The collagen matrix regulates the survival and function of pancreatic islets

Zhu, Yingying; Yang, Mei; Xu, Wanli; Zhang, Yun; Pan, Linlin; Wang, Lina; Wang, Furong; Lu, Yanting

doi:10.1007/s12020-023-03592-4

Cited by 3 publications

(1 citation statement)

References 94 publications

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“…Encapsulating islets with hydrogel mimicking the natural ECM is an effective strategy to promote vascularization of islet grafts [ 163 , 164 ]. As a major component of the ECM, collagen plays a key role in maintaining islet function [ 165 ]. Coculture of islets by pre-vascularized collagen hydrogel markedly improved islet revascularization after transplantation [ 166 , 167 ].…”

Section: Approaches To Improve Transplantation Efficacymentioning

confidence: 99%

Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy

Huan,

Li,

Luo

et al. 2024

Research

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Islet transplantation has now become a promising treatment for insulin-deficient diabetes mellitus. Compared to traditional diabetes treatments, cell therapy can restore endogenous insulin supplementation, but its large-scale clinical application is impeded by donor shortages, immune rejection, and unsuitable transplantation sites. To overcome these challenges, an increasing number of studies have attempted to transplant hydrogel-encapsulated islet cells to treat diabetes. This review mainly focuses on the strategy of hydrogel-encapsulated pancreatic islet cells for diabetic cell therapy, including different cell sources encapsulated in hydrogels, encapsulation methods, hydrogel types, and a series of accessorial manners to improve transplantation outcomes. In addition, the formation and application challenges as well as prospects are also presented.

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Section: Approaches To Improve Transplantation Efficacymentioning

confidence: 99%

Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy

Huan,

Li,

Luo

et al. 2024

Research

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Islet Transplantation: Current Limitations and Challenges for Successful Outcomes

Langlois,

Pinget,

Kessler

et al. 2024

Cells

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Islet transplantation is a promising approach for treating patients with unstable T1DM. However, it is confronted with numerous obstacles throughout the various stages of the transplantation procedure. Significant progress has been made over the last 25 years in understanding the mechanisms behind the loss of functional islet mass and in developing protective strategies. Nevertheless, at present, two to three pancreases are still needed to treat a single patient, which limits the maximal number of patients who can benefit from islet transplantation. Thus, this publication provides an overview of recent scientific findings on the various issues affecting islet transplantation. Specifically, we will focus on the understanding of the mechanisms involved and the strategies developed to alleviate these problems from the isolation stage to the post-transplantation phase. Finally, we hope that this review will highlight new avenues of action, enabling us to propose pancreatic islet transplantation to a maximum number of patients with T1DM.

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Human Acellular Collagen Matrices—Clinical Opportunities in Tissue Replacement

Verboket,

Henrich,

Janko

et al. 2024

IJMS

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The field of regenerative medicine is increasingly in need of effective and biocompatible materials for tissue engineering. Human acellular dermal matrix (hADM)-derived collagen matrices stand out as a particularly promising candidate. Their ability to preserve structural integrity, coupled with exceptional biocompatibility, positions them as a viable choice for tissue replacement. However, their clinical application has been largely confined to serving as scaffolds. This study aims to expand the horizon of clinical uses for collagen sheets by exploring the diverse cutting-edge clinical demands. This review illustrates the clinical utilizations of collagen sheets beyond traditional roles, such as covering skin defects or acting solely as scaffolds. In particular, the potential of Epiflex®, a commercially available and immediately clinically usable allogeneic membrane, will be evaluated. Collagen sheets have demonstrated efficacy in bone reconstruction, where they can substitute the induced Masquelet membrane in a single-stage procedure, proving to be clinically effective and safe. The application of these membranes allow the reconstruction of substantial tissue defects, without requiring extensive plastic reconstructive surgery. Additionally, they are found to be apt for addressing osteochondritis dissecans lesions and for ligament reconstruction in the carpus. The compelling clinical examples showcased in this study affirm that the applications of human ADM extend significantly beyond its initial use for skin defect treatments. hADM has proven to be highly successful and well-tolerated in managing various etiologies of bone and soft tissue defects, enhancing patient care outcomes. In particular, the application from the shelf reduces the need for additional surgery or donor site defects.

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The collagen matrix regulates the survival and function of pancreatic islets

Cited by 3 publications

References 94 publications

Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy

Hydrogel-Encapsulated Pancreatic Islet Cells as a Promising Strategy for Diabetic Cell Therapy

Islet Transplantation: Current Limitations and Challenges for Successful Outcomes

Human Acellular Collagen Matrices—Clinical Opportunities in Tissue Replacement

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