The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure – Effects in reproductive organs

Brunnberg, Sara; Andersson, Patrik; Poellinger, Lorenz; Hanberg, Annika

doi:10.1016/j.chemosphere.2011.09.015

Cited by 19 publications

(16 citation statements)

References 42 publications

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“…2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and dioxin-like compounds have been shown to transcriptionally regulate specific genes (1, 68, 69), which may affect pubertal onset and tempo. Several mechanisms have been suggested to describe the AhR mediated interference of steroid hormone regulated responses (70–72).…”

Section: Resultsmentioning

confidence: 99%

The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children’s Study

Sergeyev

Burns

Williams

et al. 2017

Reviews on Environmental Health

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Abstract Organochlorine chemicals and lead are environmental exposures that have endocrine disrupting properties (EDCs) which interfere with many aspects of hormone action. Childhood and adolescence are windows of susceptibility for adverse health effects of EDCs. Our ongoing study, the Russian Children’s Study (RCS), is one of the few longitudinal studies investigating the impact of EDCs on growth and puberty in boys. It is conducted in the historically contaminated city of Chapaevsk, in the Samara region. The study focuses on evaluating the associations of persistent organochlorine chemicals and lead with growth and pubertal timing. At enrollment in 2003–2005, we collected blood from 516 boys at ages 8–9 years to measure dioxins, furans, polychlorinated biphenyls (PCBs), chlorinated pesticides and lead. At enrollment and at annual visits through the ages of 18–19 years, a physician performed physical examinations that included pubertal staging and testicular volume measurements. We review the history of Chapaevsk as a research site and summarize published RCS data on the association of peripubertal serum concentrations of organochlorines and blood lead levels with growth, pubertal onset and sexual maturity. Overall, we found that persistent organochlorines and lead negatively affected growth during puberty. Our results also suggest that total toxic equivalents (TEQs), dioxin-like compounds, organochlorine pesticides and lead may delay, while nondioxin-like-PCBs may advance, the timing of male puberty. These findings promoted remediation programs in Chapaevsk, with improvement in health indicators, resulting in Chapaevsk being designated a member of the World Health Organization (WHO) network “Healthy Cities” in 2015.

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Section: Resultsmentioning

confidence: 99%

The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children’s Study

Sergeyev

Burns

Williams

et al. 2017

Reviews on Environmental Health

View full text Add to dashboard Cite

show abstract

“…In contrast to the above two viewpoints, Spink and his collaborators thought TCDD-induced AhR expression had no relationship with the proliferation and estrogen-stimulated tumor formation of MCF-7 cells [73]. However, dioxin receptor and ER signaling shows crosstalk, and dioxin-activated AhR expressed antiestrogenic effects depending on estrogen, but estrogenic effects are independent of estrogen [9,[74][75]. Therefore, the mechanism of the relationship between dioxins and breast cancer is still unclear.…”

Section: Dioxinsmentioning

confidence: 89%

Evaluating Breast Cancer Risk under Exposure to Environmental Estrogen-Like Chemicals

He¹,

Wang²,

Wu³

2016

Pol. J. Environ. Stud.

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“…Conversely, transgenic mice with a constitutively active AHR spontaneously develop tumors, their weights of testis and ventral prostate are decreased and the epididymal sperm reserve is reduced (Brunnberg et al, 2011). Furthermore, AHRR, the negative regulator of AHR signaling, functions as a tumor suppressor in multiple human tumors (Zudaire et al, 2008; Li et al, 2012).…”

Section: Discussionmentioning

confidence: 99%

Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer

Brokken¹,

Lundberg-Giwercman²,

Meyts³

et al. 2013

Front. Endocrin.

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In the Western world, testicular germ cell cancer (TGCC) is the most common malignancy of young men. The malignant transformation of germ cells is thought to be caused by developmental and hormonal disturbances, probably related to environmental and lifestyle factors because of rapidly increasing incidence of TGCC in some countries. Additionally, there is a strong genetic component that affects susceptibility. However, genetic polymorphisms that have been identified so far only partially explain the risk of TGCC. Many of the persistent environmental pollutants act through the aryl hydrocarbon receptor (AHR). AHR signaling pathway is known to interfere with reproductive hormone signaling, which is supposed to play a role in the pathogenesis and invasive progression of TGCC. The aim of the present study was to identify whether AHR-related polymorphisms were associated with risk as well as histological and clinical features of TGCC in 367 patients and 537 controls. Haplotype-tagging single-nucleotide polymorphisms (SNPs) were genotyped in genes encoding AHR and AHR repressor (AHRR). Binary logistic regression was used to calculate the risk of TGCC, non-seminoma versus seminoma, and metastasis versus localized disease. Four SNPs in AHRR demonstrated a significant allele association with risk to develop metastases (rs2466287: OR = 0.43, 95% CI 0.21–0.90; rs2672725: OR = 0.49, 95% CI: 0.25–0.94; rs6879758: OR = 0.27, 95% CI: 0.08–0.92; rs6896163: OR = 0.34, 95% CI: 0.12–0.98). This finding supports the hypothesis that compounds acting through AHR may play a role in the invasive progression of TGCC, either directly or through modification of reproductive hormone action.

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The constitutively active Ah receptor (CA-AhR) mouse as a model for dioxin exposure – Effects in reproductive organs

Cited by 19 publications

References 42 publications

The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children’s Study

The association of peripubertal serum concentrations of organochlorine chemicals and blood lead with growth and pubertal development in a longitudinal cohort of boys: a review of published results from the Russian Children’s Study

Evaluating Breast Cancer Risk under Exposure to Environmental Estrogen-Like Chemicals

Association between polymorphisms in the aryl hydrocarbon receptor repressor gene and disseminated testicular germ cell cancer

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