The crucial role of prolactin-lactogenic hormone in Covid-19

Al-Kuraishy, Hayder M; Al-Gareeb, Ali I; Butnariu, Monica; Batiha, Gaber El‐Saber

doi:10.1007/s11010-022-04381-9

Cited by 36 publications

(56 citation statements)

References 100 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical evidence supports the role of some molecules revealed in this work in COVID-19 pathogenesis: ANGPT2 [48,49], CCL2 [50], ICAM1 [52,53], VCAM-1 [52], MIR21 [54], MMP9 [55,56], STAT3 [57], HMGB1 [58,59], SIRT1 [62,63], AGTR1 [66], APOE4 [69,70], ACE [73], CCL11 [86,87], FGF2 [89], TNF [92], PPAR-γ [95], CASP8 [115], IL8 [117], IL6 [118], PRL [119], SP1 [122], TLR4 [123], BDNF [124], CASP1 [125], CASP3 [126,127], IL18 [128], IL10 [129], TGFB1 [130], ANXA2 [131,132], HPSE [162], MAPK1 [163], CDH1 [166], FBN1 [180], GDF15 [182,183], PLAT [195][196][197], RHOA…”

Section: Discussionsupporting

confidence: 80%

“…Interleukin-6 was proposed as a biomarker for the development of fatal severe acute respiratory syndrome in COVID-19 [118]. It was reported that prolactin serum levels are increased in COVID-19 patients [119]. Cathepsin B stimulates prolactin release [120].…”

Section: Ctsb-related Networkmentioning

confidence: 99%

“…The excess of prolactin can contribute to hyperglycemia by the reduction of insulin sensitivity [121]. On the other hand, prolactin may reduce the hyperinflammatory status in COVID-19 as it has an antiinflammatory activity [119]. The Sp1 transcription factor could be linked with cytokine expression and the inflammatory response in COVID-19 via miR-155-5p [122].…”

Section: Ctsb-related Networkmentioning

confidence: 99%

See 2 more Smart Citations

Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

Saik

Климонтов

2022

IJMS

View full text Add to dashboard Cite

People with diabetes are more likely to have severe COVID-19 compared to the general population. Moreover, diabetes and COVID-19 demonstrate a certain parallelism in the mechanisms and organ damage. In this work, we applied bioinformatics analysis of associative molecular networks to identify key molecules and pathophysiological processes that determine SARS-CoV-2-induced disorders in patients with diabetes. Using text-mining-based approaches and ANDSystem as a bioinformatics tool, we reconstructed and matched networks related to hyperglycemia, diabetic complications, insulin resistance, and beta cell dysfunction with networks of SARS-CoV-2-targeted proteins. The latter included SARS-CoV-2 entry receptors (ACE2 and DPP4), SARS-CoV-2 entry associated proteases (TMPRSS2, CTSB, and CTSL), and 332 human intracellular proteins interacting with SARS-CoV-2. A number of genes/proteins targeted by SARS-CoV-2 (ACE2, BRD2, COMT, CTSB, CTSL, DNMT1, DPP4, ERP44, F2RL1, GDF15, GPX1, HDAC2, HMOX1, HYOU1, IDE, LOX, NUTF2, PCNT, PLAT, RAB10, RHOA, SCARB1, and SELENOS) were found in the networks of vascular diabetic complications and insulin resistance. According to the Gene Ontology enrichment analysis, the defined molecules are involved in the response to hypoxia, reactive oxygen species metabolism, immune and inflammatory response, regulation of angiogenesis, platelet degranulation, and other processes. The results expand the understanding of the molecular basis of diabetes and COVID-19 comorbidity.

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Ctsb-related Networkmentioning

confidence: 99%

Section: Ctsb-related Networkmentioning

confidence: 99%

See 1 more Smart Citation

Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

Saik

Климонтов

2022

IJMS

View full text Add to dashboard Cite

show abstract

“…The results of the measurement of serum prolactin levels were the highest at 315.4 ng/mL and the lowest at 21.1 ng/mL. The variation in results that experienced significant differences could be influenced by several factors, namely exercise and a high-protein diet between breastfeeding mothers [27] [28].…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Genistein Intake and Body Mass Index (BMI) with Serum Prolactin Levels in Breastfeeding Women in the Area of Benowo and Kenjeran Public Health Centers

Rahardjo¹,

Wardani²,

Lestari³

et al. 2022

PJMHS

View full text Add to dashboard Cite

Mother's milk is considered the optimal substance for newborns because it provides complete nutrition, improves infant health, and increases immunity and low incidence of gastrointestinal disease. The development of the alveolar-lobular glands in the breast for the initiation of breastfeeding is the role of the prolactin hormone. Genistein is a type of isoflavonoid whose content is abundant in soybeans, and their processed products (tempeh and tofu) play a role in the synthesis of serum prolactin. Body Mass Index (BMI) indicates maternal nutritional status, which can also affect serum prolactin. This study will discuss the relationship between genistein intake and BMI on serum prolactin levels of nursing mothers. This research uses analytical observational research on 110 breastfeeding mothers in the Benowo and Kenjeran Health Center Work Areas, Surabaya. The results of Spearman's correlation test showed that there was a significant relationship between genistein intake on maternal serum prolactin levels (p=0.001) and BMI on maternal serum prolactin levels (p=0.036) (Pearson's test). The estrogenic properties of genistein are very similar to endogenous estrogens, which are thought to increase the formation of maternal serum prolactin levels and its activity which stimulated ductal elongation in mammary gland development. The increase in BMI levels in the body is go with an increase in serum prolactin levels due to the lack of availability of dopamine two receptor (D2R) sites in the body of nursing mothers. Keywords: Genistein intake Body Mass Index, Serum Prolactin Levels Exclusive breastfeeding Nutrition of breastfeeding mothers

show abstract

“… 44 Similarly, high AngII in COVID-19 due to downregulation of ACE2 also activates MAPK leading to severe complications. 45 Taken together, high AngII and activated MAPK may interfere with the erythrocrine function of erythrocyte anti-inflammatory actions with reduction of erythrocyte NO and subsequent endothelial dysfunction. These changes induce abnormal erythrocyte function with the development of extracellular vesicles, which stimulate MAPK and NF-κB with subsequent development of cytokine storm.…”

Section: Introductionmentioning

confidence: 99%

COVID-19 and erythrocrine function: The roller coaster and danger

Al-Kuraishy

Al-Gareeb

Onohuean

et al. 2022

Int J Immunopathol Pharmacol

View full text Add to dashboard Cite

Erythrocrine function refers to erythrocytes’ ability to synthesize and release active signaling molecules such as ATP and nitric oxide (NO). Erythrocyte NO regulates its deformability and increases its perfusion and circulation that prevent tissue hypoxia. Recently, there is a connotation between SARS-CoV-2 infection and erythrocrine function due to alteration in the release of NO and ATP from erythrocytes. SARS-CoV-2 binds erythrocyte band3 protein, which has a similar characteristic of ACE2, leading to alteration of erythrocyte physiology like oxygen transport with development of hypoxia. Similarly, SARS-CoV-2 infection activates erythrocyte protein kinase C alpha (PKC-α), causing significant changes in the erythrocyte functions. The erythrocytes can bind SARS-CoV-2 and its active particles with subsequent virus delivery to the liver and spleen macrophages. Thus, the erythrocytes act as elimination for SARS-CoV-2 in COVID-19. Moreover, the erythrocyte stored, release sphingosine-1 phosphate (S1P) improves endothelial and regulates lymphocyte functions. SARS-CoV-2 ORF8 protein binds the porphyrin part of hemoglobin heme at the β1 chain, causing hemolysis and dysfunctional hemoglobin to reduce oxygen-carrying capacity. In conclusion, SARS-CoV-2 infection and associated pro-inflammatory disorders lead to abnormal erythrocrine function with subsequent inflammatory complications and endothelial dysfunction due to deficiency of protective released molecules (NO, G1P, and ATP) from functional erythrocytes. In vitro, preclinical, and clinical studies are mandatory in this regard.

show abstract

The crucial role of prolactin-lactogenic hormone in Covid-19

Cited by 36 publications

References 100 publications

Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

Gene Networks of Hyperglycemia, Diabetic Complications, and Human Proteins Targeted by SARS-CoV-2: What Is the Molecular Basis for Comorbidity?

Relationship Between Genistein Intake and Body Mass Index (BMI) with Serum Prolactin Levels in Breastfeeding Women in the Area of Benowo and Kenjeran Public Health Centers

COVID-19 and erythrocrine function: The roller coaster and danger

Contact Info

Product

Resources

About