The Clinical and Immunologic Responses of Normal Human Volunteers to Low Dose Hookworm (Necator americanus) Infection

Maxwell, Celia; Hussain, Rabia; Nutman, Thomas B.; Poindexter, Robert W.; Little, M. D.; Schad, Gerhard A.; Ottesen, Eric A.

doi:10.4269/ajtmh.1987.37.126

Cited by 141 publications

(110 citation statements)

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“…For example, volunteers infected with N. americanus produce antibodies against both larval and adult worms (Ball & Bartlett, 1969;Ogilvie et al 1978), and a number of antigens are recognized by a range of sera from infected patients Pritchard et al 1986). Cellular responses, including a pronounced eosinophilia, are also associated with hookworm infection (Grove, Burston & Forbes, 1974;Taylor & Turton, 1976;White, Maxwell & Gallin, 1986;Maxwell et al 1987).…”

Section: Introductionmentioning

confidence: 99%

Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens

et al. 1990

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SUMMARYBaseline data from an immuno-epidemiological study of hookworm infection in a rural village in Madang Province, Papua New Guinea are reported. Necator americanus was found to be the commonest helminth infection, with a prevalence of near 100% and intensity of 40 worms per host in adults. Enterobius vermicularis, Ascaris lumbricoides and Trichuris trichiura were also present, at prevalences of 53, 10 and 3% respectively; Ancylostoma duodenale was absent. The frequency distribution of N. americanus was highly over-dispersed, and was well described by a negative binomial distribution with aggregation parameter, k, of 0-370. Intensity of infection was significantly related to host age, but did not differ between the sexes. Haemoglobin levels and haematocrit values were indicative of anaemia in the community, but were unrelated to hookworm infection. Levels of antibodies (IgG, IgA and IgM combined) against adult Necator cuticular collagen and excretory-secretory (ES) products were determined. Serum concentrations of the two types of antibody were significantly correlated with each other. Significant positive correlations were found between anti-ES antibody levels and hookworm egg production, and between anti-collagen antibody levels and host age. It is suggested that the level of anti-collagen antibodies may reflect cumulative exposure to infection, whereas levels of anti-ES antibodies may be more dependent on current worm burden. No evidence was found to suggest that either antibody response is important in regulating parasite population growth. Similarly, the presence of a positive correlation between eosinophil concentration and infection intensity in adults indicates that eosinophilia reflects, rather than determines, the host's worm burden.

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Section: Introductionmentioning

confidence: 99%

Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens

et al. 1990

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“…Kancalı kurt olarak tanımlanan Necator americanus tedavi edici bir helment olarak bazı çalışmalarda değerlendirilmiştir (18) . Akut infeksiyonu ile vücudun pek çok yerinden geçiş sağ-layan bu helment otoimmun hastalıkların tedavisinde oldukça etkili olmuştur.…”

Section: İnsanlarda Parazit Tedavileriunclassified

Usage of Parasites as Alternative Therapy

Yereli¹

2012

Ankem Derg

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“…Saturated-salt solution floatation technique was found to be particularly effective in the concentration of Ascaris and simple sedimentation was found particularly effective in the concentration of eggs of Taenia spp. [18][19][20][21][22].…”

Section: Table 3-sex-wise Prevalence Of Intestinal Parasites In Hiv-pmentioning

confidence: 99%

“…Collection of Stool-The following essentials were fulfilled:  Sterile universal container was used or a clean and dry container  Patient was instructed not to mix urine with stool sample Oil, oily emulsion, barium or bismuth salts were not given to the patients before stool examination [22][23][24][25][26].…”

Section: Stool Examinationmentioning

confidence: 99%

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Comparative Study of the Prevalence of Intestinal Parasites in Hiv-Reactive and Non-Reactive Individuals From Maharashtra India

Ujagare¹,

Jadhav²,

Bawal³

et al. 2012

Int J Parasitol Res

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The Clinical and Immunologic Responses of Normal Human Volunteers to Low Dose Hookworm (Necator americanus) Infection

Cited by 141 publications

References 0 publications

Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens

Epidemiology and immunology of Necator americanus infection in a community in Papua New Guinea: humoral responses to excretory-secretory and cuticular collagen antigens

Usage of Parasites as Alternative Therapy

Comparative Study of the Prevalence of Intestinal Parasites in Hiv-Reactive and Non-Reactive Individuals From Maharashtra India

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