The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins

Kalinowski, Jörn; Bathe, Brigitte; Bartels, Daniela; Bischoff, Nicole; Bott, Michael; Burkovski, Andreas; Dusch, Nicole; Eggeling, Lothar; Eikmanns, Bernhard J.; Gaigalat, Lars; Goesmann, Alexander; Hartmann, Michael; Huthmacher, Klaus; Krämer, Reinhard; Linke, Burkhard; McHardy, Alice C.; Meyer, Patrick; Möckel, Bettina; Pfefferle, Walter; Pühler, Alfred; Rey, Daniel A.; Rückert, Christian; Rupp, Oliver; Sahm, Hermann; Wendisch, Volker F.; Wiegräbe, Iris; Tauch, Andreas

doi:10.1016/s0168-1656(03)00154-8

Cited by 828 publications

(706 citation statements)

References 101 publications

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“…Найвищий рівень накопи÷ення лізину (коефіöієнт конверсії глюкози складає 30-40%) ìають ауксотрофи за гоìосериноì або лейöиноì [7,16,17].…”

Section: ðåгóлювàння òà шляхè Iнòåнñèфiêàöiї бIоñèнòåзó лIзèнóunclassified

“…Óсі гени корі-небактерій, що кодують öі ферìенти, ізольовано та секвеновано [6,7,8,17]. Для кожного гена визна÷ені його ìісöе і функöія у ìетаболі÷ноìу шляху та у÷асть у транспортуванні лізину [10,11,12] [13][14][15][16] .…”

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“…Êонтроль біосинтезу лізину забезпе÷ується за принöипоì зворотного зв'язку на рівні генів [16,17], які відповідають за синтез відповідних ферìентів (репресія) і на рівні саìих ферìентів, які в результаті над-лишку аìінокислот, що утворюються, ìожуть зìінювати свою активність (ретроінгібування) [2,18]. Даний ìеханізì контролю виклю÷ав переви-робниöтво аìінокислот, а також перешкоджає їх виділенню з клітин у навколишнє середовище [7,16,19,20].…”

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Regulation and Intensification Ways of Lysine Biosynthesis

Андріяш¹,

Заболотна²,

Shulga³

2012

Microbiology&Biotechnology

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Section: ðåгóлювàння òà шляхè Iнòåнñèфiêàöiї бIоñèнòåзó лIзèнóunclassified

unclassified

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Regulation and Intensification Ways of Lysine Biosynthesis

Андріяш¹,

Заболотна²,

Shulga³

2012

Microbiology&Biotechnology

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“…A further milestone towards systems level understanding was the sequencing of the C. glutamicum ATCC 13032 genome by at least three different biotechnological companies (BASF, Degussa, and Kyowa Hakko). The circular genome comprises about 3000 genes with a total size of 3.3 kb [45][46][47]. Subsequent annotation has helped greatly in elucidating the genetic repertoire.…”

Section: Genome Sequencing and Metabolic Network Reconstructionmentioning

confidence: 99%

“…In light of the established fermentation on cheap substrates [5], its known genome sequence [47] and the availability of genetic engineering tools C. glutamicum is regarded as key candidate to develop production strain for various other products. In addition to the above-mentioned traditional products, C. glutamicum has been recently engineered to accumulate a great variety of different compounds (Table 3) Due to impressive work in recent years, C. glutamicum is applicable to produce efficiently amino acids, organic acids, diamines, or biofuels, and the coming years will surely see a further broadening of its potential.…”

Section: Towards Novel Productsmentioning

confidence: 99%

Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum

Wittmann

2010

Biosystems Engineering I

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The Gram-positive soil bacterium Corynebacterium glutamicum was discovered as a natural overproducer of glutamate about 50 years ago. Linked to the steadily increasing economical importance of this microorganism for production of glutamate and other amino acids, the quest for efficient production strains has been an intense area of research during the past few decades. Efficient production strains were created by applying classical mutagenesis and selection and especially metabolic engineering strategies with the advent of recombinant DNA technology. Hereby experimental and computational approaches have provided fascinating insights into the metabolism of this microorganism and directed strain engineering. Today, C. glutamicum is applied to the industrial production of more than 2 million tons of amino acids per year. The huge achievements in recent years, including the sequencing of the complete genome and efficient post genomic approaches, now provide the basis for a new, fascinating era of research -analysis of metabolic and regulatory properties of C. glutamicum on a global scale towards novel and superior bioprocesses.

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Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics

Wasinger

2005

Methods of Biochemical Analysis

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The complete Corynebacterium glutamicum ATCC 13032 genome sequence and its impact on the production of l-aspartate-derived amino acids and vitamins

Cited by 828 publications

References 101 publications

Regulation and Intensification Ways of Lysine Biosynthesis

Regulation and Intensification Ways of Lysine Biosynthesis

Analysis and Engineering of Metabolic Pathway Fluxes in Corynebacterium glutamicum

Holistic Biology of Microorganisms: Genomics, Transcriptomics, and Proteomics

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