The Correlation Between Cardiometabolic Risks and High-Sensitivity C Reactive Protein (Hs-CRP) Levels in Serum Among Young Adults with Overweight and Obesity

Abstract

Introduction: The prevalence of overweight and obesity in young adults is increasing worldwide, including in Indonesia. Previous studies have shown that obesity increases inflammatory factors and is closely related to the incidence of metabolic and cardiovascular diseases. Cardiometabolic risk factors such as body mass index, waist circumference, dyslipidemia, fasting blood glucose levels, and blood pressure in young adults are thought to be associated with elevated serum Hs-CRP. Objective: This study aims to determine the correlation between cardiometabolic risks and serum High-Sensitivity C Reactive Protein (Hs-CRP) levels in young adults with overweight and obesity. Methods: This research was an analytical observational study with a cross-sectional design. The research subjects were young adults (20-40 years old) with overweight and obesity in Yogyakarta who met the inclusion and exclusion criteria. Cardiometabolic risks such as blood pressure, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, blood sugar, and serum levels of Hs-CRP were examined. The correlation between cardiometabolic risks and Hs-CRP levels was analyzed through the Pearson correlation test and declared significant if p < 0.05. Results: There was a significant positive correlation between the cardiometabolic risks of body mass index (p = 0.001; r = 0.526), fasting blood glucose levels (p = 0.013; r = 0.414), waist circumference (p = 0.00; r = 0.816), total cholesterol (p = 0.10; r = 0.428), LDL cholesterol (p = 0.01; r = 0.521), as well as HDL cholesterol (p = 0.00; r = -0.747) and serum Hs-CRP levels. No significant correlation was found between age, triglyceride levels, as well as blood pressure and serum Hs-CRP levels (p > 0.05). Conclusion: There is a significant positive correlation between the cardiometabolic risks of waist circumference, body mass index, total cholesterol, HDL cholesterols, LDL cholesterols, as well as fasting blood glucose levels and serum Hs-CRP levels.