The Comparative Myocardial Protection by Propofol and Isoflurane in an In Vivo Model of Ischemia Reperfusion

Abstract

Only ISO improved the recovery of the ischemic myocardium during reperfusion. The effects of PRP were global in nature and involved compensatory hypercontractile state in nonischemic regions of the myocardium. Implication. PRP and ISO protect the heart against an ischemic injury, but only ISO preserves the function of the myocardium at the ischemic region. The survival rate of the PRP-treated group versus the ISO-treated group supports the claim that PRP has smaller contribution to recovery from myocardial ischemia.

The immune response to anesthesia: Part 2 sedatives, opioids, and injectable anesthetic agents

“…Similarly, isoflurane globally improved the recovery from cardiac ischemia compared to propofol in a rabbit cardiopulmonary by‐pass model (Asgeri et al. ).…”

“…In a rabbit cardiopulmonary by‐pass model, propofol reduced the effects of cardiac ischemia‐reperfusion injury, but was not as effective as isoflurane (Asgeri et al. ). In rats, propofol significantly reduced subsequent oxidative injury in a renal ischemia‐reperfusion injury model (Dogan et al.…”

Effect of trapidil in myocardial ischemia-reperfusion injury in rabbit

“…Left thoracotomy was performed and the left main artery was exposed according to the method described by Asgeri et al . [8910] A silk thread was passed around the left anterior descending coronary artery (LAD). The end of the tie was threaded through a small vinyl tube to form a snare.…”

Documento de posicionamiento: uso de sedación inhalada en el paciente críticamente enfermo

“…La mejora de la cardiaca por isoflurano puede involucrar diferentes mecanismos ya que es eficaz para mejorar la contractilidad miocárdica en la región isquémica durante la fase de reperfusión, sin efectos significativos sobre la función regional. 72,73…”