The Correlation Between Bispectral Index and Observational Sedation Scale in Volunteers Sedated with Dexmedetomidine and Propofol

Abstract

The combination of both BIS and sedative scales could provide different and complementary data to the clinician evaluating the patient's response to sedation than would either tool alone, especially when dexmedetomidine is used.

Effective dose of dexmedetomidine as an adjuvant sedative to peripheral nerve blockade in elderly patients

“…The correlation between electrophysiological and clinical assessments of sedation level remains controversial 31, 32, 33, 34…”

General Anesthesia With Dexmedetomidine and Remifentanil in a 3-Year-Old Child: An Alternative Anesthetic Regimen to Allay Parental Concerns of the Potential Neurocognitive Effects of General Anesthesia

“…Although it is accepted as an effective agent for providing sedation and anxiolysis, there are limited data to clearly demonstrate the amnestic effects of dexmedetomidine. In a randomized, cross-over trial, nine adults received either propofol or dexmedetomidine using computer-controlled infusions targeting an effect-site concentration of 1, 2, and 4 µg/mL for propofol or a plasma concentration of 0.6, 1.2, and 2.4 ng/mL for dexmedetomidine [28]. Using these graded infusions, the authors then compared the BIS number with the depth of sedation as assessed using the observer's assessment of alertness and sedation (OAA/S) score.…”

“…Higher dosing regimens may require assisted or controlled ventilation. However, when compared to other anesthetic agents such as propofol, there is less impairment of respiratory function with dexmedetomidine [28,31]. Adverse hemodynamic effects, albeit rare in the pediatric-aged patient, include bradycardia and hypotension.…”

Is Dexmedetomidine Better Than Midazolam for Monitored Anaesthesia Care During Inguinal Herniorrhaphy? A Comparative Study

“…4 Midazolam with its quick onset and offset of action still can cause prolonged sedation after repeated administration owing to its relatively long half-life. 3,5 Dexmedetomidine is a selective α2 receptor agonist with short elimination half-life of 2 hrs.…”

“…4,6,7 In the present study dexmedetomidine has been compared with midazolam as sedative component of Monitored Anaesthesia Care (MAC) in patients undergoing inguinal herniorrhaphy under inguinal field block. Injection fentanyl was used as rescue analgesic in both the groups when score in Visual Analog Scale score reached >4.…”