The clinical signification and application value of [68Ga]Ga-PSMA imaging in thyroid malignancy

Feng, Yu Yue; Shi, Yang Rui; Xia, Zhu; Xu, Lu; Li, Wen Bo; Pang, Hua; Wang, Zheng jie

doi:10.1007/s12020-023-03599-x

Cited by 5 publications

(4 citation statements)

References 33 publications

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“…Regarding the diagnostics of DTC, recent IHC and molecular imaging studies explored the in vitro and in vivo expression of prostate-specific membrane antigen (PSMA, also known as carboxypeptidase type II), reporting a variable expression of this transmembrane protein on the surface of neo endothelial cells within tumour’s neo angiogenesis and conflicting results concerning the potential employment of PSMA-targeted PET in DTC patients ( 46 – 48 ). Given the lack of existing literature comparing these two tracers in DTC patients and the recent development of bispecific radiopharmaceuticals designed to target both FAP and PSMA, it is necessary to conduct prospective studies encompassing both diagnostic methods in order to assess which instrumental examination is more dependable for this type of malignancy ( 49 ).…”

Section: Discussionmentioning

confidence: 99%

Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review

Rizzo,

Albano,

Dondi

et al. 2024

Front. Med.

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BackgroundSeveral recent studies have proposed the possible application of positron emission tomography/computed tomography (PET/CT) administering radiolabelled fibroblast-activation protein (FAP) inhibitors for various forms of thyroid cancer (TC), including differentiated TC (DTC), and medullary TC (MTC).MethodsThe authors conducted an extensive literature search of original studies examining the effectiveness of FAP-guided PET/CT in patients with TC. The papers included were original publications exploring the use of FAP-targeted molecular imaging in restaging metastatic DTC and MTC patients.ResultsA total of 6 studies concerning the diagnostic yield of FAP-targeted PET/CT in TC (274 patients, of which 247 DTC and 27 MTC) were included in this systematic review. The included articles reported high values of FAP-targeted PET/CT detection rates in TC, ranging from 81 to 100% in different anatomical sites and overall superior to the comparative imaging method.ConclusionAlthough there are promising results, the existing literature on the diagnostic accuracy of FAP-guided PET in this context is still quite limited. To thoroughly evaluate its potential significance in TC patients, it is needed to conduct prospective randomized multicentric trials.

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Section: Discussionmentioning

confidence: 99%

Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review

Rizzo,

Albano,

Dondi

et al. 2024

Front. Med.

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“…30 In addition to FAPI, studies have shown that the expression of prostate-specific membrane antigen (PSMA) is related to the degree of differentiation of thyroid cancer and may indicate the persistence and recurrence of thyroid cancer. 31 , 32 Numerous guidelines exist for thyroid cancer, and reference standards are inconsistent. Our study provides a reference for imaging, especially for individuals with an intermediate risk of recurrence, where PET/CT examination is highly significant.…”

Section: Discussionmentioning

confidence: 99%

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Fan,

Zhang,

Wang

et al. 2024

DIGITAL HEALTH

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Purpose This study aims to evaluate the diagnostic value of texture analysis for lymph node metastasis after thyroid cancer surgery. Methods We retrospectively analyzed patients who underwent positron emission tomography/computed tomography (PET/CT) examination before 131I treatment at Shanghai Tenth People's Hospital between 2017 and 2020. Clinical follow-up results were used as the criterion for determining the presence of lymph node metastasis. The study included 119 patients, who were then randomly divided into training and test groups in a 7:3 ratio. Regions of interest were identified, and radiomics features were extracted using LIFEx 7.3.0. Mann–Whitney U test and LASSO regression were employed to screen radiomics parameters for modeling. Subsequently, a nomogram model was built by combining radscore and clinical features. SPSS 26.0 software was utilized for statistical analysis, and p < 0.05 was considered statistically significant. Results Follow-up confirmed 54 patients with thyroid cancer lymph node metastasis and 65 patients in the non-metastasis group. A total of 119 lymph nodes were delineated. For each lesion, 164 CT texture features and 164 PET texture features were extracted, and 107 significant parameters were identified, including 16 CT texture parameters and 91 PET texture parameters. After screening, 3 CT parameters, 4 PET parameters and 12 PET/CT parameters were selected to establish three radiomic models. The AUC values were as follows: AUC (CT) = 0.730, AUC (PET) = 0.759 and AUC (PET/CT) = 0.864. We then combined clinical features and radscore to construct a nomogram, resulting in a C-index of 0.915 in the training group. In the test group, the C-index was confirmed to be 0.868. Conclusions Radiomics may enhance the diagnostic efficiency of lymph node metastases after thyroid cancer surgery and could potentially assist clinicians in future diagnoses. The developed nomogram, which combines radiomics and clinical features, offers relatively high accuracy in helping clinicians assess the risk of metastasis in thyroid patients after surgery.

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“…Feng et al conducted a comprehensive investigation employing Western blot, PCR, and [68Ga]Ga-PSMA uptake experiments on cell lines, complemented by in vivo small animal imaging [8]. Their study revealed a significant correlation between 68 Ga-PSMA imaging and tumor burden, as evidenced by correlations with 18 F-FDG PET/CT (8.08 ± 7.74 and 5.67 ± 4.23, p = 0.01) and thyroglobulin (Tg) levels (307.1 ± 183.4 vs. 118.0 ± 116.1, p = 0.002).…”

Section: Prostate-specific Membrane Antigen-based Radiotracers For Di...mentioning

confidence: 99%

Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer

Coerts,

de Keizer,

Verburg

2024

Cancers

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Thyroid cancer poses a significant challenge in clinical management, necessitating precise diagnostic tools and treatment strategies for optimal patient outcomes. This review explores the evolving field of radiotracers in the diagnosis and management of thyroid cancer, focusing on prostate-specific membrane antigen (PSMA)-based radiotracers, fibroblast activation protein inhibitor (FAPI)-based radiotracers, Arg-Gly-Asp (RGD)-based radiotracers, and 18F-tetrafluoroborate (18F-TFB). PSMA-based radiotracers, initially developed for prostate cancer imaging, have shown promise in detecting thyroid cancer lesions; however, their detection rate is lower than 18F-FDG PET/CT. FAPI-based radiotracers, targeting fibroblast activation protein highly expressed in tumors, offer potential in the detection of lymph nodes and radioiodine-resistant metastases. RGD-based radiotracers, binding to integrin αvβ3 found on tumor cells and angiogenic blood vessels, demonstrate diagnostic accuracy in detecting radioiodine-resistant thyroid cancer metastases. 18F-TFB emerges as a promising PET tracer for imaging of lymph node metastases and recurrent DTC, offering advantages over traditional methods. Overall, these radiotracers show promise in enhancing diagnostic accuracy, patient stratification, and treatment selection in differentiated thyroid cancer, warranting further research and clinical validation. Given the promising staging capabilities of 18F-TFB and the efficacy of FAP-targeting tracers in advanced, potentially dedifferentiated cases, continued investigation in these domains is justified.

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The clinical signification and application value of [68Ga]Ga-PSMA imaging in thyroid malignancy

Cited by 5 publications

References 33 publications

Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review

Diagnostic yield of FAP-guided positron emission tomography in thyroid cancer: a systematic review

Diagnosing postoperative lymph node metastasis in thyroid cancer with multimodal radiomics and clinical features

Advances in the Development of Positron Emission Tomography Tracers for Improved Detection of Differentiated Thyroid Cancer

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