The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition

Miraglia, Francesca; Pappalettera, Chiara; Guglielmi, Valeria; Cacciotti, Alessia; Manenti, Rosa; Judica, Elda; Vecchio, Fabrizio; Rossini, Paolo Maria

doi:10.1007/s11357-023-00733-5

Cited by 5 publications

(6 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The LFP data were band-pass filtered with a finite impulse filter (FIR) applied to extract data in the frequency range from 0.2 to 47 Hz. 51 , 52 LFP continuous data were segmented in 2 sec length epochs and trials with artefact activity or aberrant waveforms (i.e. movements and environmental artefacts) were removed by an expert data visual inspection.…”

Section: Methodsmentioning

confidence: 99%

Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice

Miraglia,

Pappalettera,

Barbati

et al. 2024

Brain Communications

Self Cite

View full text Add to dashboard Cite

Stroke is one of the leading causes of disability worldwide. There are many different rehabilitation approaches aimed at improving clinical outcomes for stroke survivors. One of the latest therapeutic techniques is the non-invasive brain stimulation. Among non-invasive brain stimulation, transcranial direct current stimulation has shown promising results in enhancing motor and cognitive recovery both in animal models of stroke and stroke survivors. In this framework, one of the most innovative methods is the bihemispheric transcranial direct current stimulation that simultaneously increases excitability in one hemisphere and decreases excitability in the contralateral one. As bihemispheric transcranial direct current stimulation can create a more balanced modulation of brain activity, this approach may be particularly useful in counteracting imbalanced brain activity, such as in stroke. Given these premises, the aim of the current study has been to explore the recovery after stroke in mice that underwent a bihemispheric transcranial direct current stimulation treatment, by recording their electric brain activity with local field potential and by measuring behavioural outcomes of Grip Strength test. An innovative parameter that explores the complexity of signals, namely the Entropy, recently adopted to describe brain activity in physiopathological states, was evaluated to analyse local field potential data. Results showed that stroke mice had higher values of Entropy compared to healthy mice, indicating an increase in brain complexity and signal disorder due to the stroke. Additionally, the bihemispheric transcranial direct current stimulation reduced Entropy in both healthy and stroke mice compared to sham stimulated mice, with a greater effect in stroke mice. Moreover, correlation analysis showed a negative correlation between Entropy and Grip Strength values, indicating that higher Entropy values resulted in lower Grip Strength engagement. Concluding, the current evidence suggests that the Entropy index of brain complexity characterizes stroke pathology and recovery. Together with this, bihemispheric transcranial direct current stimulation can modulate brain rhythms in animal models of stroke, providing potentially new avenues for rehabilitation in humans.

show abstract

Section: Methodsmentioning

confidence: 99%

Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice

Miraglia,

Pappalettera,

Barbati

et al. 2024

Brain Communications

Self Cite

View full text Add to dashboard Cite

show abstract

“…Functional connectivity refers to the temporal correlation of neural activity between different brain regions, which reflects the coordination and integration of neural networks. Disruptions in functional connectivity with aging [376] have been implicated in various cognitive impairments and neurological disorders [377][378][379][380][381][382][383][384][385][386][387][388]. Brain connectivity, essential for efficient cognitive function, can be influenced by dietary factors [389][390][391].…”

Section: Methionine-rich Diet Hyperhomocysteinemia and Altered Functi...mentioning

confidence: 99%

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

Ungvari,

Gulej,

Csik

et al. 2023

Nutrients

View full text Add to dashboard Cite

As aging societies in the western world face a growing prevalence of vascular cognitive impairment and Alzheimer’s disease (AD), understanding their underlying causes and associated risk factors becomes increasingly critical. A salient concern in the western dietary context is the high consumption of methionine-rich foods such as red meat. The present review delves into the impact of this methionine-heavy diet and the resultant hyperhomocysteinemia on accelerated cerebrovascular and brain aging, emphasizing their potential roles in cognitive impairment. Through a comprehensive exploration of existing evidence, a link between high methionine intake and hyperhomocysteinemia and oxidative stress, mitochondrial dysfunction, inflammation, and accelerated epigenetic aging is drawn. Moreover, the microvascular determinants of cognitive deterioration, including endothelial dysfunction, reduced cerebral blood flow, microvascular rarefaction, impaired neurovascular coupling, and blood–brain barrier (BBB) disruption, are explored. The mechanisms by which excessive methionine consumption and hyperhomocysteinemia might drive cerebromicrovascular and brain aging processes are elucidated. By presenting an intricate understanding of the relationships among methionine-rich diets, hyperhomocysteinemia, cerebrovascular and brain aging, and cognitive impairment, avenues for future research and potential therapeutic interventions are suggested.

show abstract

“…Despite these limitations, a consensus seems to hold that among various graph theoretical measures, the functional brain network of patients with AD exhibits altered SW compared to healthy controls ( 35 – 43 ). Specifically, when these networks are constructed from resting-state recordings under eyes-closed [EC] conditions, patients with AD tend to exhibit reduced SW in the delta and theta frequency bands ( 35 – 37 , 41 , 42 ), along with the beta band ( 36 , 40 , 41 ), relative to healthy individuals. In contrast, patients with AD showed elevated SW within the alpha band ( 36 , 41 , 42 ).…”

Section: Introductionmentioning

confidence: 99%

“…Given the progressive impairment in the reactivity of alpha waves, or more specifically, their suppression in response to eye-opening, observed in patients with AD ( 23 ), an exploration of the variances in the SW properties of functional brain networks between EC and eyes-open (EO) states in patients with AD might be insightful. However, this issue has only been addressed by Miraglia et al ( 35 ). Miraglia et al reported analogous patterns of SW changes between the EC and EO states in patients with AD and healthy controls.…”

Section: Introductionmentioning

confidence: 99%

“…Intriguingly, healthy controls also exhibited decreased SW in the EC state compared to that in the EO state within the lower alpha band (8–10.5 Hz); however, this reactivity was absent in the AD group. Regrettably, Miraglia et al ( 35 ) did not examine the interaction effect between disease condition (AD vs. healthy controls) and state (i.e., EC vs. EO) on SW. Whether state-dependent alterations in SW differ between patients with AD and healthy controls remains unclear.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Eyes-state-dependent alterations of magnetoencephalographic connectivity associated with delayed recall in Alzheimer’s disease via graph theory approach

Yuasa,

Hirosawa,

Soma

et al. 2023

Front. Psychiatry

View full text Add to dashboard Cite

IntroductionAlzheimer’s disease (AD) is a neurodegenerative disorder characterized by memory impairment and cognitive decline. Electroencephalography (EEG) and magnetoencephalography (MEG) studies using graph theory show altered “Small-Worldness (SW)” properties in AD. This study aimed to investigate whether eye-state-dependent alterations in SW differ between patients with AD and healthy controls, considering the symptoms of AD.MethodsNineteen patients with AD and 24 healthy controls underwent MEG under different conditions (eyes-open [EO] and eyes-closed [EC]) and the Wechsler Memory Scale-Revised (WMS-R) with delayed recall. After the signal sources were mapped onto the Desikan–Killiany brain atlas, the statistical connectivity of five frequency bands (delta, theta, alpha, beta, and gamma) was calculated using the phase lag index (PLI), and binary graphs for each frequency band were constructed based on the PLI. Next, we measured SW as a graph metric and evaluated three points: the impact of AD and experimental conditions on SW, the association between SW and delayed recall, and changes in SW across experimental conditions correlated with delayed recall.ResultsSW in the gamma band was significantly lower in patients with AD (z = −2.16, p = 0.031), but the experimental conditions did not exhibit a significant effect in any frequency band. Next, in the AD group, higher scores on delayed recall correlated with diminished SW across delta, alpha, and beta bands in the EO condition. Finally, delayed recall scores significantly predicted relative differences in the SW group in the alpha band (t = −2.98, p = 0.009).DiscussionGiven that network studies could corroborate the results of previous power spectrum studies, our findings contribute to a multifaceted understanding of functional brain networks in AD, emphasizing that the SW properties of these networks change according to disease status, cognitive function, and experimental conditions.

show abstract

The combination of hyperventilation test and graph theory parameters to characterize EEG changes in mild cognitive impairment (MCI) condition

Cited by 5 publications

References 59 publications

Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice

Brain complexity in stroke recovery after bihemispheric transcranial direct current stimulation in mice

The Role of Methionine-Rich Diet in Unhealthy Cerebrovascular and Brain Aging: Mechanisms and Implications for Cognitive Impairment

Eyes-state-dependent alterations of magnetoencephalographic connectivity associated with delayed recall in Alzheimer’s disease via graph theory approach

Contact Info

Product

Resources

About