The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score

Decroli, Eva; Manaf, Asman; Syahbuddin, Syafril; Syafrita, Yuliarni; Dillasamola, Dwisari

doi:10.3889/oamjms.2019.029

Cited by 18 publications

(10 citation statements)

References 21 publications

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“…It has been reported that the increased level of IL-6 in the placenta of GDM patients is caused by oxidative stress and inflammatory changes caused by hyperglycemia (24). MDA is one of the most reliable indicators of oxidative stress, and the increase of MDA level in diabetic patients is caused by the peroxidative decomposition of phospholipids caused by free oxygen radicals (29).…”

Section: Discussionmentioning

confidence: 99%

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Dong

2019

Exp Ther Med

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Correlation between expression levels of advanced glycation end products (AGEs) and adipocytokines and oxidative stress index malondialdehyde (MDA) in placental tissues of pregnant women with gestational diabetes mellitus (GDM) was investigated. Seventy-two cases of GDM pregnant women who received routine prenatal examination and gave birth in the Department of Obstetrics, Binzhou City Center Hospital from March 2016 to May 2017 were collected as the observation group. Another 80 cases of normal pregnant women who gave birth at the same time were selected as the control group. Enzyme linked immunosorbent assay (ELISA) was used to detect the expression levels of AGEs, visfatin, APN and IL-6 in the lysate of placental tissues. MDA levels were measured by thiobarbituric acid method. Correlation of expression levels of AGEs, visfatin, APN, IL-6 and MDA were analyzed. The expression level of MDA in placental tissues of the observation group was significantly higher than that of the control group (t=16.44, P<0.001). The correlation of expression levels between AGEs, adipocytokines and MDA in placental tissues of the two groups was analyzed, and it was found that the expression levels of AGEs, visfatin and IL-6 in the two groups were positively correlated with MDA. There was a significantly negative correlation between APN and MDA in the two groups. The incidence of cesarean section, neonatal hypoglycemia, fetal distress and macrosomia in the observation group was significantly higher than that in the control group (P<0.05). There was no significant difference in the incidence of membrane rupture and premature birth between the two groups (P>0.05). In conclusion, the expression levels of AGEs, visfatin and IL-6 in placental tissues of GDM pregnant women are positively correlated with MDA. There is a significant negative correlation between APN and MDA, and they play an important role in the pathogenesis of GDM.

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Section: Discussionmentioning

confidence: 99%

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Dong

2019

Exp Ther Med

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“…A 33-year-old woman with a diagnosis of diabetic ketoacidosis, LADA, and sepsis caused by bronchopneumonia was treated. The problem with this patient is whether this patient is type 2 DM or another type of DM, given that clinically type 2 DM and other types of DM can be found in young adults [3], [4].…”

Section: Discussionmentioning

confidence: 99%

“…Symptoms of LADA are similar to Type 1 diabetes but are found in adulthood. The slow progression of pancreatic β cell damage in LADA is initially almost always diagnosed as type 2 diabetes mellitus [4], [5].…”

Section: Introductionmentioning

confidence: 99%

Sepsis in Latent Autoimmune Diabetes in Adults with Diabetic Ketoacidosis: A Case Report

Rahmadi¹,

Decroli²,

Kam³

2019

Open Access Maced J Med Sci

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BACKGROUND: This case report intends to highlight the challenge in diagnosing type 1 diabetes on an adult patient. Latent Autoimmune Diabetes in Adult (LADA) types I diabetes Mellitus, which found in adulthood and characterised by progressive damage to pancreatic β cells that happened slowly. Incidence of LADA is around 2-12% of the total diabetes population. Sepsis in LADA patients will trigger diabetic ketoacidosis (DKA). CASE REPORT: We report a case of a 33-year-old woman patient presents with decreased consciousness accompanied by rapid and deep breathlessness for 1 day. Before, the patient complains of fever and cough. Physical examination found soporous, blood pressure 120/80 mmHg, pulse 110 x/minute, temperature 38.8°C, breathing 32 x/minute Kussmaul. Bronchovesicular breath crackles in both lower lung fields. leukocytes were 22,100/mm3, random blood glucose 638 mg/dL, urine ketone +++, HbA1C 17.2%, HOMA IR less than 2 units. C-peptide 0.3 ng/mL and GADAs 16.9 U/mL. Chest Xray indicated bronchopneumonia. Patients were diagnosed with diabetic ketoacidosis, LADA, and sepsis caused by bronchopneumonia. Patient treated with DKA management and sepsis. On the second day, the treatment of DKA was resolved and continued with the administration of short-acting insulin and regular long-acting. CONCLUSION: Sepsis in LADA with DKA requires fast and appropriate management. Further search is needed to diagnose LADA.

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“…NGF plays a key role in the neuronal development and function of both central and peripheral nervous system [ 62 ]. Lower concentrations of NGF are connected to reduced values of nerve conduction velocity, which is a fundamental player of the pathogenesis of DP [ 63 ].…”

Section: C-reactive Proteinmentioning

confidence: 99%

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

Siwik

Gajewska

Jaguszewski

et al. 2020

JCM

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Diabetes mellitus (DM) is a common disease worldwide. There is a strong association between DM and neurovascular and neurodegenerative disorders. The first group mainly consists of diabetic retinopathy, diabetic neuropathy and stroke, whereas, the second group includes Alzheimer’s disease, Parkinson’s disease, mild cognitive impairment and dementia. The aforementioned diseases have a common pathophysiological background including insulin resistance, oxidative stress, atherosclerosis and vascular injury. The increasing prevalence of neurovascular and neurodegenerative disorders among diabetic patients has resulted in an urgent need to develop biomarkers for their prediction and/or early detection. The aim of this review is to present the potential application of the most promising biomarkers of diabetes-related neurodegenerative and neurovascular disorders, including amylin, β-amyloid, C-reactive protein (CRP), dopamine, gamma-glutamyl transferase (GGT), glycogen synthase kinase 3β, homocysteine, microRNAs (mi-RNAs), paraoxonase 1, phosphoinositide 3-kinases, tau protein and various growth factors. The most clinically promising biomarkers of neurovascular and neurodegenerative complications in DM are hsCRP, GGT, homocysteine and miRNAs. However, all biomarkers discussed in this review could become a part of the potential multi-biomarker screening panel for diabetic patients at risk of neurovascular and neurodegenerative complications.

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The Correlation between Malondialdehyde and Nerve Growth Factor Serum Level with Diabetic Peripheral Neuropathy Score

Cited by 18 publications

References 21 publications

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Advanced glycation end products and adipocytokines and oxidative stress in placental tissues of pregnant women with gestational diabetes mellitus

Sepsis in Latent Autoimmune Diabetes in Adults with Diabetic Ketoacidosis: A Case Report

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

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