The Clinical Features and Predisposing Factors of Asymptomatic Erosive Esophagitis

Lee, Sang Pyo; Sung, In‐Kyung; Kim, Jeong Hwan; Lee, Sun-Young; Park, Hyung Seok; Shim, Chan Sup

doi:10.1007/s10620-016-4341-9

Cited by 12 publications

(11 citation statements)

References 27 publications

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“…Gastroesophageal reflux disease (GERD) is increasing, affecting up to 17% of the population in Asian countries and up to 40% in Western countries . The condition becomes apparent when contents of the gastric juice, specifically pepsin, leave the stomach and backflow into the esophagus, often causing damage and a myriad of symptoms including heartburn .…”

Section: Introductionmentioning

confidence: 99%

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Validation in China of a non‐invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease

Wang

Yang

Chen

et al. 2019

J of Digest Diseases

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ObjectivesPeptest is a new non‐invasive reflux diagnostic test based on lateral flow technology that containing two highly specific human pepsin monoclonal antibodies for detecting pepsin, a biomarker for reflux disease. The primary aim of this multicenter clinical study was to validate the efficacy of Peptest in patients diagnosed with gastroesophageal reflux and healthy controls in China.MethodsPatients with suspected gastroesophageal reflux underwent an endoscopy and were classified into non‐erosive reflux disease and erosive esophagitis subgroups. A healthy control group was also recruited. All participants were given a reflux disease questionnaire—patients scoring greater than 12 and controls scoring zero. All participants provided a postprandial saliva sample and most patients gave an additional post‐symptom sample for pepsin analysis.ResultsAltogether 1032 participants aged between 19 and 78 years were recruited. They consisted of 488 patients with non‐erosive reflux disease, 221 with erosive esophagitis and 323 healthy controls. The number of postprandial and post‐symptom samples analyzed totaled 1031 and 692, respectively. The results across all centers showed an overall pepsin‐positive sensitivity of 85%, a specificity of 60%, a positive predictive value of 82%, a negative predictive value of 65% and a positive likelihood ratio of 2.12.ConclusionThe sensitivity of Peptest was high, but the specificity achieved in some centers was low, resulting overall in only a moderate specificity. Further diagnostic investigative studies are warranted.

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Section: Introductionmentioning

confidence: 99%

“…EE affects only 30% of the GERD population but it is extremely serious. This subcategory causes damage and may lead to additional future complications including Barrett's esophagus and adenocarcinoma . Affecting up to 70% of patients with GERD, NERD is the most frequent form of reflux disease .…”

Section: Introductionmentioning

confidence: 99%

Validation in China of a non‐invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease

Wang

Yang

Chen

et al. 2019

J of Digest Diseases

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“…A recent study that was conducted in subjects attending health examinations in Taiwan reported that male sex and hiatus hernias were positive risk factors for silent GERD, while the active infection of H. pylori was negatively associated with the occurrence of silent GERD [ 7 ]. Male sex, a BMI over 25, smoking, and/or drinking were also reported to be positive or negative factors for the occurrence of asymptomatic esophagitis in other studies done in Korea [ 11 ].…”

Section: Discussionmentioning

confidence: 94%

“…It is common to observe silent GERD and hypertension concurrently, since many risk factors are shared by these two diseases. Risk factors including age, obesity, male sex, smoking, alcohol consumption, and education level have been reported to be significantly associated with both silent GERD and hypertension [ 11 – 17 ]. More importantly, previous studies have shown that silent GERD and hypertension not only coexist but they also mutually reinforce each other.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Predictors of Silent Gastroesophageal Reflux Disease in Patients with Hypertension

Liu

et al. 2018

Gastroenterology Research and Practice

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Background Gastroesophageal reflux disease (GERD) without symptoms or silent GERD can be easily missed in patients with hypertension. We aimed to investigate the prevalence of GERD, specifically the prevalence of silent GERD in hypertensive patients, and to explore its possible predictors. Methods Consecutive patients with hypertension referred to the cardiovascular clinic of Suining Central Hospital in 2016 were screened for this study. A Reflux Disease Questionnaire (RDQ) and an esophagogastroduodenoscopy (EGD) were employed for the evaluation of silent GERD. Included patients were divided into silent-GERD group and non-GERD control group. The demographic characteristics and antihypertensive agent prescriptions were collected and compared between the two groups. Results The prevalence of silent GERD and GERD in patients with hypertension was 15.1% and 31.4%, respectively. 66 patients were included in the silent-GERD group, and 298 patients were included in the non-GERD control group. Abdominal obesity and untreated hypertension were positive predictors, while controlled hypertension was a negative predictor for silent GERD. The prescription of calcium channel blockers was not a predictor for it. Conclusions High prevalence of GERD, specifically silent GERD, could be found in patients with hypertension. Abdominal obesity and untreated hypertension were positive predictors for silent GERD, while controlled hypertension was a negative predictor for it.

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“…По этиологическому признаку выделяются эзофагиты [1]: ■ Поражения при ГЭРБ (наиболее частая причина). ■ Инфекционные -вирусные, грибковые, бактериальные.…”

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Principles of Management of Chronic Ezophagitis of Various Etiologies

Plotnikova¹,

Вологжанина²,

Igumnova³

et al. 2017

Med. sov.

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The Clinical Features and Predisposing Factors of Asymptomatic Erosive Esophagitis

Abstract: KCT0001716.

Cited by 12 publications

References 27 publications

Validation in China of a non‐invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease

Validation in China of a non‐invasive salivary pepsin biomarker containing two unique human pepsin monoclonal antibodies to diagnose gastroesophageal reflux disease

Prevalence and Predictors of Silent Gastroesophageal Reflux Disease in Patients with Hypertension

Principles of Management of Chronic Ezophagitis of Various Etiologies

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