The Controversies, Challenges and Complexities of Lyme Disease: A Narrative Review

Hout, Marie Claire Van

doi:10.18433/jpps30254

Cited by 19 publications

(12 citation statements)

References 66 publications

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“…Laimo ligos paplitimas ir sergamumas didėja visame pasaulyje [1]. Kai kuriems asmenims, sirgusiems Laimo liga, po gydymo išlieka nespecifinių simptomų [2], todėl siekta išsiaiškinti, kaip liekamieji simptomai sutrikdo asmenų, sirgusių Laimo liga, veiklą.…”

Section: Santraukaunclassified

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Laimo Liga Sirgusių Asmenų Kasdienės, Darbinės Ir Laisvalaikio Veiklos Problemos

Račkauskaitė¹,

Baltaduonienė²

2021

Health Sciences

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Laimo ligos paplitimas ir sergamumas didėja visame pasaulyje [1]. Kai kuriems asmenims, sirgusiems Laimo liga, po gydymo išlieka nespecifinių simptomų [2], todėl siekta išsiaiškinti, kaip liekamieji simptomai sutrikdo asmenų, sirgusių Laimo liga, veiklą. Tyrimo medžiaga ir metodai. Atliktas kokybinis tyrimas. Duomenys rinkti pusiau struktūruoto interviu būdu. Pokalbio klausimai buvo suformuluoti iš anksto. Tyrimo rezultatai. Tyrime dalyvavę informantai atskleidė savo patirtį ir išgyvenimus, susijusius su Laimo ligos liekamaisiais simptomais. Tyrimo metu vertinant Laimo liga sirgusių asmenų kasdienės veiklos sunkumus, labiausiai buvo sutrikęs bendravimas dėl atminties susilpnėjimo ir išlikusių migruojančių skausmų. Tyrimo rezultatai atskleidė, kad daugiausia problemų darbinėje (produktyvioje) veikloje kėlė nuovargis ir silpnumas, mažinęs darbo našumą. Mažiausiai sutrikęs buvo laisvalaikis, tiktai kai kurie po ligos išlikę simptomai, tokie kaip migruojantys skausmai ar nuovargis, mažino motyvaciją veiklai, o padažnėjęs širdies plakimas ribojo galimybę užsiimti savo mėgstamu intensyvesniu sportu.

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Section: Santraukaunclassified

“…Laimo liga kelia vis didesnį pasaulio visuomenės susirūpinimą. Jos paplitimas ir sergamumas didėja ir tampa dažniausia pernešėjų platinama liga Europoje [1]. Remiantis Užkrečiamųjų ligų ir AIDS centro duomenimis, 2019 m. Lietuvoje buvo užregistruoti 3292 nauji Laimo ligos atvejai.…”

Section: įVadasunclassified

Laimo Liga Sirgusių Asmenų Kasdienės, Darbinės Ir Laisvalaikio Veiklos Problemos

Račkauskaitė¹,

Baltaduonienė²

2021

Health Sciences

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“…Lyme disease is an important and increasing global public health concern due to climate change and human activities (Dumic and Severnini, 2018;Van Hout, 2018). This disease is caused by spirochetes of the Borrelia burgdorferi sensu lato species complex, which are transmitted by infected Ixodes ticks (Rudenko et al, 2011).…”

Section: Borrelia Burgdorferimentioning

confidence: 99%

Emerging roles of non-coding RNAs in vector-borne infections

Bensaoud

Martins

Aounallah

et al. 2020

Journal of Cell Science

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Non-coding RNAs (ncRNAs) are nucleotide sequences that are known to assume regulatory roles previously thought to be reserved for proteins. Their functions include the regulation of protein activity and localization and the organization of subcellular structures. Sequencing studies have now identified thousands of ncRNAs encoded within the prokaryotic and eukaryotic genomes, leading to advances in several fields including parasitology. ncRNAs play major roles in several aspects of vector–host–pathogen interactions. Arthropod vector ncRNAs are secreted through extracellular vesicles into vertebrate hosts to counteract host defense systems and ensure arthropod survival. Conversely, hosts can use specific ncRNAs as one of several strategies to overcome arthropod vector invasion. In addition, pathogens transmitted through vector saliva into vertebrate hosts also possess ncRNAs thought to contribute to their pathogenicity. Recent studies have addressed ncRNAs in vectors or vertebrate hosts, with relatively few studies investigating the role of ncRNAs derived from pathogens and their involvement in establishing infections, especially in the context of vector-borne diseases. This Review summarizes recent data focusing on pathogen-derived ncRNAs and their role in modulating the cellular responses that favor pathogen survival in the vertebrate host and the arthropod vector, as well as host ncRNAs that interact with vector-borne pathogens.

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“…This may be illustrative of under-detection of Lyme disease in Canada [77], or that people suffering with unexplained symptoms look to Lyme disease as an explanation, leading many physicians and experts to call it a "catch-all disease" [76] (p136). The uncertainty and misinformation among participants re ect the complexities and controversies that surround the disease in public discourse and, to a lesser degree, the medical community [76,78,79].…”

Section: Key Findings Implicationsmentioning

confidence: 99%

Public perceptions of Lyme disease and climate change in southern Manitoba, Canada: Making a case for strategic decoupling of climate and health messages

Cameron

Rocque

Penner

et al. 2020

Preprint

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Background: Despite scientific evidence that climate change has profound and far reaching implications for public health, translating this knowledge in a manner that supports citizen engagement, applied decision-making, and behavioural change can be challenging. This is especially true for complex vector-borne zoonotic diseases such as Lyme disease, a tick-borne disease which is increasing in range and impact across Canada and internationally in large part due to climate change. This research aims to better understand public risk perceptions of climate change and Lyme disease in order to increase engagement and motivate behavioural change.Methods: A focus group study involving 61 participants was conducted in three communities in the Canadian Prairie province of Manitoba in 2019. Focus groups were segmented by urban, rural, and urban-rural geographies, and between participants with high and low levels of self-reported concern regarding climate change. Results: Findings indicate a broad range of knowledge and risk perceptions on both climate change and Lyme disease, which seem to reflect the controversy and complexity of both issues in the larger public discourse. Participants in high climate concern groups were found to have greater climate change knowledge, higher perception of risk, and less scepticism than those in low concern groups. Participants outside of the urban centre were found to have more familiarity with ticks, Lyme disease, and preventative behaviours, identifying potential differential sources of resilience and vulnerability. Risk perceptions of climate change and Lyme disease were found to vary independently rather than correlate, meaning that high climate change risk perception did not necessarily indicate high Lyme disease risk perception and vice versa. Conclusions: This research contributes to the growing literature framing climate change as a public health issue, and suggests that in certain cases climate and health messages might be strategically decoupled when addressing climate skeptical audiences. A model showing the orthogonal relationship between Lyme disease and climate change perceptions is proposed, and implications for engagement on climate change health impacts are discussed.

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The Controversies, Challenges and Complexities of Lyme Disease: A Narrative Review

Cited by 19 publications

References 66 publications

Laimo Liga Sirgusių Asmenų Kasdienės, Darbinės Ir Laisvalaikio Veiklos Problemos

Laimo Liga Sirgusių Asmenų Kasdienės, Darbinės Ir Laisvalaikio Veiklos Problemos

Emerging roles of non-coding RNAs in vector-borne infections

Public perceptions of Lyme disease and climate change in southern Manitoba, Canada: Making a case for strategic decoupling of climate and health messages

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