The connection between the clinical picture of myocardial infarction associated with cardiorenal syndrome with NOS3 gene polymorphism and systemic inflammatory response

Siverina, A. V.; Викторовна, Сиверина Анна; Скородумова, Е. Г.; Андреевна, Скородумова Елена; Костенко, В. А.; Авенирович, Костенко Виктор; Пивоварова, Л. П.; Павловна, Пивоварова Людмила; Ariskina, O. B.; Борисовна, Арискина Ольга; Малышев, М. Е.; Евгеньевич, Малышев Михаил; Геннадьевна, Скородумова Елизавета; Рысев, А В; Васильевич, Рысев Александр; Федоров, А. Н.; Николаевич, Фёдоров Артём

doi:10.17816/mechnikov201810415-22

Cited by 2 publications

(1 citation statement)

References 14 publications

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“…Полиморфизм этого гена обуславливает недостаток наработки фермента, который является причиной снижения синтеза и высвобождения NO, что может привести к дисфункции эндотелия, а также служить основой для развития ИБС [3,4]. Отмечено наличие ассоциации гетерозиготного и гомозиготного вариантов гена NOS3 с повышенной агрегацией тромбоцитов и острым коронарным синдромом [5,6], острым почечным повреждением у пациентов с инфарктом миокарда (ИМ) [7], артериальной гипертензией [8], а также инсулинрезистентностью [9].…”

Section: Introductionunclassified

Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting

Magamadov

Skorodumova

Костенко

et al. 2022

Transl. med. (Print)

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Background. Development of personalized medicine and study of the genetic basis of cardiovascular diseases are promising areas in modern cardiology.Objective. To evaluate effect of NOS3 gene polymorphism on the prognosis in patients undergoing coronary artery bypass grafting (CABG).Design and methods. The study included 60 patients with stable coronary heart disease (CAD) and multivessel coronary disease according to the SYNTAX I score > 23. The first group included 39 patients — carriers of the 786CC and 786TC genotypes, the second — 21 patients with the 786TT genotype of the NOS3 gene. We accessed the severity of the systemic inflammatory response (SIR) in the postoperative period, the dynamics of changes in the ejection fraction (EF) of the left ventricle, as well as clinical data during 12 months after CABG.Results. The presence of heterozygous and homozygous variants (TC/CC) of the NOS3 gene is associated with a more pronounced and prolonged SIR in the postoperative period. The chances of developing symptoms of acute decompensation of chronic heart failure (CHF) within 12 months after CABG were significantly 4 higher in the group of carriers of TC/CC genotypes.Conclusions. In patients with CAD and carriage of the 786TC/786CC genotypes of the NOS3 gene undergoing CABG, there is a more pronounced and prolonged SIR in the postoperative period, as well as an increased risk of acute decompensation of CHF within 12 months after CABG.

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Section: Introductionunclassified

Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting

Magamadov

Skorodumova

Костенко

et al. 2022

Transl. med. (Print)

View full text Add to dashboard Cite

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Study on Cardiac Transcriptomic Changes and Inflammatory Responses Induced by Acute Kidney Injury in a Cardiorenal Syndrome Model

DING,

HE,

LIU

et al. 2024

Preprint

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Cardiorenal syndrome (CRS) is a multifaceted relationship between the heart and kidney, where acute kidneys injury (AKI) directly contributes to cardiac dysfunction. The present study aimed to explore the changes of early transcriptome in heart exposed AKI via a mouse unilateral ureteral obstruction (UUO) model. This study was designed to extract differentially expressed genes (DEGs) and their implicated biological processes as well as pathways from the GSE235751 dataset of high-throughput gene expression profile via bioinformatics tools. Preprocessing-introduction of Data was undergone for data integrity and quality check, Differential expression analysis that identified significant gene expressions changes in heart tissue associated with AKI. Pathway analysis and functional annotation revealed involvement of inflammation, cardiac repair, mitochondrial function and autophagy as the major pathways influencing differences in gene expression. Between unrelated groups, validation of distinctly expressed genes was performed using Principal Component Analysis (PCA) and t-Distributed Stochastic Neighbor Embedding (t-SNE). Gene Set Enrichment Analysis (GSEA) showed downregulation of mitochondrial oxidative bioenergetics and autophagy, while upregulating cell proliferation inflammation pathways. These results indicate that AKI induces robust changes in cardiac gene expression, affecting many different pathways and provide novel information about the molecular mechanisms underlying CRS. These results identify possible early intervention and therapeutic targets for the better understanding and treatment of CRS.

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The connection between the clinical picture of myocardial infarction associated with cardiorenal syndrome with NOS3 gene polymorphism and systemic inflammatory response

Cited by 2 publications

References 14 publications

Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting

Influence of endothelial nitric oxide syntase gene polymorphism on prognosis in patients after coronary bypass grafting

Study on Cardiac Transcriptomic Changes and Inflammatory Responses Induced by Acute Kidney Injury in a Cardiorenal Syndrome Model

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