The Common C49620T Polymorphism in the Sulfonylurea Receptor Gene SUR1 (ABCC8) in Patients with Gestational Diabetes and Subsequent Glucose Metabolism Abnormalities

Abstract

Aim. The aim of this study is to investigate the relationship between the common C49620T polymorphism in the sulfonylurea receptor (SUR1) gene and glucose metabolism, β-cell secretory function and insulin resistance in women with a history of gestational diabetes (GDM). Material and Methods. Study group included 199 women, diagnosed GDM within the last 5–12 years and control group of comparable 50 women in whom GDM was excluded during pregnancy. Blood glucose and insulin levels were measured during oral glucose tolerance test. Indices of insulin resistance (HOMA-IR) and β-cell function (HOMA %B) were calculated. In all patients, the C49620T polymorphism in intron 15 of the SUR1 gene was determined. Results. The distribution of the studied polymorphism in the two groups did not differ from each other (χ 2 = 0.34, P = 0.8425). No association between the distribution of polymorphisms and coexisting glucose metabolism disorders (χ 2 = 7,13, P = 0, 3043) was found. No association was also observed between the polymorphism and HOMA %B or HOMA-IR. Conclusions. The polymorphism C49620T in the SUR1 gene is not associated with insulin resistance and/or insulin secretion in women with a history of GDM and does not affect the development of GDM, or the development of glucose intolerance in the studied population.

Possible association between ABCC8 C49620T polymorphism and type 2 diabetes in a Nigerian population

“…Our study showed predominance of the T allele over the C allele with a significant risk ( p < 0.05) of T2D. This is in contrast to findings from other regions across the globe where the wild type C allele is usually predominant in the population [ 23 , 24 ]. The homozygote mutant TT genotype was more frequent than the homozygote wild type CC genotype while the heterozygote CT was the least frequent.…”

HFE Gene Mutation Associated with the Severity of Gestational Diabetes Mellitus in Belarusian Women

“…Number of human genes was investigated dealing with GDM: HLA, SUR1 (sufonylurea receptor gene), GCK (glucokinase gene), TCF7L2 (transcription factor 7-like 2 gene), HFE (hemochromatosis gene) and others with contradicting results [5][6][7][8][9][10].…”