The Complex Roadmap to Infectious Disease Innovation: The Intersection of Bugs, Drugs, and Special Populations

Nicol, Melanie R.; Cicali, Emily J.; Seo, Shirley; Rao, Gauri G.

doi:10.1002/cpt.2208

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…As highlighted in the April 2021 issue of CPT on therapeutic innovations in infectious diseases, 10 there is now clear evidence and increasing awareness of the critical importance of clinical pharmacology considerations and a MIDD approach in the development and rational use of anti‐infectives, including and beyond coronavirus disease 2019 (COVID‐19). Garcia et al .…”

Section: Midd In Anti‐infective Development: a Case For Integrating S...mentioning

confidence: 99%

Model‐Informed Drug Development: Connecting the Dots With a Totality of Evidence Mindset to Advance Therapeutics

Venkatakrishnan

Graaf

2021

Clin Pharma and Therapeutics

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The Merriam-Webster dictionary offers the essential meaning of a model as "a usually small copy of something," or "a set of ideas and numbers that describe the past, present, or future state of something." Model-informed drug development (MIDD) involves the strategic creation and integration of mathematical models for knowledge management, predictions, and decision making in pharmaceutical research and development. These models can "connect the dots" across various inputs related to drug properties, disease biology, patient characteristics and trial designs, transforming data to knowledge, enhancing efficiency in drug discovery and development, and maximizing therapeutic potential. This issue of Clinical Pharmacology and Therapeutics (CPT) includes Original Research Articles, Reviews, and Perspectives illustrating recent advances in established and emerging areas of MIDD, highlighting opportunities for interdisciplinary and cross-sector collaboration for enhancing impact.

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Section: Midd In Anti‐infective Development: a Case For Integrating S...mentioning

confidence: 99%

Model‐Informed Drug Development: Connecting the Dots With a Totality of Evidence Mindset to Advance Therapeutics

Venkatakrishnan

Graaf

2021

Clin Pharma and Therapeutics

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“…Furthermore, contributions for themed issues are no longer by invitation only and open calls for papers are now being issued. Six themed issues have been published using this new format in the last 2 years, 3–8 and 3 are scheduled for publication in 2022 ( Table 1 ). Submissions for the “Transporter” theme (scheduled for publication in September 2022) are still being accepted.…”

Section: Figurementioning

confidence: 99%

Themes in Clinical Pharmacology and Therapeutics

Graaf

Gerding

2021

Clin Pharma and Therapeutics

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The Complex Roadmap to Infectious Disease Innovation: The Intersection of Bugs, Drugs, and Special Populations

Cited by 2 publications

References 18 publications

Model‐Informed Drug Development: Connecting the Dots With a Totality of Evidence Mindset to Advance Therapeutics

Model‐Informed Drug Development: Connecting the Dots With a Totality of Evidence Mindset to Advance Therapeutics

Themes in Clinical Pharmacology and Therapeutics

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