The correlation between morphology and implantation of euploid human blastocysts

Nazem, T.G.; Sekhon, L.; Lee, Joseph A.; Overbey, Jessica; Pan, Stephanie; Duke, M.; Briton-Jones, Christine; Whitehouse, M.C.; Copperman, A.B.; Stein, Daniel E.

doi:10.1016/j.rbmo.2018.10.007

Cited by 44 publications

(24 citation statements)

References 19 publications

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“…Most previous studies only analyzed the relationship between individual morphological parameters and pregnancy outcomes [1,8,21]. To date, only a limited number of studies have comprehensively evaluated the mixed effects of multiple parameters on pregnancy outcomes [22]. We combined the morphological qualities into an assessment and calculated LBR for each combination of morphology grades.…”

Section: Discussionmentioning

confidence: 99%

Association between blastocyst morphology and live birth rate following frozen–thawed single blastocyst transfer: Results from a 5‐year retrospective analysis of 2593 cryopreserved blastocysts

Guo

Deng

Jiang

et al. 2020

J of Obstet and Gynaecol

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Aim: Our aim was to investigate associations between blastocyst morphology parameters and live birth outcome and to make possible additional recommendations for existing embryo selection strategies. Methods: This retrospective cohort study included 2593 frozen-thawed single blastocyst transfers (SBT) cycles from 2012 to 2016. Multivariable logistic regression model was used to analyze the independent predictive effectiveness of blastocyst parameters for live birth rate (LBR). Results: The participants enrolled in the present study were 32 (28-35) years old with a median body mass index of 21.20 (19.60-23.40) kg/m 2 , among whom 1058 (40.8%) women had live births. Among the three blastocyst morphology parameters, we found only inner cell mass grade and trophectoderm cell grade had significant effects on LBR (P < 0.001). When adjusting for potential confounders in a multivariable logistic regression model, the expansion and hatching (EH) stage of blastocoel also showed obvious correlation with LBR. Blastocysts at EH stage 4-5 had a significantly higher LBR than that at stage 3 (P < 0.05). Additionally, the timing of blastulation was also an important predictor of LBR. Blastocysts vitrified on day 6 and day 7 yielded a lower LBR than that vitrified on day 5 (P < 0.001). Conclusion: The timing of blastulation and all blastocyst morphology parameters were associated with LBR independently. Although the most important parameter for predicting clinical outcomes remains undetermined, the timing of blastulation was a stable predictor of live birth for frozen-thawed SBT.

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Section: Discussionmentioning

confidence: 99%

Association between blastocyst morphology and live birth rate following frozen–thawed single blastocyst transfer: Results from a 5‐year retrospective analysis of 2593 cryopreserved blastocysts

Guo

Deng

Jiang

et al. 2020

J of Obstet and Gynaecol

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“…We hope that Irani and colleagues, as well as researchers at other centers with large data, could consider the previously mentioned issues and further verify the effect of expansion grade on pregnancy outcomes proposed by Nazem et al 2 In addition, Irani et al 1 concluded that differences in spontaneous abortion at different ages were not statistically significant, but older women (>40 years) still showed an increasing trend that should not be ignored. In addition, euploid embryo transfer can help older women achieve live birth rates that are similar to those of younger women; however, this does not mean that their pregnancy qualities are comparable.…”

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confidence: 81%

“…We further analyzed the trophectoderm grade of A and B in this paper of Nazem et al 2 and found no statistically significant difference in any of the results between the 2 grades (P > .05; SPSS version 20.0). The abovementioned points indicate that it may be unreasonable to include AB and BA in the same group.…”

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confidence: 82%

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In women with transplantable euploid blastocysts, age does not affect transplant potential

Guo

Zhang

2019

American Journal of Obstetrics and Gynecology

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“…Oocytes were fertilized by conventional insemination or intracytoplasmic sperm injection approximately 4 hours after retrieval. All embryos were cultured up to blastocyst stage as described previously . Day‐5 embryos were transferred in a fresh cycle with luteal support by vaginal and/or intramuscular progesterone.…”

Section: Methodsmentioning

confidence: 83%

Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success

Hernández-Nieto

Lee

Gonzalez

et al. 2019

Intl J Gynecology & Obste

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Objective:To analyze outcomes of IVF treatment among women diagnosed with an ovarian dermoid cyst (DC).Methods: Retrospective analysis of women with an ovarian DC who underwent IVF with fresh blastocyst transfer at a single center in New York from January 2010 to March 2018. Outcomes were compared between women with conservative treatment and those with surgical excision of the DC. Multivariate logistic regression was used to assess associations between variables and the presence of a DC during treatment. Results:Overall, 119 women with a DC were included. No differences were found in demographic characteristics, controlled ovarian hyperstimulation parameters, and IVF outcomes between women with an intact DC (n=65, 54.6%) and those who underwent cystectomy (n=54, 45.4%) (all P<0.05). Similarly, there was no difference in anti-Mϋllerian hormone and basal antral follicle count among women with a DC (respectively, β=−0.1, P=0.8, and β=−1.0, P=0.28) or resected DC (respectively, β=0.9, P=0.07, and β=1.5, P=0.08) as compared with control women with no DC (n=352). Conclusion:Ovarian reserve, embryo implantation and IVF success rates were not lower in the presence of an ovarian DC. Surgical therapy, if indicated, can be safely postponed until family planning goals have been achieved. K E Y W O R D S

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The correlation between morphology and implantation of euploid human blastocysts

Cited by 44 publications

References 19 publications

Association between blastocyst morphology and live birth rate following frozen–thawed single blastocyst transfer: Results from a 5‐year retrospective analysis of 2593 cryopreserved blastocysts

Association between blastocyst morphology and live birth rate following frozen–thawed single blastocyst transfer: Results from a 5‐year retrospective analysis of 2593 cryopreserved blastocysts

In women with transplantable euploid blastocysts, age does not affect transplant potential

Conservative treatment versus surgical excision of ovarian dermoid cysts: Impact on ovarian stimulation and IVF cycle success

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