The Complementary Role of Selenium and Its Botanical Combinations in Regenerative Therapy

Abstract

Selenium (Se) is an essential element for animals. It mainly occurs in two forms; inorganic and organic. It was discovered by Berzelius in 1817 and its role as a micronutrient for the animal's health remained unknown till 1957. It has many health-beneficial effects and acts as an antioxidant, anti-inflammatory, antiviral, antimicrobial, and immune modulator. It is an integral part of many proteins and acts as a cofactor. Its oxidizing property is due to Se-dependent enzymes which maintain homeostasis. Besides these, it also alleviates heat stress, enhances the activity of reproductive organs, and heals histopathological changes induced by toxicants. Additionally, it also has a role in degenerative disorders and regulates wound healing and angiogenesis. In this chapter, the therapeutic potential of Se, its mechanism of action, its combination with botanicals, and regenerative therapy with Se are discussed.