The correlation between maternal hypomagnesemia and preterm labour

Mahmoud, Shatha A.; Saleh, Ikhlas Mansour; Khalaf, Huda H.

doi:10.18203/2320-1770.ijrcog20162624

Cited by 7 publications

(22 citation statements)

References 16 publications

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“…This result is in accordance with the studies of Mahmoud et al, and Khani et al, who also reported that 85% and 90% patients with preterm labour were housewives. 8,10 In the present study, 70%, 22% and 8% patients with preterm labour and 55%, 32% and 13% with term labour belonged to low, middle and high socioeconomic class respectively, the difference being statistically significant (p=0.04). Bhat et al, found patients with preterm labour belonging to low socioeconomic class were significantly higher than the middle and higher socioeconomic classes (58% in preterm labour patients and 45% in term, p<0.05).…”

Section: Discussionsupporting

confidence: 41%

“…9 The mean maternal age in our study (24.96 years for preterm group and 25.04 years for term group) was consistent with the studies of Mahmoud et al, (24.31 versus 26.52 years) and Jenabi et al, (24.56 vs. 25.18 years). 8,9 However, it was lower in preterm group as compared to study conducted by Bhat et al, (28.63 years). 7 The difference can be explained due to early age of marriage and lesser use of contraceptives methods in our study.…”

Section: Discussionmentioning

confidence: 62%

“…7 Mahmoud et al, found that patients with preterm labour had significantly reduced serum magnesium level (mean 1.55mg/dL versus 1.81mg/dL) for those who delivered at term (p<0.032). 8 Jenabi et al, also found positive association between maternal serum magnesium levels and preterm labour. 9 The mean maternal age in our study (24.96 years for preterm group and 25.04 years for term group) was consistent with the studies of Mahmoud et al, (24.31 versus 26.52 years) and Jenabi et al, (24.56 vs. 25.18 years).…”

Section: Discussionmentioning

confidence: 91%

“…7 Mahmoud et al, also found that in preterm labour group lower socioeconomic class was significantly higher than the middle and upper socioeconomic classes. 8 Patients belonging to low socioeconomic classes have stressful lifestyle, inaccessible medical care and diet deficient in micronutrients including magnesium.…”

Section: Discussionmentioning

confidence: 99%

“…Our findings were similar to the observations of Bhat et al, Mahmoud et al, and Shaikh et al, who reported percentage of patients with preterm labour having history of muscle cramps as 89%, 73% and 46.7% respectively. [7][8][9] Neuromuscular hyperexcitability is an initial problem cited in individuals who have magnesium deficiency resulting in muscle cramps and uterine hyperactivity leading to premature onset of labour. 13 In our study low birth weight neonates were significantly more in patients with preterm labour with percentage of 60% and 11% in patients with term labour.…”

Section: Discussionmentioning

confidence: 99%

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The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

Anand¹,

Hak²,

Prashar³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: Serum magnesium level in pregnancy is a valuable tool to find out preterm onset of labour. In the asymptomatic group, greater surveillance and administration of steroids, tocolytics and transfer to a higher centre wherever necessary has to be done with mothers with low serum magnesium level. The objective of the study is to find association between serum magnesium levels and women with preterm labour, and to compare these values with those patients who have a term delivery.Methods: The subjects included 100 pregnant women with preterm labour (cases) between 28 and 37 weeks gestation (Group A) and similar number of pregnant women with term labour (controls) between 37 and 40 weeks (Group B). Inclusion criteria for cases was singleton pregnancy, painful uterine contractions more than two in 30 minutes, intact fetal membranes, cervical dilatation (at least 1 cm) and effacement (80%). Serum magnesium levels were done in both the groups. Patients were followed until delivery. Routine antenatal investigations were done. Serum levels of magnesium were estimated by Erba’s semi auto-analyser.Results: 62% patients in Group A were from rural areas. More patients in Group A (70%) were from low socioeconomic class. More women in Group A were anaemic (44%). Mean value of hemoglobin in Group A was 9.93gm/dL. More patients in Group A had muscle cramps (89%). VLBW (<1500gm) neonates were more in Group A (21%). Also, LBW (1500-2499gm) neonates were more in Group A (60%). Mean neonatal birth weight in Group A (1907.3gm) was less. Neonatal morbidity and mortality was observed significantly more in Group A. Mean serum magnesium was less in Group A. Mean serum magnesium levels in primi and multigravida patients were less in Group A. Moreover, mean serum magnesium levels were less in urban and rural patients in Group A. Mean serum magnesium levels were less in normal and overweight patients in Group A. Also, mean serum magnesium levels were less in patients with cervical dilatation <3cm and >3cm in Group A.Conclusions: Low maternal serum magnesium level is associated with preterm labour. Patients with preterm labour have significantly low serum magnesium level when compared with labour at term.

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Section: Discussionsupporting

confidence: 41%

Section: Discussionmentioning

confidence: 62%

Section: Discussionmentioning

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

Anand¹,

Hak²,

Prashar³

et al. 2019

Int J Reprod Contracept Obstet Gynecol

View full text Add to dashboard Cite

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Intrapartum Hypomagnesemic Tetany: A Manifestation of an Ignored Element

Doctor

Bathija

Pardasani

2018

J Obstet Gynecol India

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Magnesium levels in relation to rates of preterm birth: a systematic review and meta-analysis of ecological, observational, and interventional studies

et al. 2020

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Context Experimental studies suggest that magnesium levels in pregnant women may affect the length of gestation, as magnesium affects the activity of smooth muscle in the uterus. Little is known about the association between magnesium levels or supplementation and the rate of preterm birth. Objective The aim of this systematic review was to summarize the data on magnesium soil levels and preterm birth rates from ecological, observational, and interventional studies. Data Sources Soil magnesium levels were obtained from US Geological Survey data, and preterm birth rates were acquired from the March of Dimes Foundation. Relevant epidemiological and clinical studies published until April 2019 in peer-reviewed journals were retrieved from PubMed, Google Scholar, and related reference lists. Study Selection Original studies published in English, conducted in humans, and in which magnesium (dietary/supplemental intake or biomarkers) was an exposure and preterm birth was an outcome were included. Data Extraction Eleven studies were included in the systematic review. Meta-analysis was performed on 6 studies. Overall relative risk (RR) and corresponding 95%CIs for risk of preterm birth in relation to magnesium supplementation were estimated by a random-effects model. Results The ecological study revealed an inverse correlation between magnesium content in soil and rates of preterm birth across the United States (r = −0.68; P < 0.001). Findings from 11 observational studies generally support an inverse association between serum magnesium levels and rates of preterm birth. Of the 6 eligible randomized controlled trials, which included 3068 pregnant women aged 20 to 35 years and 352 preterm infants, the pooled RR was 0.58 (95%CI, 0.35–0.96) for women in the magnesium supplementation group compared with women in the control group. Conclusions Accumulated evidence from ecological, observational, and interventional studies consistently indicates that adequate magnesium intake during pregnancy may help reduce the incidence of preterm birth.

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The correlation between maternal hypomagnesemia and preterm labour

Cited by 7 publications

References 16 publications

The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

The study of association between maternal serum magnesium levels and preterm labour in a tertiary care hospital

Intrapartum Hypomagnesemic Tetany: A Manifestation of an Ignored Element

Magnesium levels in relation to rates of preterm birth: a systematic review and meta-analysis of ecological, observational, and interventional studies

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