The current challenges for pancreas transplantation for diabetes mellitus

Watson, Chris

doi:10.1016/j.phrs.2015.01.005

Cited by 10 publications

(6 citation statements)

References 121 publications

(126 reference statements)

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“…It improved transplanted islet survival in NOD mice, especially when combined with antigen-based therapy [51], as described in another section. A major limitation of clinical islet transplantation is that the majority of islets die soon after transplantation due to a combination of factors; most notably hypoxia and an acute inflammatory response [52][53][54]. In studies with human cells, we demonstrated that GABA markedly reduced islet-cell apoptosis in culture, and stimulated insulin production [34,55].…”

Section: Studies In Humansmentioning

confidence: 90%

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

Prud’homme

Glinka

Wang

2015

Autoimmunity Reviews

107

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Section: Studies In Humansmentioning

confidence: 90%

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

Prud’homme

Glinka

Wang

2015

Autoimmunity Reviews

107

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“…Pancreas transplantation is an effective method for the treatment of end-stage DM. [11][12][13] The difficulty of pancreas transplantation is mainly due to the anatomical and physiological characteristics of the pancreas itself. The pancreatic blood supply and structure are complicated by the multiple blood vessels involved.…”

Section: Discussionmentioning

confidence: 99%

Novel surgical technique and efficacy analysis of donor pancreas preparation without vascular reconstruction in pancreas transplantation

et al. 2019

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Objective Because of the complicated blood supply and vascular structure of the pancreas, blood vessel reconstruction and reshaping are generally required during pancreas transplantation. We modified the vascular preparation procedure for the donor pancreas (i.e., no vascular reconstruction was performed) based on experiences in our department and in other domestic and international transplantation centers. Methods Twelve donor pancreas preparations without vascular reconstruction were performed. The patch (Carrel patch), celiac trunk, and superior mesenteric artery were preserved as arterial inflow channels for the donor pancreas. The common hepatic artery and the gastroduodenal artery were transected at a site 0.5 cm away from the bifurcation. The bifurcated portion was preserved for the donor liver. The stumps of the gastroduodenal artery and common hepatic artery were then ligated. The portal vein was transected in the middle of the hepatoduodenal ligament during separation of the liver and pancreas. The partial portal vein preserved with the pancreas was used as the outflow channel of the donor pancreas. Results The transplanted pancreas functioned well in the recipients, and no vascular complications were reported. Conclusion The overall efficacy of pancreas transplantation without vascular reconstruction has been improved.

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“…El riesgo de muerte después de un trasplante de islotes es extremadamente bajo. En términos de malignidad, el registro CITR destaca pacientes con tumores basocelulares de piel o carcinoma de células escamosas, con una tasa global de 2,3%, probablemente resultante de la inmunosupresión crónica 66 .…”

Section: Riesgos Asociados Al Trasplante De Islotesunclassified

Mesa 3: Presente Y Futuro De Las Terapias Biológicas Para El Tratamiento De La Diabetes Mellitus Tipo 1

Grosembacher,

Pereyra Bonnet,

Muratore

et al. 2023

Rev. Soc. Argent. Diabetes

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The current challenges for pancreas transplantation for diabetes mellitus

Cited by 10 publications

References 121 publications

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

Immunological GABAergic interactions and therapeutic applications in autoimmune diseases

Novel surgical technique and efficacy analysis of donor pancreas preparation without vascular reconstruction in pancreas transplantation

Mesa 3: Presente Y Futuro De Las Terapias Biológicas Para El Tratamiento De La Diabetes Mellitus Tipo 1

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