The clinical transition between pemphigus foliaceus and pemphigus vulgaris correlates well with the changes in autoantibody profile assessed by an enzyme-linked immunosorbent assay

Komai, Ayako; Amagai, Masayuki; Ishii, Ken; Nishikawa, Takeji; Chorzelski, T; Matsuo, Itsuro; Hashimoto, Takashi

doi:10.1046/j.1365-2133.2001.04227.x

Cited by 69 publications

(79 citation statements)

References 24 publications

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“…In contrast, there are only 3 reported cases of transition from PF to PV [1, 6, 7] and 3 cases of PV-PF overlap [4, 6]. The period of transition from PV to PF ranged from 6 months to 20 years with a median of 3 years.…”

Section: Discussionmentioning

confidence: 90%

“…A few cases have been reported in the literature. Earlier cases were confirmed by histology and immunoblotting [1,2,3,4,5,6] while the transition in more recent cases has been demonstrated by a change in desmoglein (Dsg) 1 and 3 autoantibody profile by Dsg ELISA testing [6,7,8,9,10,11]. We report 3 cases that showed transition from PV to PF confirmed by Dsg ELISA.…”

Section: Introductionmentioning

confidence: 82%

“…The majority of cases of transition from PV to PF were reported by the Japanese [1,2,3,6,7,8,9]. Most of the earlier cases were confirmed on immunoblotting during the PF stage [1,2,3, 6] while in the cases reported over the past 3 years, the change in autoantibody profile has been demonstrated using Dsg ELISA [6,7,8,9,10,11]. One recent case report of transition from PV to PF documented rising Dsg1 antibody levels and decreasing Dsg3 antibody levels by ELISA with subsequent disappearance of Dsg3 antibodies while on prednisolone and immunosuppressives [11].…”

Section: Discussionmentioning

confidence: 99%

“…In the literature, there are at least 16 reported cases of transition of PV to PF [1,2,3,4,5,6,7,8,9,10,11] including one that reverted to PV again [7] (table 1). In contrast, there are only 3 reported cases of transition from PF to PV [1, 6, 7] and 3 cases of PV-PF overlap [4, 6].…”

Section: Discussionmentioning

confidence: 99%

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Three Cases of Transition from Pemphigus vulgaris to Pemphigus foliaceus Confirmed by Desmoglein ELISA

Ng¹,

Thng²

2005

Dermatology

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We report 3 cases of pemphigus vulgaris (PV) confirmed by histology and direct and indirect immunofluorescence that showed transition to pemphigus foliaceus (PF) 2–4 years from the time of disease onset. Desmoglein (Dsg) ELISA testing of the sera from these 3 patients in the later stages of their disease showed the presence of anti-Dsg1 antibodies and the absence of anti-Dsg3 antibodies. These patients were on prednisolone and immunosuppressives at the time the sera were tested, and it is unclear if the transition from PV to PF is a permanent one or whether it is due to preferential suppression of Dsg3 antibodies below a certain threshold. Previously reported cases of transition from PV to PF and PF to PV are summarized.

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Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Three Cases of Transition from Pemphigus vulgaris to Pemphigus foliaceus Confirmed by Desmoglein ELISA

Ng¹,

Thng²

2005

Dermatology

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“…[19][20][21][22] Curiously, recent reports describe the rare transition of phenotype from PV to PF [23][24][25][26][27] and from PF to PV. 26,28,29 In addition, anti-Dsg1 autoantibodies, typical of PF, have been detected in serum samples from patients with PV. 2 Conversely, anti-Dsg3 autoantibodies have been detected in serum samples from patients with PF and FS.…”

Section: Arch Dermatol 2007;143(7):895-899mentioning

confidence: 99%

Endemic Pemphigus Vulgaris

et al. 2007

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Background: Investigators from Brasilia, Brazil, observed several patients with a mucocutaneous disease that resembles pemphigus vulgaris clinically and histologically but with epidemiological features of fogo selvagem. Our objective was to characterize antidesmoglein 3 and antidesmoglein 1 autoantibody profiles in these unique patients who reside in Goiânia and Brasilia, Brazil, known endemic regions of fogo selvagem.Observations: We performed serological evaluation of 8 patients with a mucocutaneous disease clinically and histologically consistent with pemphigus vulgaris, as well as 27 healthy relatives of patients with fogo selvagem who reside in these endemic areas. Serum samples from all 8 patients bound desmoglein 3 by cold immunoprecipita-tion and from 6 patients by enzyme-linked immunosorbent assay, while serum samples from 4 patients bound desmoglein 1 by cold immunoprecipitation and by enzyme-linked immunosorbent assay. Antidesmoglein 3 autoantibodies were detected in 4 of 27 healthy donors by cold immunoprecipitation and by enzyme-linked immunosorbent assay, whereas antidesmoglein 1 autoantibodies were detected in 6 individuals by cold immunoprecipitation and in 3 individuals by enzyme-linked immunosorbent assay. Conclusion:These findings provide serological evidence of a new endemic variant of pemphigus vulgaris.

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Frequency of Shifts Over Time in the Profile of Antidesmoglein Antibodies in Pemphigus Vulgaris

Weitz¹,

Bystryn²

2007

Arch Dermatol

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The clinical transition between pemphigus foliaceus and pemphigus vulgaris correlates well with the changes in autoantibody profile assessed by an enzyme-linked immunosorbent assay

Abstract: The clinical phenotype at each stage is defined by the anti-Dsg antibody profile in the serum of these pemphigus patients showing mixed features of PF and PV. In addition, ELISA using recombinant baculoproteins was particularly useful in distinguishing PF and PV.

Cited by 69 publications

References 24 publications

Three Cases of Transition from Pemphigus vulgaris to Pemphigus foliaceus Confirmed by Desmoglein ELISA

Three Cases of Transition from Pemphigus vulgaris to Pemphigus foliaceus Confirmed by Desmoglein ELISA

Endemic Pemphigus Vulgaris

Frequency of Shifts Over Time in the Profile of Antidesmoglein Antibodies in Pemphigus Vulgaris

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