2024
DOI: 10.1101/2024.08.02.24311399
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The Cognitive, Age, Functioning, and Apolipoprotein E4 (CAFE) Scorecard to Predict the Development of Alzheimer’s Disease: A White-Box Approach

Yumiko Wiranto,
Devin R Setiawan,
Amber Watts
et al.

Abstract: ObjectiveThis study aimed to bridge the gap between the costliness and complexity of diagnosing Alzheimer’s disease by developing a scoring system with interpretable machine learning to predict the risk of Alzheimer’s using obtainable variables to promote accessibility and early detection.Participants and MethodsWe analyzed 713 participants with normal cognition or mild cognitive impairment from the Alzheimer’s Disease Neuroimaging Initiative. We integrated cognitive test scores from various domains, informant… Show more

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