The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population

Šplíchal, Zbyněk; Vašků, Julie Bienertová; Novák, Jan; Zlámal, Filip; Tomandl, Josef; Tomandlová, Marie; Forejt, Martin; Havlenova, Sona; Jackowská, Aneta; Vašků, Anna

doi:10.1179/1476830513y.0000000100

Cited by 20 publications

(25 citation statements)

References 22 publications

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“…In these studies the polymorphism Val109Asp was the most frequently analyzed. The results of these studies demonstrated an association between the TT genotype and a lower energy-supplemented diet and the AA genotype and higher energy content of meals (29). In other studies, no relationship was confirmed between the analyzed polymorphism and the development of osteoporosis.…”

Section: Discussionmentioning

confidence: 94%

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Omentin Polymorphism and its Relations to Bone Mineral Density in Women

Boroń

Czerny

Bartkowiak‐Wieczorek

et al. 2015

Archives of Medical Research

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Section: Discussionmentioning

confidence: 94%

“…There have been many studies that explore the relationship between gene polymorphism of omentin and occurrence of some diseases such as eating disorders and obesity (29), diabetes (30), heart disease (31), acne (32), and bowel disease (30). In these studies the polymorphism Val109Asp was the most frequently analyzed.…”

Section: Discussionmentioning

confidence: 99%

Omentin Polymorphism and its Relations to Bone Mineral Density in Women

Boroń

Czerny

Bartkowiak‐Wieczorek

et al. 2015

Archives of Medical Research

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“…В настоящее время исследований по оценке распределений вариантов полиморфизма Val109Asp гена оментина в различных азиатских и европейских популяциях немного. Тем не менее, по имеющимся немногочисленным литературным данным, частота встречаемости минорного аллеля Val маркера Val109Asp гена оментина у иранцев составляет 0,18 [16], у турков -0,22 [17], у чехов -0,30 [18], у американцев -0,31 [12]. В кыргызской популяции частота встречаемости минорного аллеля Val составила 0,26.…”

Section: Discussionunclassified

“…В доступной научной литературе имеются единичные исследования, касающиеся ассоциативных связей полиморфного локуса Val109Asp гена оментина с различными компонентами МС, в том числе и с АО. В 2015 г. опубликована работа, показавшая ассоциацию локуса Val109Asp гена оментина с развитием АО у чехов [18]. При исследовании чешской популяции пациенты с ожирением и без ожирения по частоте встречаемости генотипов и аллелей полиморфного маркера Val109Asp гена оментина существенно не отличались.…”

Section: Discussionunclassified

“…У чехов при изучении влияния вариантов полиморфного маркера Val109Asp на уровень оментина самый низкий уровень оментина в крови (409,7±169,1 мкг/л) соответствовал группе лиц с генотипом Val109Val, а самый высокий уровень оментина (475,7±153,7 мкг/л)группе лиц с генотипом Asp109Asp. Однако эти различия не были достоверными [18].…”

Section: Discussionunclassified

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A polymorphic marker Val109Asp in the omentin gene are associated with abdominal obesity in the Kyrgyz population

Толоновна¹,

Талайбековна²,

Абилгазыевна³

et al. 2016

Probl Endokrinol (Mosk)

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Aim — in this study, we investigated whether polymorphisms Val109Asp in the omentin gene are associated with abdominal obesity in the Kyrgyz population.Material and methods. We genotyped 297 nonrelated adults Kyrgyz individuals. 127 patients (male — 46, female — 81, average age — 53±7,0) with abdominal obesity (elevated waist circumferences ≥102 cm for male subjects and ≥ 88 cm for female) and 170 non-obese control subjects (male — 107, female — 63, average age 51±9). Val109Asp polymorphisms analysis in the omentin gene were performed by PCR-RFLP method.Results. There were significant differences in genotype distributions of rs2274907 between the obese and control cohorts (p=0.01). Frequencies of Asp109Asp, Val109Asp and Val109Val genotypes among patients with abdominal obesity were 48, 40 and 12%, respectively, that differed from those among controls (Asp109Asp — 53%, Val109Aspl — 43% and Val109Val — 4%); there was significant difference in genotype frequencies between two groups (χ²=6,29; p=0,043). Homozygous genotype Val109Val was more frequent in the obese than non-obese group. The genotype Val109Val of omentin gene is associated with a high risk of developing abdominal obesity in the Kyrgyz population (OR=3,12; 95% CI 1,23—7,90). Homozygous genotype Asp109Asp, reduces the risk of developing abdominal obesity (OR=0,82; 95% CI 0,53—1,30). The allelic variants of the polymorphisms Val109Asp in the omentin gene were not found to be associated with abdominal obesity.Conclusion. There is significant association between Val109Asp polymorphism in omentin gene and abdominal obesity in the Kyrgyz Population. An increased risk of abdominal obesity associated with homozygous genotype — Val109Val in omentin gene.

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Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients

et al. 2015

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Previous studies have suggested that psoriasis is associated with individuals who are overweight or obese. Omentin is a recently discovered adipokine that is involved in chronic inflammatory processes. This study evaluated the relationship between omentin and psoriasis, focusing on omentin-1 serum levels, skin expression of omentin-1, and omentin-1 gene polymorphism (rs2274907; Val109Asp). Levels of omentin-1 in serum samples from 44 patients with psoriasis and 38 healthy controls were analyzed by enzyme-linked immunosorbent assay. The expressions of omentin-1 were measured by immunohistochemistry in 3 psoriasis affected skins and 3 normal skins. The rs2274907 variant was typed using a SNaPshot assay in 354 cases and 214 controls. We found significantly lower serum levels of omentin-1 in psoriasis patients compared with healthy controls (p < 0.001) with an inverse correlation with the Psoriasis Area and Severity Index (p < 0.01). The comparison of genotype and allele distribution revealed no significant difference in genotype frequency between psoriasis patients and controls. Therefore, omentin-1 may have a role in the pathogenesis of psoriasis and might be a potential biological marker for psoriasis severity.

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The common polymorphism Val109Asp in the omentin gene is associated with daily energy intake in the Central-European population

Abstract: This is, so far, the first study to investigate the polymorphisms in the omentin gene in a large population cohort of obese and non-obese individuals. Based on our results, the rs2274907 polymorphism is associated with the daily energy intake as well as daily intake of fat and protein.

Cited by 20 publications

References 22 publications

Omentin Polymorphism and its Relations to Bone Mineral Density in Women

Omentin Polymorphism and its Relations to Bone Mineral Density in Women

A polymorphic marker Val109Asp in the omentin gene are associated with abdominal obesity in the Kyrgyz population

Omentin-1 plasma levels and omentin-1 expression are decreased in psoriatic lesions of psoriasis patients

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