The Current State of Knowledge on Baggio–Yoshinari Syndrome (Brazilian Lyme Disease-like Illness): Chronological Presentation of Historical and Scientific Events Observed over the Last 30 Years

Yoshinari, Natalino Hajime; Bonoldi, Virgínia Lúcia Nazário; Bonin, Serena; Falkingham, Erica; Trevisan, Giusto

doi:10.3390/pathogens11080889

Cited by 12 publications

(11 citation statements)

References 68 publications

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“…For South America, several Lyme disease group genospecies have previously been documented in both wild mammals and ticks [8,38,42,[78][79][80]. In countries such as Brazil, the Baggio-Yoshinari syndrome has occurred, which is clinically similar to Lyme disease [81]; however, the causative agent could not be confirmed to be B. burgdorferi s.s. [82].…”

Section: Discussionmentioning

confidence: 99%

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

et al. 2022

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The genus Borrelia encompasses spirochetal species that are part of three well-defined groups. Two of these groups contain pathogens that affect humans: the group causing Lyme disease (LDG) and the relapsing fever group (RFG). Lyme disease is caused by Borrelia burgdorferi s.l., which is distributed in the Northern Hemisphere, and relapsing fevers are caused by Borrelia spp., which are found in temperate and tropical countries and are an emerging but neglected pathogens. In some departments of Colombia, there are records of the presence of Borrelia sp. in humans and bats. However, little is known about the impact and circulation of Borrelia spp. in the country, especially in wildlife, which can act as a reservoir and/or amplifying host. In this context, the objective of our research was to detect and identify the Borrelia species present in wild mammals in the departments of Caldas and Risaralda in Colombia. For morphological detection, blood smears and organ imprints were performed, and molecular identification was carried out through a nested PCR directed on the flagellin B (flaB) gene. A total of 105 mammals belonging to three orders (Chiroptera, Didelphimorphia and Rodentia) were analyzed, of which 15.24% (n = 16) were positive for Borrelia. Molecularly, the presence of Borrelia burgdorferi s.s. in lung tissues of Thomasomys aureus and blood of Mus musculus (Rodentia) was detected, with 99.64 and 100% identity, respectively. Borrelia sp. genospecies from a clade branch of a bat-associated LDG sister group were identified in seven individuals of bat species, such as Artibeus lituratus, Carollia brevicauda, Sturnira erythromos, and Glossophaga soricina. Furthermore, two Borrelia genospecies from the RFG in seven individuals of bats (A. lituratus, Artibeus jamaicensis, Platyrrhinus helleri, Mesophylla macconnelli, Rhynchonycteris naso) and rodents (Coendou rufescens, Microryzomys altissimus) were documented. Additionally, the presence of a spirochete was detected by microscopy in the liver of a Sturnira erythromos bat specimen. These results contain the first molecular evidence of the presence of B. burgdorferi s.s. in South America, which merits the need for comprehensive studies involving arthropods and vertebrates (including humans) in other departments of Colombia, as well as neighboring countries, to understand the current status of the circulation of Borrelia spp. in South America.

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Section: Discussionmentioning

confidence: 99%

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

et al. 2022

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“…In Mexico, Lyme disease has been reported due to the recent detection of B. burgdorferi (ss) DNA in ticks. Additionally, specific serological evidence has been previously confirmed in patients with clinical and epidemiological suspicions of the disease [ 12 , 13 , 14 ]. B. ibitipoquensis has recently been isolated from I. paranaensis [ 14 ].…”

Section: What Tick Species Are Likely To Transmit Lyme Disease In Arg...mentioning

confidence: 99%

Lyme Disease: A Review with Emphasis on Latin America

Lucca,

Nuñez,

Pucheta

et al. 2024

Microorganisms

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The spirochete Borrelia burgdorferi sensu lato (Lyme Group) is the causative agent of Lyme disease, transmitted to humans through tick bites carrying the bacteria. Common symptoms include fever, headache, fatigue, and the characteristic erythema migrans skin rash. If left untreated, the infection can affect joints, the cardiac system, and the nervous system. Diagnosis relies on symptoms, clinical signs (such as the rash), and potential exposure to infected ticks, with laboratory tests proving valuable when appropriately employed with validated methods. Most cases of Lyme disease respond effectively to a few weeks of antibiotic treatment. In Latin America, knowledge of Lyme disease is limited and often confounded, underscoring the significance of this review in aiding medical professionals in recognizing the disease. This study delves explicitly into Lyme disease in Argentina, neighboring countries, and other Latin American nations.

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“…A controversial tick-borne disease in Brazil is Lyme borreliosis. Lyme-like disease has been diagnosed since 1992 [95,96]. The disease is routinely diagnosed based on clinical and serological data and records of suspected cases included in the Brazilian Ministry of Health database [96].…”

Section: Brazilmentioning

confidence: 99%

Perception of Ticks and Tick-Borne Diseases Worldwide

de la Fuente,

Estrada-Peña,

Rafael

et al. 2023

Pathogens

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In this comprehensive review study, we addressed the challenge posed by ticks and tick-borne diseases (TBDs) with growing incidence affecting human and animal health worldwide. Data and perspectives were collected from different countries and regions worldwide, including America, Europe, Africa, Asia, and Oceania. The results updated the current situation with ticks and TBD and how it is perceived by society with information bias and gaps. The study reinforces the importance of multidisciplinary and international collaborations to advance in the surveillance, communication and proposed future directions to address these challenges.

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The Current State of Knowledge on Baggio–Yoshinari Syndrome (Brazilian Lyme Disease-like Illness): Chronological Presentation of Historical and Scientific Events Observed over the Last 30 Years

Cited by 12 publications

References 68 publications

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

Is Borrelia burgdorferi Sensu Stricto in South America? First Molecular Evidence of Its Presence in Colombia

Lyme Disease: A Review with Emphasis on Latin America

Perception of Ticks and Tick-Borne Diseases Worldwide

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