The cool things to know about TRPM8!

Iftinca, Mircea; Altier, Christophe

doi:10.1080/19336950.2020.1841419

Cited by 28 publications

(14 citation statements)

References 79 publications

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“…Gal + DRG neurons contain high level of tachykinin 1 ( Tac1 ), Calca , and TRP cation channel, subfamily V, member 1 ( Trpv1 ) ( 3 , 4 , 8 ), which can be activated by noxious heat. One subset of Gal + DRG neurons express Trpm8 at high level, which can be activated by innocuous to noxious cold temperatures ( 44 , 45 ). Thus, it would be interesting to further investigate the network derived from the different subsets of Gal + DRG neurons in the future.…”

Section: Discussionmentioning

confidence: 99%

Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors

Chen

Song

Wang

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Pain and itch are distinct sensations arousing evasion and compulsive desire for scratching, respectively. It’s unclear whether they could invoke different neural networks in the brain. Here, we use the type 1 herpes simplex virus H129 strain to trace the neural networks derived from two types of dorsal root ganglia (DRG) neurons: one kind of polymodal nociceptors containing galanin ( Gal ) and one type of pruriceptors expressing neurotensin ( Nts ). The DRG microinjection and immunosuppression were performed in transgenic mice to achieve a successful tracing from specific types of DRG neurons to the primary sensory cortex. About one-third of nuclei in the brain were labeled. More than half of them were differentially labeled in two networks. For the ascending pathways, the spinothalamic tract was absent in the network derived from Nts -expressing pruriceptors, and the two networks shared the spinobulbar projections but occupied different subnuclei. As to the motor systems, more neurons in the primary motor cortex and red nucleus of the somatic motor system participated in the Gal -containing nociceptor-derived network, while more neurons in the nucleus of the solitary tract (NST) and the dorsal motor nucleus of vagus nerve (DMX) of the emotional motor system was found in the Nts -expressing pruriceptor-derived network. Functional validation of differentially labeled nuclei by c-Fos test and chemogenetic inhibition suggested the red nucleus in facilitating the response to noxious heat and the NST/DMX in regulating the histamine-induced scratching. Thus, we reveal the organization of neural networks in a DRG neuron type-dependent manner for processing pain and itch.

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Section: Discussionmentioning

confidence: 99%

Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors

Chen

Song

Wang

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“…This suggests that the trigeminus nerve may be differentially affected in its different sensory components. Chemical sensitivity in trigeminal afferents involves receptors which are also temperature-gated ( 26 , 27 ), but cold receptors also exist ( 28 – 30 ), and functional specializations have been reported for trigeminal receptors ( 31 ). It is worth to include item 11 because it may discriminate among persons experiencing true chemosensory deficit from deceitful answers.…”

Section: Discussionmentioning

confidence: 99%

TaSCA, an Agile Survey on Chemosensory Impairments for Self-Monitoring of COVID-19 Patients: A Pilot Study

et al. 2021

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Background/Objective: During the COVID-19 pandemic, smell and taste disorders emerged as key non-respiratory symptoms. Due to widespread presence of the disease and to difficult objective testing of positive persons, the use of short surveys became mandatory. Most of the existing resources are focused on smell, very few on taste or trigeminal chemosensation called chemesthesis. However, it is possible that the three submodalities are affected differently by COVID-19.Methods: We prepared a short survey (TaSCA) that can be administered at the telephone or through online resources to explore chemosensation. It is composed of 11 items on olfaction, taste, and chemesthesis, in order to discriminate the three modalities. We avoided abstract terms, and the use of semiquantitative scales because older patients may be less engaged. Statistical handling included descriptive statistics, Pearson's chi-squared test and cluster analysis.Results: The survey was completed by 83 persons (60 females and 23 males), which reported diagnosis of COVID-19 by clinical (n = 7) or molecular (n = 18) means, the others being non-COVID subjects. Cluster analysis depicted the existence of two groups, one containing mostly asymptomatic and one mostly symptomatic subjects. All swab-positive persons fell within this second group. Only one item, related to trigeminal temperature perception, did not discriminate between the two groups.Conclusions: These preliminary results indicate that TaSCA may be used to easily track chemosensory symptoms related to COVID-19 in an agile way, giving a picture of three different chemosensory modalities.

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“…TRPM8 is a member of the cation channel family of TRP. As a cold sensory receptor, TRPM8 mainly senses temperature changes on the ocular surface and participates in temperature sensing, thermoregulation, and sensing pain caused by cold ( 11 , 14 , 16 , 59 ). TRPM8 is also involved in the pathophysiology of DE and has anti-hypersensitivity and antipruritic effects ( 15 , 60 ).…”

Section: Cold Receptors and Dementioning

confidence: 99%

Ocular Surface Ion-Channels Are Closely Related to Dry Eye: Key Research Focus on Innovative Drugs for Dry Eye

Yang

Wang

et al. 2022

Front. Med.

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Abundant ion-channels, including various perceptual receptors, chloride channels, purinergic receptor channels, and water channels that exist on the ocular surface, play an important role in the pathogenesis of dry eye. Channel-targeting activators or inhibitor compounds, which have shown positive effects in in vivo and in vitro experiments, have become the focus of the dry eye drug research and development, and individual compounds have been applied in clinical experimental treatment. This review summarized various types of ion-channels on the ocular surface related to dry eye, their basic functions, and spatial distribution, and discussed basic and clinical research results of various channel receptor regulatory compounds. Therefore, further elucidating the relationship between ion-channels and dry eye will warrant research of dry eye targeted drug therapy.

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The cool things to know about TRPM8!

Cited by 28 publications

References 79 publications

Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors

Distinct neural networks derived from galanin-containing nociceptors and neurotensin-expressing pruriceptors

TaSCA, an Agile Survey on Chemosensory Impairments for Self-Monitoring of COVID-19 Patients: A Pilot Study

Ocular Surface Ion-Channels Are Closely Related to Dry Eye: Key Research Focus on Innovative Drugs for Dry Eye

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