The Coraliance study: non-compliant behavior. Results after a 6-month follow-up of patients on oral contraceptives

Abstract

The importance of the phenomenon of non-compliance rate is confirmed as well as women's difficulties in knowing how to maintain contraceptive safety. The continuous cycle regimen is likely to improve women's compliance during the critical period of the cycle.

Ovulatory effects of three oral contraceptive regimens: a randomized, open-label, descriptive trial

“…Adherence to COC treatment regimens is variable, and poor adherence increases the risk of reduced ovarian suppression and escape ovulation, especially if the missed pills extend the HFI within a low-dose EE regimen [19,20]. The current study findings are consistent with previous studies showing that the addition of low-dose EE during the traditional HFI results in a delay in the rise of estradiol and provides effective suppression of ovarian follicular activity [8,13,14].…”

Effect of a Low-Dose Contraceptive Patch on Efficacy, Bleeding Pattern, and Safety: A 1-Year, Multicenter, Open-Label, Uncontrolled Study

“…However, poor compliance with this treatment is a common problem and can result in greatly impaired efficacy. 5 There are additional problems with COCs, such as the low bioavailability of EE (38%-48%) after oral administration, 6 rapid and large fluctuations in serum hormone concentrations, 7 and large intra-and interindividual pharmacokinetic variations. 8 Transdermal delivery of contraceptive hormones, in contrast, offers several advantages over oral administration, including effective absorption and the provision of relatively constant serum concentrations.…”

A comparison of bleeding patterns and cycle control using two transdermal contraceptive systems: a multicenter, open-label, randomized study

“…Overall, there was a numerically lower incidence of the EE-related TEAE of breast pain in the EE/GSD patch group compared with the EE/NGMN group (2 events in 1.0% of subjects versus 12 events in 4.0% of subjects, respectively). 2 The most common drug-related TEAEs are listed in Supplementary Table 1. Overall, 6.5% of subjects prematurely discontinued from study treatment due to TEAEs.…”

“…Daily oral contraceptives -presently the most common means of contraception in the developed world [1] -are highly effective when used correctly; however, poor compliance is common and can result in greatly reduced efficacy [2]. Moreover, oral contraceptives can be associated with rapid and large fluctuations in serum concentrations [3], large intra-and inter-individual pharmacokinetic variations in serum levels [4], and low bioavailability of ethinyl estradiol (EE; 38-48%) [5].…”