The clinical significance of integrin subunit alpha V in cancers: from small cell lung carcinoma to pan-cancer

Abstract

Background Little is known about the relationship between integrin subunit alpha V (ITGAV) and cancers, including small cell lung cancer (SCLC). Methods Using large sample size from multiple sources, the clinical roles of ITGAV expression in SCLC were explored using differential expression analysis, receiver operating characteristic curves, Kaplan–Meier curves, etc. Results Decreased mRNA (SMD = − 1.05) and increased protein levels of ITGAV were detected in SCLC (n = 865). Transcription factors—ZEB2, IK2F1, and EGR2—may regulate ITGAV expression in SCLC, as they had ChIP-Seq (chromatin immunoprecipitation followed by sequencing) peaks upstream of the transcription start site of ITGAV. ITGAV expression made it feasible to distinguish SCLC from non-SCLC (AUC = 0.88, sensitivity = 0.78, specificity = 0.84), and represented a risk role in the prognosis of SCLC (p < 0.05). ITGAV may play a role in cancers by influencing several immunity-related signaling pathways and immune cells. Further, the extensive pan-cancer analysis verified the differential expression of ITGAV and its clinical significance in multiple cancers. Conclusion ITGAV served as a potential marker for prognosis and identification of cancers including SCLC.

Biomimetic fractal topography enhances podocyte maturation in vitro

“…10 ). Intriguingly, these genes, which were specifically higher in RT than in HF were reported to be upregulated in cancers in general and more specifically in renal cancers ( COL12A1, 41,42 COL5A1, 43 COL5A2 44 and MMP17 45 ) and other kidney diseases such as: acute kidney injury ( MAP3K14 46 ), focal segmental glomerulosclerosis ( COL4A2 47 ), renal fibrosis ( ITGAV 48,49 ) and polycystic kidney disease ( ITGB1 50 ). This indicates that although topography generally results in the upregulation of ECM, cell-matrix attachment and cytoskeletal re-arrangement genes in comparison to the flat substrates, a more physiologically relevant topography such as HF, prevents overactivation of genes that are often linked to pathological conditions such as cancer.…”

Genes diferencialmente expresados en cáncer de pulmón de células pequeñas: Potenciales dianas terapéuticas

“…Por otro lado, genes que regulan la proliferación celular y la reparación de tejidos, como ITGAV, ISL1, HMGN2, STMN1, ACYP1, FGFR1 y PLCG1 mostraron una alta expresión. Esta sobreexpresión estuvo relacionada con un mal pronóstico y una aumento en la proliferación celular (14,6,26,35) . Finalmente, genes supresores de tumores como TP53, RB1, DLL3 y XPO1 mostraron un papel fundamental en la oncogénesis del SCLC.…”

Small molecule– and peptide–drug conjugates addressing integrins: A story of targeted cancer treatment

“…[ 142 ] One reason for the frequent occurrence of this subunit could be its participation in immunity‐related signalling pathways in some cancers. [ 143 ] However, overexpression and involvement in cancer (see Table 3.1) generally make integrins a promising target for targeted cancer therapy through treatment with agonistic/antagonistic ligands or as a target receptor for drug delivery systems such as PDCs, SMDCs and ADCs.…”