The contribution of solid-state NMR spectroscopy to understanding biomineralization: Atomic and molecular structure of bone

Duer, Melinda J.

doi:10.1016/j.jmr.2014.12.011

Cited by 72 publications

(63 citation statements)

References 62 publications

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“…Recently, it has been shown that citrate in bone has a critical role in anchoring mineral platelets to their collagenous matrix. 10 Also, trapped between the platelets are many water molecules. 10 The ratio of length to thickness in mineral platelets (their 'aspect ratio') is critical in delivering the stiffness needed in properly functioning cortical bone.…”

Section: Cortical Bone As a Tough Materialsmentioning

confidence: 99%

“…10 Also, trapped between the platelets are many water molecules. 10 The ratio of length to thickness in mineral platelets (their 'aspect ratio') is critical in delivering the stiffness needed in properly functioning cortical bone. Young adult bone tissue achieves toughness both through limiting the growth of crystal size and through the behavioural properties of the proteinaceous substrate when subjected to shear forces.…”

Section: Cortical Bone As a Tough Materialsmentioning

confidence: 99%

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Role of cortical bone in hip fracture

Reeve

2017

BoneKEy Rep

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In this review, I consider the varied mechanisms in cortical bone that help preserve its integrity and how they deteriorate with aging. Aging affects cortical bone in two ways: extrinsically through its effects on the individual that modify its mechanical loading experience and 'milieu interieur'; and intrinsically through the prolonged cycle of remodelling and renewal extending to an estimated 20 years in the proximal femur. Healthy femoral cortex incorporates multiple mechanisms that help prevent fracture. These have been described at multiple length scales from the individual bone mineral crystal to the scale of the femur itself and appear to operate hierarchically. Each cortical bone fracture begins as a sub-microscopic crack that enlarges under mechanical load, for example, that imposed by a fall. In these conditions, a crack will enlarge explosively unless the cortical bone is intrinsically tough (the opposite of brittle). Toughness leads to microscopic crack deflection and bridging and may be increased by adequate regulation of both mineral crystal size and the heterogeneity of mineral and matrix phases. The role of osteocytes in optimising toughness is beginning to be worked out; but many osteocytes die in situ without triggering bone renewal over a 20-year cycle, with potential for increasing brittleness. Furthermore, the superolateral cortex of the proximal femur thins progressively during life, so increasing the risk of buckling during a fall. Besides preserving or increasing hip BMD, pharmaceutical treatments have class-specific effects on the toughness of cortical bone, although dietary and exercise-based interventions show early promise.

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Section: Cortical Bone As a Tough Materialsmentioning

confidence: 99%

Section: Cortical Bone As a Tough Materialsmentioning

confidence: 99%

Role of cortical bone in hip fracture

Reeve

2017

BoneKEy Rep

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“…According to a recent model of the nanostructure of bone (Duer ), in part derived from results of nuclear magnetic resonance (NMR) spectroscopy, apatite particles, the mineral building units, possess a crystalline core and an amorphous hydrated surface layer (Wilson et al . , ).…”

Section: Introductionmentioning

confidence: 99%

“…According to a recent model of the nanostructure of bone (Duer 2015), in part derived from results of nuclear magnetic resonance (NMR) spectroscopy, apatite particles, the mineral building units, possess a crystalline core and an amorphous hydrated surface layer (Wilson et al 2004(Wilson et al , 2006. The particles are arranged in stacks of platelets (8-40 nm long, 5-25 nm wide and about 2.5 nm thick) aligned parallel to the c-axis of the hexagonal unit cell (platelet elongation).…”

Section: Introductionmentioning

confidence: 99%

The Assessment of Bone Deterioration with Nuclear Magnetic Resonance Spectroscopy in a Multidisciplinary Context: The Case of the UNESCO World Heritage Site of Sedlec, Czechia

et al. 2019

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Human remains from the skeletal collection of the UNESCO world heritage site of Sedlec (Czechia) have been investigated with 1H, 31P and 13C magic‐angle‐spinning nuclear magnetic resonance spectroscopy. The quantitative description of the component of the phosphorus signal attributed to the external amorphous hydrated layer of the mineral apatite particles is considered a sensitive index of the bone integrity, in general agreement with indicators of decay derived from other analytical techniques. Differences in proton and phosphorus resonances were related to deterioration effects, allowing for the identification of local conditions posing a threat to bone preservation.

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“…Solid-state NMR spectroscopy is a powerful analytical tool that is widely used for studying molecular structures and dynamics of a variety of solids including membrane proteins, [1][2][3][4][5] multiphase polymers [6][7][8], bone materials, [9][10][11] amyloids [12][13][14][15][16][17], and nanocomposites [18][19][20][21]. The benefits of multidimensional NMR techniques to obtain higher resolution and higher degree of structural and dynamic information have been well utilized in numerous applications, among which 2D homonuclear (HOMCOR) [22][23][24][25] and heteronuclear (HETCOR) [26][27][28][29][30][31] chemical shift correlation experiments are most widely employed and have become indispensable for structural studies of proteins.…”

Section: Introductionmentioning

confidence: 99%

Exploiting Heterogeneous Time Scale of Dynamics to Enhance 2D HETCOR Solid-State NMR Sensitivity

Zhang

Nishiyama

Ramamoorthy

2019

Preprint

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to obtain 2D 13 C/ 1 H chemical shift correlation spectra of rigid and mobile components independently and separately. These pulse sequences can be used for dynamics difference based spectral editing and resonance assignments. Therefore, we believe the proposed 2D HETCOR NMR pulse sequences will be beneficial for the structural studies of heterogeneous systems containing molecular components that differ in their time scale of motions for understanding the interplay of structures and properties.

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The contribution of solid-state NMR spectroscopy to understanding biomineralization: Atomic and molecular structure of bone

Cited by 72 publications

References 62 publications

Role of cortical bone in hip fracture

Role of cortical bone in hip fracture

The Assessment of Bone Deterioration with Nuclear Magnetic Resonance Spectroscopy in a Multidisciplinary Context: The Case of the UNESCO World Heritage Site of Sedlec, Czechia

Exploiting Heterogeneous Time Scale of Dynamics to Enhance 2D HETCOR Solid-State NMR Sensitivity

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