The correlation between insulin-like growth factor 1 (IGF-1) and novel adipocytokines in postmenopausal women: A population-based study

Abstract

The adipocytokines and insulin-like growth factor 1 (IGF-1) are involved in insulin resistance, the cardiometabolic syndrome, and atherosclerosis. Therefore, investigating the relationship between circulating levels of the novel adipocytokines and IGF-1 is worthwhile. The correlation between IGF-1, visfatin, and omentin-1 has not been adequately investigated. In a population-based study, 324 postmenopausal women were randomly selected. Circulating IGF-1, visfatin, omentin-1, adiponectin, and high-sensitivity C-reactive protein (hs-CRP) levels were measured with the highly specific enzyme-linked immunosorbent assay method. In multiple regression analyses adjusted for alkaline phosphatase, osteocalcin, and hs-CRP, circulating IGF-1 was significantly correlated with visfatin levels (standardized β coefficient [β] = 0.13, partial correlation coefficient [r] = 0.12, p = 0.028). The significant positive correlation between serum IGF-1 and visfatin levels remained after additional adjustments for age and BMI (β = 0.12, r = 0.12, p = 0.025), metabolic syndrome (β = 0.13, r = 0.12, p = 0.021), and type 2 diabetes mellitus (β = 0.13, r = 0.12, p = 0.026). No significant correlations were found between IGF-1, adiponectin, and omentin-1. There is a significant correlation between serum IGF-1 and visfatin levels in postmenopausal women beyond metabolic syndrome, type 2 diabetes, bone formation markers, and hs-CRP levels. The observed correlation between higher circulating IGF-1 and the higher visfatin levels might be a physiological compensation and adaptation to protect against visfatin-induced proinflammatory effects. ARTICLE HISTORY

The effect of long-term ketogenic diet on serum adiponectin and insulin-like growth factor-1 levels in mice

“…This present study result showed that there was no significant correlation between IGF-1 and adiponectin levels. This finding is in line with several previous studies, where there was also no significant correlation between IGF-1 and adiponectin levels in healthy postmenopausal females and healthy elderly men [13,27]. However, correlation studies between adiponectin and IGF-1 levels still show inconsistent results.…”

“…Therefore, this study aimed to find out the longterm KD effect on serum adiponectin and IGF-1 levels in mice. A previous study regarding the correlation between adiponectin and IGF-1 showed that there was still an inconsistent association between adiponectin and IGF-1 [13]. Considering the involvement of adiponectin and IGF-1 in the development of several diseases, this study also evaluates the correlation between serum adiponectin and IGF-1 levels.…”