2021
DOI: 10.3390/ijms22189697
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The Connection between Czc and Cad Systems Involved in Cadmium Resistance in Pseudomonas putida

Abstract: Heavy metal pollution is widespread and persistent, and causes serious harm to the environment. Pseudomonas putida, a representative environmental microorganism, has strong resistance to heavy metals due to its multiple efflux systems. Although the functions of many efflux systems have been well-studied, the relationship between them remains unclear. Here, the relationship between the Czc and Cad systems that are predominantly responsible for cadmium efflux in P. putida KT2440 is identified. The results demons… Show more

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Cited by 21 publications
(10 citation statements)
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“…As such, the four ZntA P-type transporting ATPases (PSDM-0653, PSDM-1071, PSDM-1166, and PSDM-4297) in particular may mediate resistance to Zn 2+ , Cd 2+ , and Pb 2+ [28], and heavy metals could be transported by the resistancenodulation-division (RND) family efflux transporters PSDM-0708 and PSDM-4729 [29,30]. CzcA (PSDM-3120, PSDM-0710, and PSDM-1540) and CzcB (PSDM-0709) heavy metal proteins are involved in the efflux of metal ions such as Cd 2+ [31,32]. The chromate transport protein ChrA (PSDM-0705 and PSDM-4465) is involved in the chromate efflux system and has been shown to enhance the chromate tolerance capacity [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…As such, the four ZntA P-type transporting ATPases (PSDM-0653, PSDM-1071, PSDM-1166, and PSDM-4297) in particular may mediate resistance to Zn 2+ , Cd 2+ , and Pb 2+ [28], and heavy metals could be transported by the resistancenodulation-division (RND) family efflux transporters PSDM-0708 and PSDM-4729 [29,30]. CzcA (PSDM-3120, PSDM-0710, and PSDM-1540) and CzcB (PSDM-0709) heavy metal proteins are involved in the efflux of metal ions such as Cd 2+ [31,32]. The chromate transport protein ChrA (PSDM-0705 and PSDM-4465) is involved in the chromate efflux system and has been shown to enhance the chromate tolerance capacity [33,34].…”
Section: Discussionmentioning
confidence: 99%
“…Among them, ycf16 and aztA are direct ATP-dependent primary transporters for toxic compound extrusion from the cytoplasm across the periplasmic space to the outside of the cell, whereas all7618 , all7619 , and alr4267 are secondary transporters that are usually energized by the electrochemical gradients established by primary active transport (Li et al, 2002; Anes et al, 2015). All of these transporters have been proven previously to confer Cd tolerance in a variety of organisms, including cyanobacteria, by effluxing Cd out of the cell (Nesler et al, 2017; Xu et al, 2018; Victoria et al, 2018; Fu et al, 2019; Liu et al, 2021; Srivastava et al, 2021b). The transcript levels of ycf1 ( alr2493 ), an ABC transporter ATP-binding protein, which is organized in the form of an operon ( alr2492 - alr2493 - alr2494 - alr2495 - alr2496 ), and a single gene aztA , a Cd-specific P-type ATPase, increased in response to LexA overexpression under unstressed condition (Fig.…”
Section: Discussionmentioning
confidence: 99%
“…CDF systems, acting as chemiosmotic antiporters, co‐transport cadmium to the periplasm and protons to the cytoplasm, but like CadA transporters they are unable to extrude metals from the periplasm to the extracellular space. In Pseudomonas , the expression of cadA gene stimulates the rapid induction of the CzcCBA efflux system, which is an RND‐type cation extruder that functions not only for cadmium, but also for bivalent zinc and cobalt (Ducret et al., 2020 ; Liu et al., 2021 ). CzcA is the inner membrane component (RND protein) while CzcC is the outer membrane factor (OMF) that spans from the periplasm to the extracellular space.…”
Section: Bacterial Resistance and Detoxification Of Industrial Cyanid...mentioning
confidence: 99%