The Clinical Characteristics, Severity, and Seasonality of RSV Subtypes Among Hospitalized Children in Jordan

Abstract

Supplemental Digital Content is available in the text.

Respiratory Syncytial Virus: New Challenges for Molecular Epidemiology Surveillance and Vaccination Strategy in Patients with ILI/SARI

“…Unfortunately, to the best of our knowledge, there are no published studies focusing on adults, which could confirm this hypothesis. Anyway, it is useful to recall that other epidemiological investigations reported conflicting results on the severity profiles due to subgroup A or B viruses [46][47][48].…”

Seasonality, Clinical Characteristics, and Outcomes of Respiratory Syncytial Virus Disease by Subtype Among Children Aged <5 Years: New Vaccine Surveillance Network, United States, 2016–2020

“…However, in the 2019–2020 season, RSV-A accounted for nearly 85% of detections. Seasonality with dominance of 1 subtype, as demonstrated in this analysis of data from the NVSN, has been observed in different regions of the world [ 1–3 , 10 , 11 , 13 , 14 ]. The dominance of RSV-A during the 2019–2020 season and changes presented in the amino acid structure of RSV/A/ON recorded between 2012 and 2018 may have impacted trends in RSV circulation in subsequent years, potentially due to subtype-specific immunity [ 12 ].…”

“…A typical RSV season in much of the United States occurs annually from late fall through early spring, with a peak during winter [ 2 , 8 , 9 ]. Each season, RSV subtypes have been known to cocirculate with natural variability of subtype predominance over time in different regions of the world [ 10–14 ]. To date, clinical associations with viral subtype have been studied primarily among hospitalized children only, with conflicting findings such that no conclusive relationships between RSV subtype and severity have been established [ 6 ], although differences in clinical presentation have been reported [ 9 ].…”

Characterisation of RSV infections in children without chronic diseases aged 0–36 months during the post-COVID-19 winter season 2022/2023

“…Hence, the initial curb of infections in 0-36-month-olds could have potentially resulted in this wave of RSV cases in late November/early December 2022 and increased hospitalisation rates, as also recorded by the US RSV Network (20, 21). The literature offers limited data on the severity and course of RSV infections in primary health care settings, as many studies have focused on the outpatient setting or hospitalised patients (2,10,11,21,22). In the first years of life, infants face a significant burden due to RSV in both inpatient and outpatient settings (23)(24)(25).…”

“…As the virus evolves, new variants continuously develop while others disappear. Whether and to what extent the two RSV types influence seasonality, transmission rate, rate of co-infection, and severity of virus-associated disease is controversially discussed in the literature (10)(11)(12).…”