The Crosstalk Between Long Non-Coding RNAs and Various Types of Death in Cancer Cells

Abstract

With the increasing aging population, cancer has become one of the leading causes of death worldwide, and the number of cancer cases and deaths is only anticipated to grow further. Long non-coding RNAs (lncRNAs), which are closely associated with the expression level of downstream genes and various types of bioactivity, are regarded as one of the key regulators of cancer cell proliferation and death. Cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, plays a vital role in the progression of cancer. A better understanding of the regulatory relationships between lncRNAs and these various types of cancer cell death is therefore urgently required. The occurrence and development of tumors can be controlled by increasing or decreasing the expression of lncRNAs, a method which confers broad prospects for cancer treatment. Therefore, it is urgent for us to understand the influence of lncRNAs on the development of different modes of tumor death, and to evaluate whether lncRNAs have the potential to be used as biological targets for inducing cell death and predicting prognosis and recurrence of chemotherapy. The purpose of this review is to provide an overview of the various forms of cancer cell death, including apoptosis, necrosis, autophagy, pyroptosis, and ferroptosis, and to describe the mechanisms of different types of cancer cell death that are regulated by lncRNAs in order to explore potential targets for cancer therapy.

Systematic discrimination of the repetitive genome in proximity of ferroptosis genes and a novel prognostic signature correlating with the oncogenic lncRNA CRNDE in multiple myeloma

“…Since an increasing number of studies have indicated that non-coding RNAs may modulate the process of ferroptotic cell death ( 43 – 45 ). Herein, we also assessed the potential correlation of obtained ferroptosis gene signature with the lncRNAs.…”

Ferroptosis in tumors and its relationship to other programmed cell death: role of non-coding RNAs

“…Recent studies have revealed that hippocampal calmodulin-like 1 (HPCAL1) is an autophagy receptor that affects membrane tension by regulating CDH2, which further affects lipid peroxidation and ultimately inhibits ferroptosis in vitro and in vivo [ 88 ]. Another autophagy receptor, Tax1 (human T cell leukemia virus type I) binding protein 1 (TAX1BP1), promotes GPX4 degradation and subsequent ferroptosis in response to copper stress [ 89 ]. The above studies suggest a close association between autophagy and ferroptosis.…”

An Overview of the Immune Modulatory Properties of Long Non-Coding RNAs and Their Potential Use as Therapeutic Targets in Cancer

“…The role of ncRNAs in tumorigenesis and immune response has been investigated widely in cancers. In these settings, ncRNAs regulate proliferation, differentiation, apoptosis, necrosis, autophagy, immune response, and inflammation [35,69,83,84]. In colorectal cancer, it was reported that the tumor suppressor miR-195-5p promotes TAM polarization by suppressing NOTCH2 expression [85].…”