The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine

Jakoi, Ande M.; Pannu, Gurpal; D’Oro, Anthony; Buser, Zorica; Pham, Martin H.; Patel, Neil N.; Hsieh, Patrick C.; Liu, John C.; Acosta, Frank L.; Hah, Raymond J.; Wang, Jeffrey C.

doi:10.4184/asj.2017.11.3.337

Cited by 52 publications

(46 citation statements)

References 61 publications

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“…Many evidences showed that diabetes mellitus (DM) is a dependent risk factor in the progression of IVDD . Previous epidemiological investigations have reported that DM patients have a higher incidence of IVDD than the patients without DM, and that DM patients with IVDD are also much younger than non‐DM patients . It has been demonstrated that high glucose can accelerate autophagy, apoptosis, and senescence of adult rat NP cells in a dose‐ and time‐dependent manner .…”

Section: Introductionmentioning

confidence: 99%

The effect of high glucose on the biological characteristics of nucleus pulposus‐derived mesenchymal stem cells

Liu

et al. 2020

Cell Biochemistry & Function

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Diabetes mellitus (DM) is a dependent risk factor in the progression of intervertebral disc degeneration (IVDD). High glucose supply has negative effects on nucleus pulpous (NP) cell and mesenchymal stem cell (MSC) biology. However, the effect of hyperglycaemia on the biological characterization of nucleus pulpous-derived mesenchymal stem cell (NPMSC) has not been investigated previously. Therefore, further exploration of the effects of DM-associated hyperglycaemia on NPMSC biology is important to better understand and develop endogenous repair strategies of DM patient-associated IVDD. Therefore, the cell biological characteristics were compared between NPMSC cultured in media with low glucose concentration (LG-NPMSC) and high glucose concentration (HG-NPMSC). The results demonstrated that HG-NPMSC showed significantly decreased cell proliferation, colony formation ability, migration and wound-healing capability compared with those of LG-NPMSC. HG-NPMSC also showed significantly decreased expressions of stemness genes and mRNA and protein expressions of silent information regulator protein 1 (SIRT1), SIRT6, hypoxia inducible factor-1α (HIF-1α) and glucose transporter 1 (GLUT-1), whereas increased cell apoptosis, cell senescence and caspase-3 expression. These results suggest that high glucose may decrease proliferation and stemness maintenance ability and increase apoptosis and senescence of NPMSC.Significance of the study: We found that high glucose concentration significantly decreased cell proliferation, colony formation ability, migration and wound-healing capability of nucleus pulposus-derived mesenchymal stem cells. Moreover, high glucose cultured nucleus pulposus-derived mesenchymal stem cells showed significantly decreased expression of stemness genes, related mRNA and protein, whereas increased cell apoptosis, cell senescence and expression of caspase-3. The present study indicated that better control of high concentration glucose in the early stage of diabetes mellitus should be recommended to prevent or limit intervertebral disc degeneration. K E Y W O R D S-high glucose, nucleus pulposus-derived mesenchymal stem cells, proliferation, apoptosis, senescence

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Section: Introductionmentioning

confidence: 99%

The effect of high glucose on the biological characteristics of nucleus pulposus‐derived mesenchymal stem cells

Liu

et al. 2020

Cell Biochemistry & Function

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“…Consequently, it is a clinical priority to identify ways to reduce IVD damage. Risk factors for IVD degeneration are multifactorial, and recent studies have shown that Diabetes Mellitus (DM), obesity or being overweight add significant morbidity to back pain and IVD degeneration (Liuke et al, 2005, Takatalo et al, 2013, Jakoi et al, 2017, Fabiane et al, 2016 as they increase the risk for herniation (Sakellaridis, 2006), spinal stenosis (Anekstein et al, 2010) and spinal surgery complications (Guzman et al, 2014). DM and obesity are increasing at alarming rates, making this a growing high-risk population.…”

Section: Introductionmentioning

confidence: 99%

Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs

Krishnamoorthy

Hoy

Natelson

et al. 2018

Preprint

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StatementDietary advanced glycation end-products (AGE) lead to sex-specific intervertebral disc structural and functional changes and may be targeted for promoting spinal health especially in diabetes where AGEs form rapidly. ABSTRACTBack pain is a leading cause of disability strongly associated with intervertebral disc (IVD) degeneration. Reducing structural disruption and catabolism in IVD degeneration remains an important clinical challenge. Pro-oxidant and structuremodifying advanced glycation end-products (AGEs) contribute to obesity and diabetes, which are associated with increased back pain, and accumulate in tissues due to hyperglycemia or ingestion of foods processed at high heat.Collagen-rich IVDs are particularly susceptible to AGE accumulation due to their slow metabolic rates yet it is unclear if dietary AGEs can cross the endplates to accumulate in IVDs. We apply a dietary mouse model to test the hypothesis that chronic consumption of high AGE diets results in sex-specific IVD structural disruption and functional changes. High AGE diet resulted in AGE accumulation in IVDs and increased IVD compressive stiffness, torque range, and failure torque, particularly for females. These biomechanical changes were likely caused by significantly increased AGE crosslinking in the annulus fibrosus, measured by multiphoton imaging. Increased collagen damage measured with collagen hybridizing peptide may be a risk factor for IVD degeneration as these animals age. The greater influence of high AGE diet on females is an important area of future investigation that may involve AGE receptors, known to interact with estrogen. We conclude high AGE diets can be a source for IVD crosslinking and collagen damage known to be important in IVD degeneration. This suggests dietary and other interventions that modify AGEs warrant further investigation and may be particularly important for diabetics where AGEs accumulate more rapidly.

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“…Smoking, obesity and diabetes mellitus are positively correlated with DDD. Of the 3 factors, smoking is the highest correlations to DDD and their effect is synergistic [62]. ADAMTS5 is the primary aggrecanase found in animal study that mediating smoking-induced disc aggrecanolysis and DDD [63].…”

Section: Environmental and Psychosocial Factors Associated With Dddmentioning

confidence: 97%

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

Kim

Jang

2020

IJMS

101

114

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Degenerative disc disease is a leading cause of chronic back pain in the aging population in the world. Sinuvertebral nerve and basivertebral nerve are postulated to be associated with the pain pathway as a result of neurotization. Our goal is to perform a prospective study using radiofrequency ablation on sinuvertebral nerve and basivertebral nerve; evaluating its short and long term effect on pain score, disability score and patients’ outcome. A review in literature is done on the pathoanatomy, pathophysiology and pain generation pathway in degenerative disc disease and chronic back pain. 30 patients with 38 levels of intervertebral disc presented with discogenic back pain with bulging degenerative intervertebral disc or spinal stenosis underwent Uniportal Full Endoscopic Radiofrequency Ablation application through either Transforaminal or Interlaminar Endoscopic Approaches. Their preoperative characteristics are recorded and prospective data was collected for Visualized Analogue Scale, Oswestry Disability Index and MacNab Criteria for pain were evaluated. There was statistically significant Visual Analogue Scale improvement from preoperative state at post-operative 1wk, 6 months and final follow up were 4.4 ± 1.0, 5.5 ± 1.2 and 5.7 ± 1.3, respectively, p < 0.0001. Oswestery Disability Index improvement from preoperative state at 1week, 6 months and final follow up were 45.8 ± 8.7, 50.4 ± 8.2 and 52.7 ± 10.3, p < 0.0001. MacNab criteria showed excellent outcomes in 17 cases, good outcomes in 11 cases and fair outcomes in 2 cases Sinuvertebral Nerve and Basivertebral Nerve Radiofrequency Ablation is effective in improving the patients’ pain, disability status and patient outcome in our study.

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The Clinical Correlations between Diabetes, Cigarette Smoking and Obesity on Intervertebral Degenerative Disc Disease of the Lumbar Spine

Cited by 52 publications

References 61 publications

The effect of high glucose on the biological characteristics of nucleus pulposus‐derived mesenchymal stem cells

The effect of high glucose on the biological characteristics of nucleus pulposus‐derived mesenchymal stem cells

Dietary Advanced Glycation End-Product Consumption Leads to Mechanical Stiffening of Murine Intervertebral Discs

Lumbar Degenerative Disease Part 1: Anatomy and Pathophysiology of Intervertebral Discogenic Pain and Radiofrequency Ablation of Basivertebral and Sinuvertebral Nerve Treatment for Chronic Discogenic Back Pain: A Prospective Case Series and Review of Literature

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