THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Alexander, Stephen P.H.; Mathie, Alistair; Peters, John A.; Veale, Emma L.; Striessnig, Jörg; Kelly, Eamonn; Armstrong, Jane F.; Faccenda, Elena; Harding, Simon D; Pawson, Adam J.; Southan, Christopher; Davies, Jamie A.; Aldrich, Richard W.; Attali, Bernard; Baggetta, Austin M.; Becirovic, Elvir; Biel, Martin; Bill, Roslyn M.; Catterall, William A.; Conner, Alex C.; Davies, Paul; Delling, Markus; Virgilio, Francesco Di; Falzoni, Simonetta; Fenske, Stefanie; Chandy, George; Goldstein, Steve A.N.; Grissmer, Stephan; Ha, Kotdaji; Hammelmann, Verena; Hanukoglu, Israel; Jarvis, Mike; Jensen, Anders A.; Kaczmarek, Leonard K.; Kellenberger, Stephan; Kennedy, Charles; King, Brian; Kitchen, Philip; Lynch, Joseph W.; Perez‐Reyes, Edward; Plant, Leigh D.; Rash, Lachlan D.; Ren, Dejian; Salman, Mootaz M.; Sivilotti, Lucia G.; Smart, Trevor G.; Snutch, Terrance P.; Tian, Jin Bin; Trimmer, James S.; Eynde, Charlotte Van den; Vriens, Joris; Wei, Aguan; Winn, Brenda T.; Wulff, Heike; Xu, Haoxing; Yue, Lixia; Zhang, Xiaoli; Zhu, Michael X.

doi:10.1111/bph.15539

Cited by 208 publications

(172 citation statements)

References 309 publications

(416 reference statements)

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“…These break down adrenergic and serotonin pathways inside the locus coeruleus and raphe nuclei in rodents. The perceived neurodegeneration and dysregulation of the glial–neuron communication plays a vital role in AD pathologies and proression [ 64 , 65 ].…”

Section: Triggering Receptors Expressed On Myeloid Cell-2 (Trem2) Receptormentioning

confidence: 99%

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda¹,

Singh

Patel

et al. 2022

Brain Sciences

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The human brain maintains billions of neurons functional across the lifespan of the individual. The glial, supportive cells of the brain are indispensable to neuron elasticity. They undergo various states (active, reactive, macrophage, primed, resting) and carefully impose either quick repair or the cleaning of injured neurons to avoid damage extension. Identifying the failure of these interactions involving the relation of the input of glial cells to the inception and/or progression of chronic neurodegenerative diseases (ND) is crucial in identifying therapeutic options, given the well-built neuro-immune module of these diseases. In the present review, we scrutinize different interactions and important factors including direct cell–cell contact, intervention by the CD200 system, various receptors present on their surfaces, CXC3RI and TREM2, and chemokines and cytokines with special reference to Alzheimer’s disease (AD). The present review of the available literature will elucidate the contribution of microglia and astrocytes to the pathophysiology of AD, thus evidencing glial cells as obligatory transducers of pathology and superlative targets for interference.

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Section: Triggering Receptors Expressed On Myeloid Cell-2 (Trem2) Receptormentioning

confidence: 99%

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Chavda¹,

Singh

Patel

et al. 2022

Brain Sciences

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“…Mucolipins are non-selective (Na + > K + > Ca 2+ ) [ 17 ] cation channels involved in endolysosomal trafficking, fusion/fission, lysosomal pH regulation, autophagy, lysosomal exocytosis, and endocytosis. While mutations in TRPML1 cause the neurodegenerative lysosomal storage disorder mucolipidosis IV (MLIV), its relatives TRPML2 and TRPML3 are not associated with disease causing human mutations.…”

Section: Trpml3—regulator Of Mmp-12 Levels In Bronchoalveolar Fluid: Early Endosomes Of Alveolar Macrophagesmentioning

confidence: 99%

“…TRPV2 belongs to the vanilloid (V) receptor subfamily of TRP channels, is permeable for Ca 2+ and Na + (PCa/PNa = 0.9–2.9) [ 17 ], and is related to the heat, pain and capsaicin receptor TRPV1. A role for TRPV2 in COPD and phagocytosis has been proposed recently by Masubuchi and colleagues [ 24 ].…”

Section: Trpv2—critical Player In Alveolar Macrophage Phagocytosis: Cell Membrane or Early Endosome?mentioning

confidence: 99%

“…TRPM2 belongs to the melastatin (M) subfamily of TRP channels, is non-selectively permeable for Ca 2+ and Na + [ 17 ] (PCa/PNa = 0.6–0.7), and is activated by intracellular adenosine diphosphate ribose (ADPR). TRPM2 activation is further facilitated by nicotinic acid adenine dinucleotide phosphate (NAADP), cyclic ADPR, and hydrogen peroxide (H 2 O 2 ) [ 28 ].…”

Section: Trpm2—protective Role In Lung Inflammation: Cell Membrane or Lysosome?mentioning

confidence: 99%

“…TRPA1 is the only mammalian member of the TRPA subfamily of TRP channels is permeable for Ca 2+ and Na + (PCa/PNa = 0.84) [ 17 ], and contains 16 N-terminal ankyrin repeats in humans. TRPA1 is a chemosensor activated by a plethora of molecules including isothiocyanates, cinnamaldehyde, acrolein, nicotine, formalin, hydrogen peroxide, tear gases, and other reactive chemicals, prostaglandins, NGF, bradykinin, and histamine [ 6 , 33 ].…”

Section: Trpa1—a Target For Cough Asthma Copd? Ca 2+ From Lysosomes Involved?mentioning

confidence: 99%

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Endolysosomal Cation Channels and Lung Disease

Spix

Jeridi

Ansari

et al. 2022

Cells

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Endolysosomal cation channels are emerging as key players of endolysosomal function such as endolysosomal trafficking, fusion/fission, lysosomal pH regulation, autophagy, lysosomal exocytosis, and endocytosis. Diseases comprise lysosomal storage disorders (LSDs) and neurodegenerative diseases, metabolic diseases, pigmentation defects, cancer, immune disorders, autophagy related diseases, infectious diseases and many more. Involvement in lung diseases has not been a focus of attention so far but recent developments in the field suggest critical functions in lung physiology and pathophysiology. Thus, loss of TRPML3 was discovered to exacerbate emphysema formation and cigarette smoke induced COPD due to dysregulated matrix metalloproteinase 12 (MMP-12) levels in the extracellular matrix of the lung, a known risk factor for emphysema/COPD. While direct lung function measurements with the exception of TRPML3 are missing for other endolysosomal cation channels or channels expressed in lysosome related organelles (LRO) in the lung, links between those channels and important roles in lung physiology have been established such as the role of P2X4 in surfactant release from alveolar epithelial Type II cells. Other channels with demonstrated functions and disease relevance in the lung such as TRPM2, TRPV2, or TRPA1 may mediate their effects due to plasma membrane expression but evidence accumulates that these channels might also be expressed in endolysosomes, suggesting additional and/or dual roles of these channels in cell and intracellular membranes. We will discuss here the current knowledge on cation channels residing in endolysosomes or LROs with respect to their emerging roles in lung disease.

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Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels

Krylov,

Tabakmakher,

Yureva

et al. 2023

Protein Science

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Here, we introduce the third release of Kalium database (http://kaliumdb.org/), a manually curated comprehensive depository that accumulates data on polypeptide ligands of potassium channels. The major goal of this amplitudinous update is to summarize findings for natural polypeptide ligands of K+ channels, as well as data for the artificial derivatives of these substances obtained over the decades of exploration. We manually analyzed more than 700 original manuscripts and systematized the information on mutagenesis, production of radio‐ and fluorescently labeled derivatives, and the molecular pharmacology of K+ channel ligands. In result, data on more than 1200 substances were processed and added enriching the database content fivefold. We also included the electrophysiological data obtained on the understudied and neglected K+ channels including the heteromeric and concatenated channels. We associated target channels in Kalium with corresponding entries in the official database of the International Union of Basic and Clinical Pharmacology (IUPHAR). Kalium was supplemented with an adaptive Statistics page, where users are able to obtain actual data output. Several other improvements were introduced, such as a color code to distinguish the range of ligand activity concentrations and advanced tools for filtration and sorting. Kalium is a fully open‐access database, crosslinked to other databases of interest. It can be utilized as a convenient resource containing ample up‐to‐date information about polypeptide ligands of K+ channels.This article is protected by copyright. All rights reserved.

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THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

Cited by 208 publications

References 309 publications

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Neuronal Glial Crosstalk: Specific and Shared Mechanisms in Alzheimer’s Disease

Endolysosomal Cation Channels and Lung Disease

Kalium 3.0 is a comprehensive depository of natural, artificial, and labeled polypeptides acting on potassium channels

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