The comparison of zinc, copper and iron levels in serum, aorta and left internal mammarian artery tissues in coronary by-pass graft surgery patients

Karış, Denizhan; Tarhan, Duygu; Boyacıoğlu, Kamil; Köksal, Cengiz; Ercan, Meltem

doi:10.1016/j.jtemb.2018.10.003

Cited by 10 publications

(5 citation statements)

References 25 publications

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“…84,95 Zinc has been alloyed with Mg, Ca, and Sr (and other elements) to create biometals with the objective to tailor the mechanical and degradation properties. 24,95,109,110 For instance, Mg−Zn−Ca alloys (with the nominal composition Mg−4Zn−0.1Ca) were developed with promising values for the tensile strength (380 MPa), endurance limit (120 MPa), and optimal values of low strength. 92 Additionally, studies of quaternary Mg−Ca−Mn−Zn alloys having enhanced corrosion resistance compared to binary Mg−Ca alloys have been reported.…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

“…84,112 More importantly, an antiatherogenic effect due to its membrane-stabilizing abilities was reported. 109 Unlike the degradation mechanism of the Mg-based alloys, hydrogen gas was not generated within the process. However, during the corrosion period three layers were formed composed of calcium/phosphorus, zinc oxide, and zinc carbonate; the degradation products were similar to those of the Mg-based alloys.…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

“…Zinc (Zn) alloys have recently been explored as an alternative to traditional stent materials. Zn stent reabsorption is generally defined as desirable; however, experimental alloys have yet to meet the elongation (18–20%) and tensile strength (300 MPa) characteristics needed to compare favorably with the previously mentioned designs. , Zinc has been alloyed with Mg, Ca, and Sr (and other elements) to create biometals with the objective to tailor the mechanical and degradation properties. ,,, For instance, Mg–Zn–Ca alloys (with the nominal composition Mg–4Zn–0.1Ca) were developed with promising values for the tensile strength (380 MPa), endurance limit (120 MPa), and optimal values of low strength . Additionally, studies of quaternary Mg–Ca–Mn–Zn alloys having enhanced corrosion resistance compared to binary Mg–Ca alloys have been reported .…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

“…Regarding Zn biocompatibility and incorporation into human cell regulation, zinc participates in many distinct physiological pathways, including genetic expression and regulation, DNA replication, and RNA transcription, as well as in DNA repair. , More importantly, an antiatherogenic effect due to its membrane-stabilizing abilities was reported . Unlike the degradation mechanism of the Mg-based alloys, hydrogen gas was not generated within the process.…”

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

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Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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Globally, the leading causes of natural death are attributed to coronary heart disease and type 1 and type 2 diabetes. High blood pressure levels, high cholesterol levels, smoking, and poor eating habits lead to the agglomeration of plaque in the arteries, reducing the blood flow. The implantation of devices used to unclog vessels, known as stents, sometimes results in a lack of irrigation due to the excessive proliferation of endothelial tissue within the blood vessels and is known as restenosis. The use of drug-eluting stents (DESs) to deliver antiproliferative drugs has led to the development of different encapsulation techniques. However, due to the potency of the drugs used in the initial stent designs, a chronic inflammatory reaction of the arterial wall known as thrombosis can cause a myocardial infarction (MI). One of the most promising drugs to reduce this risk is everolimus, which can be encapsulated in lipid systems for controlled release directly into the artery. This review aims to discuss the current status of stent design, fabrication, and functionalization. Variables such as the mechanical properties, metals and their alloys, drug encapsulation and controlled elution, and stent degradation are also addressed. Additionally, this review covers the use of polymeric surface coatings on stents and the recent advances in layer-by-layer coating and drug delivery. The advances in nanoencapsulation techniques such as liposomes and micro- and nanoemulsions and their functionalization in bioresorbable, drug-eluting stents are also highlighted.

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Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

Section: Current Status Of Drug-eluting Stentsmentioning

confidence: 99%

See 2 more Smart Citations

Drug-Eluting, Bioresorbable Cardiovascular Stents─Challenges and Perspectives

Vallejo-Zamora

Vega-Cantú

Rodrı́guez

et al. 2022

ACS Appl. Bio Mater.

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“…However, disturbances in trace element homeostasis, or the accumulation of toxic elements may affect physiological processes, and also contribute to the development of metabolic diseases. Previous studies have focused on blood serum, aortic samples, coronary artery samples, carotid artery samples [49], and liver biopsy samples [50]. To our knowledge, this is the first study to include autopsy tissues from different brain regions and the liver in groups with atherosclerosis and hepatic steatosis.…”

Section: Introductionmentioning

confidence: 99%

Linking Metallic Micronutrients and Toxic Xenobiotics to Atherosclerosis and Fatty Liver Disease—Postmortem ICP-MS Analysis of Selected Human Tissues

et al. 2023

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Dyslipidaemia is a disorder of the lipid metabolism, caused mainly by poor eating habits. The most severe consequence of an inappropriate diet is the development of atherosclerosis and hepatic steatosis. It is generally believed that a change in nutrition, and increased physical activity can eliminate these health problems. The contemporary research and therapies used to treat dyslipidemia mainly focus on lowering the triglyceride and cholesterol levels. However, disturbances in trace element homeostasis or the accumulation of toxic elements can also affect physiological processes, and be involved in the development of metabolically mediated diseases. The present study aimed to determine the mineral profiles of liver and brain tissues collected at autopsy (n = 39) in groups of people with hepatic steatosis (n = 5), atherosclerosis (n = 9), hepatic steatosis, and atherosclerosis (n = 16), and others without the selected disorders (n = 9). Concentrations of 51 elements were analysed via inductively coupled plasma mass spectrometry (ICP-MS) after the initial wet mineralisation of the samples with nitric acid. The results obtained allow us to conclude that the hepatic steatosis group suffers from a deficiency of important trace elements, such as copper, zinc, and molybdenum (p < 0.05), whereas the group with atherosclerosis is characterised by elevated levels of cadmium in the liver tissue (p = 0.01). Analysing the mean values of the element concentrations measured in 11 brain areas, statistically significant higher levels of calcium and copper (p < 0.001) were found in the atherosclerosis group, compared to the hepatic steatosis group, confirming the involvement of these elements in the pathogenesis of atherosclerosis. In addition, an accumulation of cadmium, lead, titanium, and strontium in the brain tissue was observed in the atherosclerosis group. While the accumulation of individual elements differs in different parts of the brain, the differences in the cadmium content (p < 0.05) between the study groups apply to the whole brain, except for the nucleus accumbens septi area, where a statistically significant titanium accumulation occurs in the atherosclerosis and steatosis groups, compared to the others (p < 0.05). In addition, the disruption of elemental homeostasis in the brain of a single case with bipolar disorder, and a case with hip replacement was observed. Our results confirm the involvement of chemical elements in the pathogenesis of selected metabolic diseases, and the need for further studies in larger populations.

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