Cell Metastasis through miR‐637/STAT3 Axis in Osteosarcoma

CircRNA Is a Rising Star in Researches of Ocular Diseases

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