The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine

Hoogsteen, Karst

doi:10.1107/s0365110x63002437

Cited by 470 publications

(281 citation statements)

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“…An example where optional fields are useful is in comparison of Watson-Crick, Hoogsteen and reverse Hoogsteen hydrogen-bond patterns (Hoogsteen, 1959(Hoogsteen, , 1963Saenger, 1984). The graph set of the Watson-Crick pattern is characteristic, but the graph sets of the other two types are identical to one another even though their hydrogen-bond patterns are not.…”

Section: Troubleshootingmentioning

confidence: 99%

Graph-set analysis of hydrogen-bond patterns in organic crystals

Etter¹,

MacDonald²,

Bernstein³

1990

Acta Crystallogr B Struct Sci

2,597

1,839

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The pressure-induced structural transformation of CHD involves, apart from other effects, the interchange of donor and acceptor sites by the enolic H atoms in the hydrogen bonds. The structure, despite its close similarities with antiferroelectric crystals, is ordered in the high-pressure phase, also retaining its low-pressure symmetry. It is possible that the crystals have a domain structure in both low-and highpressure phases. The proposed mechanism of the transformation strongly suggests an important role of electrostatic interactions in the transformation and in the jump of the enolic H atom to its other site in the OH---O bond. This mechanism also affords an explanation of the phase transition observed in CPD and of the exceptional stability of MCPD at high pressures; however, several points still need to be confirmed and further studies are being carried out on the CHD crystals.The author is grateful to Professor Z. Katuski for encouragement, to Dr R. J. Nelmes for his invitation to use the high-pressure and X-ray facilities of the Physics Department, University of Edinburgh, to Professor M. C. Etter of the Department of Chemistry, University of Minnesota, for stimulating discussions and providing the 1,3-cyclohexanedione samples crystallized from 2-pentanone, and to Dr J. Koput (Adam Mickiewicz University) for his expertise in the MNDO calculations. This study was partly supported by the British Council and by the Polish Academy of Sciences, Project CPBP, 01.12.References ALLMANN, R. (1977 AbstractA method is presented based on graph theory for categorizing hydrogen-bond motifs in such a way that complex hydrogen-bond patterns can be disentangled, or decoded, systematically and consistently. * Alfred P. Sloan Foundation Fellow, 1989-1991 This method is based on viewing hydrogen-bond patterns topologically as if they were intertwined nets with molecules as the nodes and hydrogen bonds as the lines. Surprisingly, very few parameters are needed to define the hydrogen-bond motifs comprising these networks. The methods for making these assignments, and examples of their chemical utility are given.

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Section: Troubleshootingmentioning

confidence: 99%

Graph-set analysis of hydrogen-bond patterns in organic crystals

Etter¹,

MacDonald²,

Bernstein³

1990

Acta Crystallogr B Struct Sci

2,597

1,839

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“…Therefore, such bivalent NPs will have to carry two different functional biomolecules at their surface, covalently bound via thiol linkers. To accomplish DNA hybridisation in non-denatured, chromatin triplex formation as described by Hoogsteen (1963) is necessary. As triplex hybridisation with DNA probes is rather weak, new DNA derivates, such as locked nucleic acids (LNA) and peptide nucleic acids, were developed to form more stable bindings (Johnson & Fresco 1999a, Buchini & Leumann 2003, Seidman & Glazer 2003.…”

Section: Anchoring the Nanogold Label: Principle Of Signal Recognitionmentioning

confidence: 99%

Sex selection of sperm in farm animals: status report and developmental prospects

Rath¹,

Barcikowski²,

Graaf³

et al. 2013

Reproduction

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Pre-selection of spermatozoa based on the relative DNA difference between X-and Y-chromosome bearing populations by flow cytometry is an established method that has been introduced into commercial cattle production. Although several important improvements have increased the sort efficiency, the fertilising ability of sexed spermatozoa based on offspring per insemination is still behind farmers' expectations. The main stress factors, especially on mitochondria, that reduce the lifespan of spermatozoa are described, and new technical as well as biological solutions to maintain the natural sperm integrity and to increase the sorting efficiency are discussed. Among these methods are the identification of Y-chromosome bearing spermatozoa by bi-functionalised gold nanoparticles and triplex hybridisation in vivo as well as new laser-controlled deflection system that replaces the deflection of spermatozoa in the electrostatic field. Additionally, as well as a new nonsurgical transfer system of spermatozoa into the oviduct of cows has been developed and allows a significant reduction of spermatozoa per transfer. Altogether, the improvements made in the recent years will allow a broader use of sex-sorted spermatozoa even in those species that require more cells than cows and sheep.Reproduction (2013) 145 R15-R30

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“…Об'єктами дослідження слугували вотсон-криківська пара основ ДНК G⋅C WC [1], льовдінівська пара основ ДНК G*⋅C* L [14,15], утворена мутагенними таутомерами [16], обер-нена льовдінівська G*⋅C* rL [6], гугстинівська КОРОТКі ПОВіДОмлеННя G*⋅C* H [11] та обернена гугстинівська G*⋅C* rH [13] пари основ.…”

Section: матеріали і методиunclassified

“…В ідомо, що вотсон-криківська пара ос-нов аденін⋅тимін (А⋅Т WC) [1], що стабілізується трьома кооперативними [2] міжмолекулярними Н-зв'язками N6H…O4, N3H…N1 i C2H….O2 [3,4], які взаємно по-силюють один одного [5], може набувати ще трьох воднево-зв'язаних конфігурацій, а саме-А⋅Т rWC [6], А⋅Т H [7][8][9][10][11] i А⋅Т rH [12,13]. Усі ці чотири конфігурації пари А⋅Т є біологічно важливими.…”

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“…Так, вотсон-криківська схема спа-рювання реалізується в антипаралельних лан-цюгах подвійної правозакрученої спіралі ДНК [1], обернена вотсон-криківська пара основ (A⋅T rWC), утворена обертанням однієї основи навколо іншої на 180°, спостерігається у ДНК з паралельними ланцюгами [6]. Гугстинівська [11] пара основ (A⋅T H) виконує чимало біологічних функцій: її зафіксовано в числен-них молекулярних процесах, які відбуваються в ядрі клітини та асистують експресію генів, реплікацію, рекомбінацію та підтримання дов-жини теломер [7][8][9][10]. Обернена гугстинівська пара основ (A⋅T rH) [13] утворюється повертан-ням однієї основи на 180° відносно іншої -вона, зокрема, виявлена в комплексах ДНК з лікарськими препаратами [8], у протеїново-нуклеїнових комплексах [9,10] та у складі РНК [12].…”

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Under what conditions does G•C watson-crick DNA base pair acquire all four configurations characteristic for A•T watson-crick DNA base pair?

Brovarets’¹

2013

Ukr.Biochem.J.

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The crystal and molecular structure of a hydrogen-bonded complex between 1-methylthymine and 9-methyladenine

Cited by 470 publications

References 1 publication

Graph-set analysis of hydrogen-bond patterns in organic crystals

Graph-set analysis of hydrogen-bond patterns in organic crystals

Sex selection of sperm in farm animals: status report and developmental prospects

Under what conditions does G•C watson-crick DNA base pair acquire all four configurations characteristic for A•T watson-crick DNA base pair?

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