The Correlation of Laboratory Tests and Sympathetic Skin Response Parameters by Using Artificial Neural Networks in Fibromyalgia Patients

Abstract

Fibromyalgia syndrome (FMS) is a chronic musculoskeletal disease which causes dysfunction of the autonomic nervous system. Sympathetic Skin Response (SSR) is a part of electrical impedance of body which is affected by the autonomic nervous system dysfunctions. In this study, values obtained from the results of the patients diagnosed with fibromyalgia syndrome, and healthy subjects blood samples in the laboratory conditions are recorded in Suleyman Demirel University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation. SSR measurements are recorded from patients and healthy controls. Values of latency time, maximum amplitude and elapsed time between two stimulus parameters are obtained from recorded sympathetic skin response data by using Matlab software. The relationship between SSR parameters and laboratory tests is investigated by using artificial neural networks. As a result SSR seems to be a valid parameter in the classification of FMS.

A Systematic Review and Meta-Analysis of the Prevalence of Small Fibre Impairment in Patients with Fibromyalgia

“…Seven studies tested autonomic small fibres using sympathetic skin response. Of these seven studies, three did not find significant differences between patients and healthy controls [41,78,80], while three studies found significantly prolonged sympathetic skin response latencies in patients with fibromyalgia [38,79,81], and two studies found a significantly reduced sympathetic skin response amplitude in patients with fibromyalgia, as compared with healthy controls [79,82]. Two studies [38,82] respectively provided an 18% and 39% estimated frequency of autonomic dysfunction with sympathetic skin response.…”

“…Seven studies investigated skin conductance [40,[72][73][74][75][76][77] and seven investigated sympathetic skin response [38,41,[78][79][80][81][82]. Four showed that patients with fibromyalgia had reduced baseline skin conductance, as compared with healthy controls [40,[72][73][74], while two studies [75,76] found no significant differences, and one study found higher conductance levels in patients with fibromyalgia [77].…”

Sympathetic Skin Response: A New Biological Signal that can be used in Diagnosis of Fibromyalgia Instead of Beck Depression Inventory

“…Al. in 2012, the relationship between FMS and SSR was examined in detail and it was stated that SSR could be used in diagnosing FMS [3], [5], [18], [19].…”

Investigating the Effect of Sympathetic Skin Response Parameters on the Psychological Test Scores in Patients with Fibromyalgia Syndrome by Using ANNS

“…SSR which a part of electrical impedance of the body is defined by arising spontaneously depending on the body's internal dynamics or by means of a stimulus is applied externally to the body as a reflex that can occur temporary electrical potential difference in the skin [5]. Although the SSR parameters that affect in the human body is unknown exactly in many studies, investigation the sympathetic nervous system function of SSR may be a non-invasive approach have been proposed [6][7][8]. Measurements of SSR is easy, but they are not be safe enough for diagnostic applications when valid procedures are taken into account and autonomic and sudomotor function disorders in particular are not found an absolute accuracy relationship between the obtained clinical findings and the measurements of SSR [7,8].…”

“…SSR is an instantaneous and nonpersistent change given by the internal and/or external stimulus in the electrical potential of the skin of palm and sole [5]. Studies shows that latency time obtained from SSR data of patients with FMS has been affected dysfunction in the autonomic nervous system [5,6]. FMS also significantly affects the autonomic nervous system, a relationship between the SSR and FMS is clear.…”