The correlation between the metabolic tumor volume and hematological parameters in patients with esophageal cancer

Sürücü, Erdem; Demir, Yusuf; Şengöz, Tarık

doi:10.1007/s12149-015-1020-4

Cited by 19 publications

(16 citation statements)

References 25 publications

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“…A weak but statistically significant correlation was found between SUVmax and NLR. Furthermore, several studies have demonstrated a direct association between metabolic tumor volume (MTV) and NLR [34][35][36]. In our present study, we determined that SUVmean also had a positive correlation with NLR.…”

Section: Discussionsupporting

confidence: 51%

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

Wang

Zhao

et al. 2020

BMC Cancer

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Background: We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcinoma (ESCC) after concurrent chemoradiotherapy (CCRT). Methods: We retrospectively analyzed 163 newly diagnosed ESCC patients treated with CCRT. Eighty patients (training set) were randomly selected to generate cutoff SUVmean and NLR values by receiver operating characteristic (ROC) curve analysis and to establish a predictive model by using the independent predictors of treatment outcomes. Then, we evaluated the performance of the prediction model regarding treatment outcomes in the testing set (n = 83) and in all sets. Results: A high SUVmean (> 5.81) and high NLR (> 2.42) at diagnosis were associated with unfavorable treatment outcomes in patients with ESCC. The prediction model had a better performance than the simple parameters (p < 0.05). With a cutoff value of 0.77, the prediction model significantly improved the specificity and positive predictive value for treatment response (88.9 and 92.1% in the training set, 95.8 and 97.1% in the testing set, and 92.2 and 91.8% in all sets, respectively). Conclusions: The pretreatment SUVmean and NLR were independent predictors of treatment response in ESCC patients treated with CCRT. The predictive model was constructed based on these two parameters and provides a highly accurate tool for predicting patient outcomes.

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Section: Discussionsupporting

confidence: 51%

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

Wang

Zhao

et al. 2020

BMC Cancer

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“…If such correlations exist, PET parameters and hematological parameters may provide complementary information that could be combined for prognosis assessment. To the best of our knowledge, while several reports (21,22) have explored how PET parameters are correlated with NLR and PLR, no reports have addressed this topic for LACC. Therefore, this study was conducted for the following purposes: (I) to compare the values of SUV max , MTV, and TLG of the primary tumor (SUV max -P, MTV-P, and TLG-P, respectively) and the combination of the primary tumor and SMLNs (SUV max -C, MTV-C, and TLG-C, respectively) based on different percentages of SUV max (%SUV max ) thresholds for evaluating tumor recurrence and find the optimal PET parameter; (II) to investigate correlations between PET parameters and hematological parameters to determine the most relevant PET parameters and optimal thresholds; (III) and to explore independent risk factors affecting recurrence-free survival (RFS) for LACC.…”

Section: Introductionmentioning

confidence: 99%

Metabolic parameters with different thresholds for evaluating tumor recurrence and their correlations with hematological parameters in locally advanced squamous cell cervical carcinoma: an observational 18F-FDG PET/CT study

Sun

Gao

et al. 2019

Quant. Imaging Med. Surg

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Background: Positron emission tomography (PET) parameters for a combination of the primary tumor and suspicious metastatic lymph nodes (SMLNs) appear to be more potential than those for the primary tumor alone for evaluating tumor recurrence in locally advanced cervical carcinoma (LACC), while the optimal threshold has not been determined. This study investigated the optimal PET parameters and percentage of SUV max (%SUV max ) thresholds for tumor recurrence evaluation, and the relationship with hematological parameters in patients with LACC treated with concurrent chemoradiotherapy (CCRT).Methods: Eighty-nine patients with advanced squamous cell cervical carcinoma (SCCC) scheduled for CCRT underwent pretreatment whole body PET/CT scans. We analyzed PET parameters including maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) of the primary tumor (SUV max -P, MTV-P, TLG-P) and the combination of the primary tumor and SMLNs (SUV max -C, MTV-C, TLG-C). The association between PET parameters with different %SUV max threshold and recurrence-free survival (RFS), and the correlations between PET parameters and hematological parameters including squamous cell carcinoma antigen (SCC-ag), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and hemoglobin (Hb) were evaluated. Results:The optimal threshold for evaluating tumor recurrence was 50%SUV max , and the optimal PET parameter was MTV-C with the 50%SUV max threshold (MTV-C 50% ) (c-index =0.752). Multivariate analysis indicated that MTV-C 50% [hazard ratio (HR), 1.065; P<0.001], NLR (HR, 1.195; P=0.045) and SMLNs (HR, 2.225; P=0.003) were independent risk factors for RFS. MTV and TLG with most of %SUV max thresholds had slight-to-moderate correlations with SCC-ag, NLR and PLR. For SCC-ag, MTV-C55% (r=0.500; P<0.001) had the highest correlation coefficient among all parameters. For NLR and PLR, MTV-C 50% (r=0.637 and r=0.515, respectively; P<0.001 for both correlations) received the highest correlation coefficient. Conclusions:The MTV-C estimated by using a 50%SUV max threshold, which is related to systemic inflammatory response biomarker (NLR and PLR), can be used as an optimal PET parameter associated with tumor recurrence of LACC.

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“…Several markers in the complete blood counts including the neutrophil-tolymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and mean platelet volume (MPV) have been studied in several cancer types and inflammatory conditions [6,7,11,12]. The NLR has been significantly correlated with the size of tumor and higher NLR may imply a poorer tumor profile in well-DTC [13,14].…”

Section: Introductionmentioning

confidence: 99%

Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy

Demir

Üçler

Sürücü

et al. 2016

Nuclear Medicine Communications

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The correlation between the metabolic tumor volume and hematological parameters in patients with esophageal cancer

Abstract: At baseline neutrophil-to-lymphocyte ratio is associated with the metabolic tumor volume, which was assessed using the PET/CT in patients with esophageal squamous cell cancer. The SUVmax values were not related to these parameters.

Cited by 19 publications

References 25 publications

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

A predictive model for treatment response in patients with locally advanced esophageal squamous cell carcinoma after concurrent chemoradiotherapy: based on SUVmean and NLR

Metabolic parameters with different thresholds for evaluating tumor recurrence and their correlations with hematological parameters in locally advanced squamous cell cervical carcinoma: an observational 18F-FDG PET/CT study

Temporary changes in neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios, and mean platelet volume reflecting the inflammatory process after radioiodine therapy

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