The correlation of serum eosinophil cationic protein level with eosinophil count, and total IgE level in Korean adult allergic rhinitis patients

Abstract

Background: Eosinophil cationic protein (ECP) is present in eosinophil granules. It has been associated with eosinophil-associated disorders. Objective: We compared serum ECP levels in allergic and non-allergic rhinitis patients and evaluated the association with the eosinophil count and the total IgE level. Method: We retrospectively reviewed medical records and categorized enrolled patients into the allergic (AR) and non-allergic rhinitis (NAR) groups. ECP, eosinophil count, and total IgE levels were reviewed in both groups. The association between ECP and the eosinophil count and total IgE level was further evaluated according to commonly detected specific antigens. Results: Six hundred and ten adults were included in the study. In the AR group (n=349), the median age was 27.0 (23.0-42.0) years and the female:male ratio was 0.26:1. In the NAR group (n=261), the median age was 32.0(24.0-45.5) years and the female:male ratio was 0.33:1.

The role of cationic protein in respiratory allergies in children

“…Доминирующим мнением на сегодняшний день является убеждение, что достоверным маркером аллергического воспаления можно считать повышение уровня эозинофилов как в крови, так и в назальном секрете [1]. КПЭ при этом является объективным маркером активации эозинофилов и составляет 70 % от всех белков, продуцируемых эозинофилами [2,3]. Синтез КПЭ в основном осуществляется тканевыми эозинофилами и запускается уже на стадии образования промиелоцитов.…”