The Composite Immune Risk Score predicts overall survival after allogeneic hematopoietic stem cell transplantation: A retrospective analysis of 1838 cases

Abstract

There has been little consensus on how to quantitatively assess immune reconstitution after hematopoietic stem cell transplantation (HSCT) as part of the standard of care. We retrospectively analyzed 11 150 post‐transplant immune profiles of 1945 patients who underwent HSCT between 2012 and 2020. 1838 (94.5%) of the cases were allogeneic HSCT. Using the training set of patients (n = 729), we identified a composite immune signature (integrating neutrophil, total lymphocyte, natural killer, total T, CD4+ T, and B cell counts in the peripheral blood) during days 91–180 after allogeneic HSCT that was predictive of early mortality and moreover simplified it into a formula for a Composite Immune Risk Score. When we verified the Composite Immune Risk Score in the validation (n = 284) and test (n = 391) sets of patients, a high score value was found to be associated with hazard ratios (HR) of 3.64 (95% C.I. 1.55–8.51; p = .0014) and 2.44 (95% C.I., 1.22–4.87; p = .0087), respectively, for early mortality. In multivariate analysis, a high Composite Immune Risk Score during days 91–180 remained an independent risk factor for early mortality after allogeneic HSCT (HR, 1.80; 95% C.I., 1.28–2.55; p = .00085). In conclusion, the Composite Immune Risk Score is easy to compute and could identify the high‐risk patients of allogeneic HSCT who require targeted effort for prevention and control of infection.

Refining eligibility criteria of unit selection for myeloablative cord blood transplantation in acute leukemia: Real‐world experience of a referral center

“…Cord blood (CB) is an important alternative source of allogeneic transplants, especially if we consider its shorter wait time, superior anti‐leukemia effect [ 1 , 2 ], and comparatively faster long‐term immune reconstitution [ 3 ]. Donor selection for umbilical CB transplantation (UCBT) needs to consider multiple factors [ 4 ], and a few issues still remain:…”