The clinical and experimental substantiation of bacteriophages and oxygenated preparation application in disseminated peritonitis complicated with enteral insufficiency

Abstract

8. Лубянский В. Г., Сероштанов В. В. Результаты дуоденумсохраняющих резекций поджелудочной железы при хроническом панкреатите с применением технологий герметизации панкреатокишечного анастомоза. Acta Biomedica Scientifica. 2019;4(2):122-126. [Lubyanskii V. G., Seroshtanov V. V. The results of duodenum-preserving resections of the pancreas in chronic pancreatitis using the technology of sealing the pancreatic-intestinal anastomosis. Acta Biomedica Scientifica. 2019;4(2):122-126. (In Russ.)].

Polyvalent Bacteriophages and Oxygenated Water – Possibilities for Prevention of Surgical Site Infection During Emergency Abdominal Surgery

“…Figure 1. Change in the transluminal enteral pathobiome in study groups (×10 [1][2][3][4][5][6][7][8][9][10] CFU in 1 мl)…”

“…Indeed, phages have several important advantages that contribute to their therapeutic and prophylactic potential: high specificity, rapid inactivation after eradication of the pathogen, the ability to replicate, immune stimulation, the ability to penetrate through the matrix of biofilm infections, inactivity towards human tissues, the possibility of local and oral applications, etc. Recently, intensively developing phage therapy has brought about life-saving therapeutic cases and numerous clinical trials [5][6][7][8][9].…”

Results of the Use of Polyvalent Bacteriophages in the Treatment of Infectious Complications in Emergency Abdominal Surgery

“…These cross coupling interactions have a great influence on the formation of the function of the host's immune system and, ultimately, on the outcome of interventions. Evidence suggests that pathogens derived from the gut microbiota can cause postoperative infection while they stealthily travel inside an immune cell and contaminate a remote surgical site (Trojan horse hypothesis) [4][5][6][7][8].…”