The colonized microbiota composition in the peritoneal fluid in women with endometriosis

Wen, Yan; Wu, Yahong; Chai, Xiaoshan; Wu, Xianqing

doi:10.1007/s00404-021-06338-7

Cited by 22 publications

(34 citation statements)

References 45 publications

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“…Further a study on human stool samples revealed the differences in the alpha and beta diversities and altered Firmicutes-to-Bacteroidetes ratio [ 22 ]. A more recent study reported the altered peritoneal microbiome in women with endometriosis [ 23 ]. Moreover, several studies including our previous work showed that gut microbial communities are altered in mice as well as women with endometriosis [ 21 , 24 , 25 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

“…Third, a study by Svensson et al carried out on human stool samples revealed high alpha (the microbial diversity of a single sample) and beta diversities (a measure of similarity or dissimilarity between two communities), as well as the Firmicutes-to-Bacteroidetes ratio [ 22 ] in control group ( n = 198) than the endometriosis patients ( n = 66) [ 22 ]. Fourth, the human peritoneal microbiome analysis revealed the abundance of Acidovorax, Devosia, Methylobacterium, Phascolarctobacterium , and Streptococcus in the peritoneal fluid of endometriosis patients than the matched controls [ 23 ], Fifth, in a mouse model of endometriosis in which endometrial fragments are injected into the intraperitoneal space, endometriosis was linked with alterations in the gut microbiome [ 24 ]. Finally, in our first study, we found that treatment with either broad-spectrum antibiotics or metronidazole after lesion initiation reduced lesion growth in a surgical model of endometriosis [ 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Gut microbiota and microbiota-derived metabolites promotes endometriosis

et al. 2023

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Endometriosis is a pathological condition of the female reproductive tract characterized by the existence of endometrium-like tissue at ectopic sites, affecting 10% of women between the age 15 and 49 in the USA. However, currently there is no reliable non-invasive method to detect the presence of endometriosis without surgery and many women find hormonal therapy and surgery as ineffective in avoiding the recurrences. There is a lack of knowledge on the etiology and the factors that contribute to the development of endometriosis. A growing body of recent evidence suggests an association between gut microbiota and endometriosis pathophysiology. However, the direct impact of microbiota and microbiota-derived metabolites on the endometriosis disease progression is largely unknown. To understand the causal role of gut microbiota and endometriosis, we have implemented a novel model using antibiotic-induced microbiota-depleted (MD) mice to investigate the endometriosis disease progression. Interestingly, we found that MD mice showed reduced endometriotic lesion growth and, the transplantation of gut microbiota by oral gavage of feces from mice with endometriosis rescued the endometriotic lesion growth. Additionally, using germ-free donor mice, we indicated that the uterine microbiota is dispensable for endometriotic lesion growth in mice. Furthermore, we showed that gut microbiota modulates immune cell populations in the peritoneum of lesions-bearing mice. Finally, we found a novel signature of microbiota-derived metabolites that were significantly altered in feces of mice with endometriosis. Finally, we found one the altered metabolite, quinic acid promoted the survival of endometriotic epithelial cells in vitro and lesion growth in vivo, suggesting the disease-promoting potential of microbiota-derived metabolites. In summary, these data suggest that gut microbiota and microbiota-derived metabolome contribute to lesion growth in mice, possibly through immune cell adaptations. Of translational significance, these findings will aid in designing non-invasive diagnostics using stool metabolites for endometriosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Gut microbiota and microbiota-derived metabolites promotes endometriosis

et al. 2023

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“…The majority of the clinical studies investigating endometriosis and microbiome changes were derived from Asia including Japan, China, Taiwan, Korea, and Turkey ( Table 3 , Supplementary Table S1 ) [ 21 , 108 , 109 , 110 , 111 , 112 , 113 , 114 , 115 , 116 , 117 , 118 ]. There were also some studies from the United States, Brazil, Sweden, and Canada [ 119 , 120 , 121 , 122 , 123 ].…”

Section: The Intricate Relationship Between the Female Reproductive T...mentioning

confidence: 99%

“…As such, it is certainly logical to investigate the changes in the peritoneal microbiome among endometriosis patients, given that the lesion may involve the peritoneum [ 110 , 116 , 128 ]. In 2022, Yuan et al reported that there was a total of 276 operational taxonomic units (OTUs) detected in peritoneal fluid collected from endometriosis patients (as compared to 211 OTUs in the control group); out of which, 120 of them were unique to endometriosis group [ 117 ]. At the genus level, there was a significantly higher abundance of Acidovorax ( p = 0.01), Devosia ( p = 0.03), Methylobacterium ( p = 0.03), Phascolarctobacterium ( p = 0.03), and Streptococcoccus ( p = 0.04) in endometriosis group than the control group.…”

Section: The Intricate Relationship Between the Female Reproductive T...mentioning

confidence: 99%

Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review

et al. 2023

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Endometriosis affects approximately 6 to 10% of reproductive-age women globally. Despite much effort invested, the pathogenesis that promotes the development, as well as the progression of this chronic inflammatory disease, is poorly understood. The imbalance in the microbiome or dysbiosis has been implicated in a variety of human diseases, especially the gut microbiome. In the case of endometriosis, emerging evidence suggests that there may be urogenital-gastrointestinal crosstalk that leads to the development of endometriosis. Researchers may now exploit important information from microbiome studies to design endometriosis treatment strategies and disease biomarkers with the use of advanced molecular technologies and increased computational capacity. Future studies into the functional profile of the microbiome would greatly assist in the development of microbiome-based therapies to alleviate endometriosis symptoms and improve the quality of life of women suffering from endometriosis.

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“…The mechanisms underlying these medical interventions that affected the local microbiota in women with endometriosis remain unelucidated. Regarding other bacterial genera/species, the consequences are quite inconsistent among the studies [22][23][24][25][26][27][28]. These discrepancies are likely to result from the conditions for examinations such as types of local disinfectants, sampling device, and route.…”

Section: Microbiota In Reproductive Tract In Endometriosis and Cementioning

confidence: 99%

Endometriosis as an Infectious Disease: Association with Chronic Endometritis

Kitaya¹,

Mihara²,

Mihara³

2023

Clin. Exp. Obstet. Gynecol.

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Objectives: Recent studies focus on immunological, infectious, and inflammatory aspects of endometriosis. Meanwhile, chronic endometritis (CE) is an immunological, infectious, and inflammatory disorder of the eutopic endometrium with unusual stromal plasmacyte infiltration. Mechanism: In this review article, we aimed to gain a better understanding of the relationships between endometriosis and CE. Findings in Brief: Accumulating evidence supports the idea that CE is associated with infertility of unknown etiology, repeated implantation failure in an in vitro fertilization-embryo transfer program, recurrent pregnancy loss, as well as several perinatal/neonatal complications. Endometrial biopsy/histopathologic examinations and/or hysteroscopy are required to make a definitive diagnosis of CE. Conclusions: While endometriosis has been long considered a cause of infertility, CE is also an emerging issue that may reduce fecundity in women of reproductive age. Endometriosis and CE share characteristics of endometrial proliferative nature. The potential relationships between these two diseases of the uterine lining warrant future studies.

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The colonized microbiota composition in the peritoneal fluid in women with endometriosis

Cited by 22 publications

References 45 publications

Gut microbiota and microbiota-derived metabolites promotes endometriosis

Gut microbiota and microbiota-derived metabolites promotes endometriosis

Current Updates on the Role of Microbiome in Endometriosis: A Narrative Review

Endometriosis as an Infectious Disease: Association with Chronic Endometritis

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