The clinic factors in evaluating long-term outcomes of patients with stage I colorectal cancer

Jin, Zechuan; Wu, Qingbin; Deng, Xiangbing; Wang, Ziqiang

doi:10.1016/j.asjsur.2021.11.055

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…For example, preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII) all have predictive value for CRC, and preoperative SII has better predictive ability than NLR and PLR ( 10 ). However, previous studies often consider CRC as a whole entity and rarely investigate the separate effects of preoperative SII on the prognosis of rectal cancer ( 11 , 12 ). Given their distinct locations and varying prognoses, studying colon and rectal cancer separately may reduce prognostic differences associated with different tumor sites.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of preoperative combined with postoperative systemic immune-inflammation index for disease-free survival after radical rectal cancer surgery: a retrospective cohort study

Sun,

Yang,

et al. 2024

Transl Cancer Res

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Background Colorectal cancer (CRC) ranks highly in malignant tumor incidence and mortality rates, severely affecting human health. The predictive value of the systemic immune-inflammation index (SII) in CRC prognosis is gaining attention, but there is limited research on the combined preoperative and postoperative SII. This study aims to explore the prognostic value of combined SII on disease-free survival (DFS) in patients undergoing radical surgery for rectal cancer. Methods We enrolled 292 patients with rectal cancer who underwent radical resection at the Affiliated Hospital of Xuzhou Medical University from May 2018 to September 2020, along with regular follow-ups to document the DFS. Patients’ complete blood cell counts were assessed before surgery and between 21–56 days postoperatively. Calculating preoperative and postoperative SII, patients were categorized into four groups based on the optimal cutoff values: (I) low-low group (preoperative SII <449.325 and postoperative SII <568.13); (II) high-low group (preoperative SII ≥449.325 and postoperative SII <568.13); (III) low-high group (preoperative SII <449.325 and postoperative SII ≥568.13); and (IV) high-high group (preoperative SII ≥449.325 and postoperative SII ≥568.13). The receiver operating characteristic (ROC) curve analysis evaluated the prediction efficacy of preoperative, postoperative, and combined SII. Kaplan-Meier analysis generated DFS curves, and Cox regression analysis determined prognostic factors. Results With a median follow-up of 41 months, 65.4% (191/292) patients reached DFS. The clinical pathological features between the four groups are balanced and comparable (P>0.05). The area under the ROC curve for preoperative, postoperative, and combined SII was 0.668 [95% confidence interval (CI): 0.6–0.737], 0.696 (95%CI: 0.63–0.763), and 0.741 (95% CI: 0.681–0.802), respectively. After adjusting for confounding factors such as adjuvant therapy, differentiation, vascular invasion, neural invasion, tumor-node-metastasis (TNM) stage, carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9), significant differences were observed between the high-low group [hazard ratio (HR) =2.403; 95% CI: 1.255–4.602; P=0.008], low-high group (HR =5.058; 95% CI: 2.389–10.71; P<0.001), and high-high group (HR =6.214; 95% CI: 3.474–11.115; P<0.001) compared to the low-low group, with higher risks of adverse outcomes. Conclusions Combined SII has better predictive efficacy than monitoring preoperative or postoperative SII alone in rectal cancer patients undergoing radical surgery.

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Section: Introductionmentioning

confidence: 99%

Prognostic value of preoperative combined with postoperative systemic immune-inflammation index for disease-free survival after radical rectal cancer surgery: a retrospective cohort study

Sun,

Yang,

et al. 2024

Transl Cancer Res

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Post recurrence survival in early versus late period and its prognostic factors in rectal cancer patients

Shahabi,

Mehri,

Abdollahi

et al. 2024

Sci Rep

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To identify factors associated with post-recurrence survival (PRS), we examined our institutional recurrence patterns following definitive resection for rectal cancer. We reviewed all patients with rectal cancer diagnosed at three hospitals in the east of Iran from 2011 to 2020. The optimal cut-off value was determined by receiver operating characteristic (ROC) analysis to determine early recurrence. The effect of recurrence time was evaluated on PRS. 326 eligible patients with a mean ± SD age of 56 ± 12.8 years were included in this study. In a median (IQR: Inter-quartile range) follow-up time of 76 (62.2) months, 106 (32.5%) patients experienced at least any recurrence (locoregional or distant metastasis) following primary resection. The median (IQR) time from initial surgery to recurrence was 29.5 (31.2) months. Based on ROC analysis, early recurrence was specified at ≤ 29 months. However, for the patients who experienced only locoregional recurrence, 33 months was the cut-off to define early recurrence. Recurrence time and recurrence management were both significant variables on PRS. Moreover, TNM staging was significantly associated with early recurrence ( P = 0.003). In this research, recurrence time, recurrence management and TNM staging were found to be correlated with PRS.

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Prognostic Value of the Naples Prognostic Score in Patients with Gastrointestinal Cancers: A Meta-Analysis

Chen

Xie

Ren

et al. 2023

Nutrition and Cancer

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The clinic factors in evaluating long-term outcomes of patients with stage I colorectal cancer

Cited by 6 publications

References 31 publications

Prognostic value of preoperative combined with postoperative systemic immune-inflammation index for disease-free survival after radical rectal cancer surgery: a retrospective cohort study

Prognostic value of preoperative combined with postoperative systemic immune-inflammation index for disease-free survival after radical rectal cancer surgery: a retrospective cohort study

Post recurrence survival in early versus late period and its prognostic factors in rectal cancer patients

Prognostic Value of the Naples Prognostic Score in Patients with Gastrointestinal Cancers: A Meta-Analysis

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