The clinical feasibility and performance of an orthogonal X-ray imaging system for image-guided radiotherapy in nasopharyngeal cancer patients: Comparison with cone-beam CT

Zhao, Liang; Zhou, Yinghao; Li, Guanghui; Li, Qi Ming; Yang, Dezhong; Li, Hanxu; Jiu-qing, Wan; Sun, Jianping

doi:10.1016/j.ejmp.2015.11.010

Cited by 8 publications

(7 citation statements)

References 34 publications

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“…1,2 Since X-rays were first discovered in 1895, radiation has been widely used for cancer therapy; today, over 40% of patients with cancer undergo RT. 3,4 However, in recent years, many concerns regarding acute and chronic radiological toxicity, in particular hematological toxicity (HT), have emerged. Narendra et al reported that treatment interruptions among patients with medulloblastoma receiving craniospinal irradiation happened due to acute HT of RT.…”

Section: Introductionmentioning

confidence: 99%

Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

et al. 2019

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Background: Radiation therapy induces acute and chronic radiological toxicity, in particular hematological toxicity (HT). This study aimed to explore the mechanistic clue and potential predictors at the messenger RNA (mRNA) level. Materials and Methods: Peripheral blood was collected from 3 patients with cervical cancer (CC), nasopharynx cancer (NC), and tongue cancer (TC) after the first 2 Gy fraction of radiotherapy (RT). High-throughput sequencing was used to assess mRNA profiles. Results: Eleven genes, such as ALAS2(5-aminolevulinate synthase), SLC4A1(solute carrier family 4 member 1), HBG2 (hemoglobin subunit gamma 2), TNFAIP3 (TNF α-induced protein 3), PER1 (period circadian clock 1), CCDC136 (coiled-coil domain containing 136), C9orf84 (chromosome 9 open reading frame 84), IL1B (interleukin 1β), FOSB (FosB protooncogene), NR4A2 (nuclear receptor subfamily 4), PARP15 (polymerase family member 15), had overlapping expression changes in all 3 cancers of which 3 ( ALAS2 , FOSB, and HBG2 ) are suggested as potential predictors for the early diagnosis of HT after RT. Conclusions: ALAS2, FOSB, and HBG2 may be useful predictors of HT in patients after RT. Eleven overlapping expression mRNAs among 3 cancers might be potential predictors for early diagnosis of radiation toxicity in patients.

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Section: Introductionmentioning

confidence: 99%

Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

et al. 2019

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“…The top three subspecialties are radiation imaging (218 papers), radiation therapy (70 papers), and magnetic resonance (42 papers). Within the subspecialty of radiation therapy, the number of publications are 15 papers in the field of clinical implementation [41][42][43][44][45][46][47][48][49][50][51][52][53][54][55], 11 papers in the field of plan optimization [56][57][58][59][60][61][62][63][64][65][66], 14 papers in the field of plan evaluation [67][68][69][70][71][72][73][74][75][76][77][78][79][80], and 12 papers in the field of quality assurance [81][82][83][84][85][86][87][88]…”

Section: Scientific Researchmentioning

confidence: 99%

The status of medical physics in radiotherapy in China

Yan

Huang

et al. 2021

Physica Medica

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To present an overview of the status of medical physics in radiotherapy in China, including facilities and devices, occupation, education, research, etc. Materials and methods: The information about medical physics in clinics was obtained from the 9-th nationwide survey conducted by the China Society for Radiation Oncology in 2019. The data of medical physics in education and research was collected from the publications of the official and professional organizations. Results: By 2019, there were 1463 hospitals or institutes registered to practice radiotherapy and the number of accelerators per million population was 1.5. There were 4172 medical physicists working in clinics of radiation oncology. The ratio between the numbers of radiation oncologists and medical physicists is 3.51. Approximately, 95% of medical physicists have an undergraduate or graduate degrees in nuclear physics and biomedical engineering. 86% of medical physicists have certificates issued by the Chinese Society of Medical Physics. There has been a fast growth of publications by authors from mainland of China in the top international medical physics and radiotherapy journals since 2018. Conclusions: Demand for medical physicists in radiotherapy increased quickly in the past decade. The distribution of radiotherapy facilities in China became more balanced. High quality continuing education and training programs for medical physicists are deficient in most areas. The role of medical physicists in the clinic has not been clearly defined and their contributions have not been fully recognized by the community.Prof. Xu Haichao in 1940s at Peking Union Medical College (PUMC). He worked with Prof. Marvin Williomus, an American medical physicist, to treat cancer patients using a 400 kV X-ray unit [7]. The department of radiology in Caner Institute of Chinese Academy of Medical Sciences (CICAMS) started to treat patients with a Cobalt-60 unit in 1958. At the same year, the division of radiation physics in CICAMS was founded. They made the manual multi-leaf collimator and installed it on Cobalt-60 machine in 1965. Later, they made the remote control system for brachytherapy machine using Cobalt-60 source ball in 1965Cobalt-60 source ball in -1967.From 1970, China began to build linear accelerators and on-board imaging devices. As a result, 25 MeV Betatron, Simulator and Cobalt-60 brachytherapy machine were produced by Tianjing therapeutic instrument factory [9]. Meanwhile, Beijing Medical Apparatus and Instruments Institute built the first linear accelerator [10]. Since 1976, the major hospitals started to purchase high-end linear accelerators, CT, Brachytron and planning software from USA and Europe [11]. Following the clinical application of the linear accelerators, text books in Chinese

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“…HNC image registrations have reported good correlation in translational shifts between 2D and 3D image matches [74][75][76]. Shifts from 3D bony matched images have reported similar results to those from 2D images [47,77] and standard planning margins provide adequate soft tissue coverage in HNC patients where IGRT matches are based on bone [78]. Bone based matches in HNC produce similar dosimetric outcomes to implanted fiducial matching [79].…”

Section: D Imagingmentioning

confidence: 99%

A review of Image Guided Radiation Therapy in head and neck cancer from 2009–2019 – Best Practice Recommendations for RTTs in the Clinic

Kearney

Coffey

Leong

2020

Technical Innovations & Patient Support in Radiation Oncolo

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Radiation therapy (RT) is beneficial in Head and Neck Cancer (HNC) in both the definitive and adjuvant setting. Highly complex and conformal planning techniques are becoming standard practice in delivering increased doses in HNC. A sharp falloff in dose outside the high dose area is characteristic of highly complex techniques and geometric uncertainties must be minimised to prevent under dosage of the target volume and possible over dosage of surrounding critical structures. CTV-PTV margins are employed to account for geometric uncertainties such as set up errors and both interfraction and intrafraction motion. Robust immobilisation and Image Guided Radiation Therapy (IGRT) is also essential in this group of patients to minimise discrepancies in patient position during the treatment course. IGRT has evolved with increased 2-Dimensional (2D) and 3-Dimensional (3D) IGRT modalities available for geometric verification. 2D and 3D IGRT modalities are both beneficial in geometric verification while 3D imaging is a valuable tool in assessing volumetric changes that may have dosimetric consequences for this group of patients. IGRT if executed effectively and efficiently provides clinicians with confidence to reduce CTV-PTV margins thus limiting treatment related toxicities in patients. Accumulated exposure dose from IGRT vary considerably and may be incorporated into the treatment plan to avoid excess dose. However, there are considerable variations in the application of IGRT in RT practice. This paper aims to summarise the advances in IGRT in HNC treatment and provide clinics with recommendations for an IGRT strategy for HNC in the clinic.

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The clinical feasibility and performance of an orthogonal X-ray imaging system for image-guided radiotherapy in nasopharyngeal cancer patients: Comparison with cone-beam CT

Cited by 8 publications

References 34 publications

Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

Analysis of mRNA Expression Patterns in Peripheral Blood Cells of 3 Patients With Cancer After the First Fraction of 2 Gy Irradiation: An Integrated Case Report and Systematic Review

The status of medical physics in radiotherapy in China

A review of Image Guided Radiation Therapy in head and neck cancer from 2009–2019 – Best Practice Recommendations for RTTs in the Clinic

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