The Constant Pressure Term (PO) of the Volume-Pressure Relationship. Comparison Between Results of Infusion Test and Pulse Pressure Analysis

Eijndhoven, J. H. M. van; Sliwka, S; Avezaat, C. J. J.

doi:10.1007/978-3-642-70971-5_9

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…In Table 2, the k E values vary from about one-half of normal (which means good intracranial compliance) to more than twice normal (poor compliance). These values are in the range reported in the clinical literature for patients with various intracranial diseases (1,8,9). R o is significantly increased in most patients.…”

Section: Parameter Identificationsupporting

confidence: 68%

Intracranial pressure dynamics in patients with acute brain damage: a critical analysis with the aid of a mathematical model

Ursino

Iezzi

Stocchetti³

1995

IEEE Trans. Biomed. Eng.

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The time pattern of intracranial pressure (ICP) in response to typical clinical tests (i.e., bolus injection and bolus withdrawal of 1 to 4 mL of saline in the craniospinal space) was studied in 18 patients with acute brain damage by means of a mathematical model. The model includes the main biomechanical factors assumed to affect intracranial pressure, particularly cerebrospinal fluid (CSF) dynamics, intracranial compliance, and cerebral hemodynamics. Best fitting between model simulation curves and clinical tracings was achieved using the Powell minimization algorithm and a least-square criterion function. The simulation results demonstrate that, in most patients, the ICP time pattern cannot be explained merely on the basis of CSF dynamics but also requires consideration of the contribution of cerebral hemodynamics and blood volume alterations. In particular, only in a few patients (about 40% of total) the ICP monotonically returns toward baseline following the clinical maneuver. In most of the examined cases (about 60%), ICP exhibits an anomalous response to the same maneuver, characterized by a delayed increase after bolus injection and a delayed decrease after withdrawal. The model is able to explain these responses, imputing them to active intracranial blood volume changes induced by mechanisms controlling cerebral blood flow. Finally, the role of the main intracranial biomechanical parameters in the genesis of the ICP time pattern is discussed and a comparison with previous theoretical studies performed.

show abstract

Section: Parameter Identificationsupporting

confidence: 68%

Intracranial pressure dynamics in patients with acute brain damage: a critical analysis with the aid of a mathematical model

Ursino

Iezzi

Stocchetti³

1995

IEEE Trans. Biomed. Eng.

View full text Add to dashboard Cite

show abstract

“…These values are in the range reported in the clinical literature for patients with various intracranial diseases (1,8,9).…”

Section: Parameter Identificationsupporting

confidence: 68%

“…The k E is 0.05-0.25 ml 21 (Table 1). According to various authors (1,8,9), normal values for k E are 0.05-0.15 ml 21 , whereas values as high as 0.25 ml 21 are often found in patients with severe brain disorders.…”

Section: Discussionmentioning

confidence: 99%

Intracranial pressure dynamics in patients with acute brain damage

Ursino

Lodi

Rossi³

et al. 1997

Journal of Applied Physiology

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Biomathematics of Intracranial CSF and Haemodynamics. Simulation and Analysis with the Aid of a Mathematical Model

Hoffmann

1987

Primary and Secondary Brain Stem Lesions

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The Constant Pressure Term (PO) of the Volume-Pressure Relationship. Comparison Between Results of Infusion Test and Pulse Pressure Analysis

Cited by 6 publications

References 6 publications

Intracranial pressure dynamics in patients with acute brain damage: a critical analysis with the aid of a mathematical model

Intracranial pressure dynamics in patients with acute brain damage: a critical analysis with the aid of a mathematical model

Intracranial pressure dynamics in patients with acute brain damage

Biomathematics of Intracranial CSF and Haemodynamics. Simulation and Analysis with the Aid of a Mathematical Model

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