The Current Limitations and Advanced Analysis of Hemodynamic Study of Cerebral Aneurysms

Cho, Kwang‐Chun

doi:10.5469/neuroint.2023.00164

Cited by 4 publications

(1 citation statement)

References 40 publications

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“…CFD serves as a primary method for hemodynamic analysis, necessitating assumptions such as non-Newtonian fluid properties and rigid vessel walls. However, these assumptions significantly deviate from reality, considering the substantial variations in blood and vessel characteristics among individuals, imposing limitations on the applicability of CFD analysis [107]. In the context of turbulent fluid flow, the choice of turbulence models can impact simulation results.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Huang,

Zheng,

et al. 2023

Bioengineering

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In recent years, nanomedicines prepared using supercritical technology have garnered widespread research attention due to their inherent attributes, including structural stability, high bioavailability, and commendable safety profiles. The preparation of these nanomedicines relies upon drug solubility and mixing efficiency within supercritical fluids (SCFs). Solubility is closely intertwined with operational parameters such as temperature and pressure while mixing efficiency is influenced not only by operational conditions but also by the shape and dimensions of the nozzle. Due to the special conditions of supercriticality, these parameters are difficult to measure directly, thus presenting significant challenges for the preparation and optimization of nanomedicines. Mathematical models can, to a certain extent, prognosticate solubility, while simulation models can visualize mixing efficiency during experimental procedures, offering novel avenues for advancing supercritical nanomedicines. Consequently, within the framework of this endeavor, we embark on an extensive review encompassing the application of mathematical models, artificial intelligence (AI) methodologies, and computational fluid dynamics (CFD) techniques within the medical domain of supercritical technology. We undertake the synthesis and discourse of methodologies for calculating drug solubility in SCFs, as well as the influence of operational conditions and experimental apparatus upon the outcomes of nanomedicine preparation using supercritical technology. Through this comprehensive review, we elucidate the implementation procedures and commonly employed models of diverse methodologies, juxtaposing the merits and demerits of these models. Furthermore, we assert the dependability of employing models to compute drug solubility in SCFs and simulate the experimental processes, with the capability to serve as valuable tools for aiding and optimizing experiments, as well as providing guidance in the selection of appropriate operational conditions. This, in turn, fosters innovative avenues for the development of supercritical pharmaceuticals.

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Section: Challenges and Opportunitiesmentioning

confidence: 99%

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Huang,

Zheng,

et al. 2023

Bioengineering

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Influence of circle of Willis modeling on hemodynamic parameters in anterior communicating artery aneurysms and recommendations for model selection

Yang,

Cho,

Hong

et al. 2024

Sci Rep

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Computational fluid dynamics (CFD) has been utilized to calculate hemodynamic parameters in anterior communicating artery aneurysm (AComA), which is located at a junction between left and right A1 and A2 segments. However, complete or half circle of Willis (CoW) models are used indiscriminately. This study aims to suggest recommendations for determining suitable CoW model. Five patient-specific CoW models with AComA were used, and each model was divided into complete, left-half, and right-half models. After validating the CFD using a flow experiment, the hemodynamic parameters and flow patterns in five AComAs were compared. In four out of five cases, inflow from one A1 side had a dominant influence on the AComA, while both left and right A1 sides affected the AComA in the remaining case. Also, the average difference in time-averaged wall shear stress between the complete and half models for four cases was 4.6%, but it was 62% in the other case. The differences in the vascular resistances of left and right A1 and A2 segments greatly influenced the flow patterns in the AComA. These results may help to enhance clinicians’ understanding of blood flow in the brain, leading to improvements in diagnosis and treatment of cerebral aneurysms.

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3D engineering of diseased blood vessels for integrative in vitro–in silico mechanobiology study

Park,

Lee,

Choi

et al. 2024

Biofabrication

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Vascular diseases are complex conditions orchestrated by multiple factors, including cellular components, biochemical stimuli, and mechanical forces. Despite the advancement of numerous therapeutic approaches, the global mortality associated with the diseases continues to escalate owing to a lack of understanding of the underlying pathologies. Tissue engineering and computational strategies have been recently developed to investigate diseased blood vessels from multifactorial perspective, enabling more accurate prediction of disease progression and opening new avenues for preclinical advances. This review focuses on in vitro and in silico blood vessel models to elucidate the pathomechanisms of vascular diseases. Following a discussion of biofabrication and computational modeling strategies, the recent research that utilizes the models of various blood vessel diseases, such as atherosclerosis, aneurysms, varicose veins, and thrombosis, are introduced. Finally, current breakthroughs, existing challenges, and outlooks in the field are described.

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The Current Limitations and Advanced Analysis of Hemodynamic Study of Cerebral Aneurysms

Cited by 4 publications

References 40 publications

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Simulation and Optimization: A New Direction in Supercritical Technology Based Nanomedicine

Influence of circle of Willis modeling on hemodynamic parameters in anterior communicating artery aneurysms and recommendations for model selection

3D engineering of diseased blood vessels for integrative in vitro–in silico mechanobiology study

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